SLN.L Regulatory News (SLN)

(a) Identity of the person whose positions/dealings are being disclosed:

Smith & Williamson Investment Management Limited

(b) Owner or controller of interests and short positions disclosed, if different from 1(a):

The naming of nominee or vehicle companies is insufficient

(c) Name of offeror/offeree in relation to whose relevant securities this form relates:

Use a separate form for each offeror/offeree

Silence Therapeutics plc

(d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of offeror/offeree:

n/a

(e) Date position held/dealing undertaken:

7th September 2010

(f) Has the discloser previously disclosed, or are they today disclosing, under the Code in respect of any other party to this offer?

n/a

Class of relevant security:

1p Ordinary

Interests

Short positions

Number

%

Number

%

(1) Relevant securities owned and/or controlled:

3,562,054

1.27%

(2) Derivatives (other than options):

(3) Options and agreements to purchase/sell:

TOTAL:

3,562,054

1.27%

Class of relevant security in relation to which subscription right exists:

n/a

Details, including nature of the rights concerned and relevant percentages:

n/a

Class of relevant security

Purchase/sale

Number of securities

Price per unit

Ordinary

Purchase

30,000

12.965p

Class of relevant security

Product description

e.g. CFD

Nature of dealing

e.g. opening/closing a long/short position, increasing/reducing a long/short position

Number of reference securities

Price per unit

n/a

Class of relevant security

Product description e.g. call option

Writing, purchasing, selling, varying etc.

Number of securities to which option relates

Exercise price per unit

Type

e.g. American, European etc.

Expiry date

Option money paid/ received per unit

n/a

Class of relevant security

Product description

e.g. call option

Number of securities

Exercise price per unit

n/a

Class of relevant security

Nature of dealing

e.g. subscription, conversion

Details

Price per unit (if applicable)

n/a

Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:

If there are no such agreements, arrangements or understandings, state "none"

None

Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:

(i) the voting rights of any relevant securities under any option; or

(ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:

If there are no such agreements, arrangements or understandings, state "none"

None

Is a Supplemental Form 8 (Open Positions) attached?

No

8th September 2010

Stephen Hamilton-Jones

Compliance Manager

Smith & Williamson Investment Management Limited.

020 7131 4734