Synairgen Regulatory News (SNG)

NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible)i

1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attachedii:

Synairgen plc

1b. Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)

Non-UK issuer

2. Reason for the notification (please mark the appropriate box or boxes with an "X")

An acquisition or disposal of voting rights

X

An acquisition or disposal of financial instruments

An event changing the breakdown of voting rights

Other (please specify)iii:

3. Details of person subject to the notification obligationiv

Name

Bong Koh and Nimish Shah (as the voting members of VHCP Management II, LLC and VHCP Management III, LLC)

City and country of registered office (if applicable)

New York, NY, U.S.A.

4. Full name of shareholder(s) (if different from 3.)v

Name

See section 11 below

City and country of registered office (if applicable)

New York, NY, U.S.A.

5. Date on which the threshold was crossed or reachedvi:

23 October 2020

6. Date on which issuer notified (DD/MM/YYYY):

27 October 2020

7. Total positions of person(s) subject to the notification obligation

% of voting rights attached to shares (total of 8. A)

% of voting rights through financial instruments(total of 8.B 1 + 8.B 2)

Total of both in % (8.A + 8.B)

Total number of voting rights of issuervii

Resulting situation on the date on which threshold was crossed or reached

3.91%

3.91%

165,104,676

Position of previous notification (if

applicable)

4.64%

4.64%

8. Notified details of the resulting situation on the date on which the threshold was crossed or reachedviii

A: Voting rights attached to shares

Class/type ofshares

ISIN code (if possible)

Number of voting rightsix

% of voting rights

Direct

(Art 9 of Directive 2004/109/EC) (DTR5.1)

Indirect

(Art 10 of Directive 2004/109/EC) (DTR5.2.1)

Direct

(Art 9 of Directive 2004/109/EC) (DTR5.1)

Indirect

(Art 10 of Directive 2004/109/EC) (DTR5.2.1)

Ordinary Shares

ISIN: GB00B0381Z20

6,455,000

3.91%

SUBTOTAL 8. A

6,455,000

3.91%

B 1: Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC (DTR5.3.1.1 (a))

Type of financial instrument

Expirationdatex

Exercise/Conversion Periodxi

Number of voting rights that may be acquired if the instrument is

exercised/converted.

% of voting rights

SUBTOTAL 8. B 1

B 2: Financial Instruments with similar economic effect according to Art. 13(1)(b) of Directive 2004/109/EC (DTR5.3.1.1 (b))

Type of financial instrument

Expirationdatex

Exercise/Conversion Period xi

Physical or cash

settlementxii

Number of voting rights

% of voting rights

SUBTOTAL 8.B.2

9. Information in relation to the person subject to the notification obligation (please mark the

applicable box with an "X")

Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuerxiii

Full chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held starting with the ultimate controlling natural person or legal entityxiv (please add additional rows as necessary)

X

Namexv

% of voting rights if it equals or is higher than the notifiable threshold

% of voting rights through financial instruments if it equals or is higher than the notifiable threshold

Total of both if it equals or is higher than the notifiable threshold

Bong Koh and Nimish Shah (as the voting members of VHCP Management II, LLC and VHCP Management III, LLC)

3.91%

N/A

3.91%

Bong Koh and Nimish Shah (as the votingmembers of VHCP Management II, LLC)

N/A

N/A

N/A

VHCP Management II, LLC

N/A

N/A

N/A

Bong Koh and Nimish Shah (as the votingmembers of VHCP Management III, LLC)

N/A

N/A

N/A

VHCP Management III, LLC

N/A

N/A

N/A

10. In case of proxy voting, please identify:

Name of the proxy holder

The number and % of voting rights held

The date until which the voting rights will be held

11. Additional informationxvi

Bong Koh and Nimish Shah are the voting members of VHCP Management II, LLC and VHCP Management III, LLC.

VCHP Management II, LLC is the general partner of Venrock Healthcare Capital Partners II, L.P. and manager of VHCP Co-Investment Holdings II, LLC, each of which holds shares in Synairgen plc falling below the notifiable threshold.

VHCP Management III, LLC is the general partner of Venrock Healthcare Capital Partners III, L.P. and manager of VHCP Co-Investment Holdings III, LLC, each of which holds shares in Synairgen plc falling below the notifiable threshold.

All percentages are based on the notified current issued share capital of Synairgen plc of 165,104,676 ordinary shares.

Place of completion

New York, NY, U.S.A.

Date of completion

27 October 2020