Sant Uk.10te% Regulatory News (SAN)

Abbey National Treasury Services plc(incorporated in England and Wales with registered number 2338548)

and

SANTANDER UK PLC(incorporated in England and Wales with registered number 2294747)

NOTICE OF Substitution of Issuer

to the holders of:

Series 334 EUR125,000,000 Floating Rate Notes due September 2020 (ISIN: XS0543243918)

Series 372 GBP1,364,000 Equity Index Redemption Notes due February 2019

(ISIN: XS0582309018)

Series 373 EUR1,523,000 Equity Index Linked Redemption Notes due February 2019 (ISIN: XS0582298732)

Series 380 EUR1,000,000 Floating Rate Notes due January 2021 (ISIN: XS0585498438)

Series 381 EUR1,000,000 Fixed Rate and Inflation Linked Notes due January 2018 (ISIN: XS0585525933)

Series 400 EUR15,000,000 Step-up Fixed Rate Notes due April 2019 (ISIN: XS0599124020)

Series 414 EUR700,000 Capital-at-risk Equity Linked Automatic Early Redemption Notes due April 2018 (ISIN: XS0611410498)

Series 441 EUR1,250,000 Capital-at-risk Equity Linked Automatic Early Redemption Notes due May 2018 (ISIN: XS0621527885)

Series 526 GBP3,941,230 Inflation Linked Redemption Notes due November 2017 (ISIN: XS0670978740)

Series 535 GBP2,799,162 Inflation Linked Redemption Notes due December 2017 (ISIN: XS0683559743)

Series 542 GBP4,599,195 Inflation Linked Redemption Notes due December 2017 (ISIN: XS0697417979)

Series 560 GBP150,000 Equity Linked Redemption Notes due February 2018 (ISIN: XS0721542230)

Series 601 GBP10,263,994 Inflation Linked Redemption Notes due May 2018 (ISIN: XS0748970703)

Series 621 GBP 3,000,000 Capital-at-risk Fixed Rate and Equity Linked Redemption Notes due May 2018 (ISIN: XS0761569721)

Series 623 USD2,000,000 Inflation Linked Interest Bearing Notes due March 2022 (ISIN XS0762975257)

Series 624 GBP4,615,540 Inflation Index Linked Redemption Notes due June 2018 (ISIN: XS0764902101)

Series 640 GB2,206,590 Inflation Linked Redemption Notes due July 2018 (ISIN: XS0775860918)

Series 656 USD12,413,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due July 2018 (ISIN: XS0778435825)

Series 664 GBP2,072,393 Inflation Linked Redemption Notes due August 2018 (ISIN: XS0783021271)

Series 682 GBP1,895,991 Inflation Index Linked Redemption due September 2018 (ISIN: XS0794793736)

Series 697 USD8,332,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due October 2018 (ISIN: XS0810173285)

Series 705 GBP20,083,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due October 2018 (ISIN: XS0815510499)

Series 713 USD9,650,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due December 2018 (ISIN: XS0823306583)

Series 727 USD9,650,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due December 2018 (ISIN: XS0838537941)

Series 732 USD2,500,000 Capital-at-risk Equity Index and Fund Linked Automatic Early Redemption Notes due November 2017 (ISIN: XS0841358012)

Series 733 EUR500,000 Capital-at-risk Equity Index and Fund Linked Automatic Early Redemption Notes due November 2017 (ISIN: XS0842068651)

Series 734 GBP1,600,000 Capital-at-risk Equity Index and Fund Linked Automatic Early Redemption Notes due November 2017 (ISIN: XS0842068909)

Series 739 USD5,300,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due February 2019 (ISIN: XS0846845542)

Series 748 GBP5,719,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due February 2018 (ISIN: XS0851331446)

Series 751 USD750,000 Capital-at-risk Equity Index Linked Redemption Notes due November 2017 (ISIN: XS0857432107)

Series 753 GBP2,345,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due February 2019 (ISIN: XS0858831190)

Series 768 USD7,945,000 Capital-at-risk Variable Interest and Equity Linked Redemption Notes due March 2019 (ISIN: XS0868503201)

Series 770 GBP4,763,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due April, 2019 (ISIN: XS0878439396)

Series 784 USD2,184,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due May 2019 (ISIN: XS0897775424)

Series 788 GBP4,480,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due May 2019 (ISIN: XS0904686184)

Series 790 USD100,000,000 Callable Zero Coupon Notes due March, 2043 (ISIN: XS0907246812)

Series 791 USD2,000,000 Capital-at-risk Variable Interest Equity Index Linked Notes due March, 2019 (ISIN: XS0908239220)

Series 797 USD800,000 Capital-at-risk- Fixed Rate Credit Linked Notes due April 2018 (ISIN: XS0914265870)

Series 799 GBP1,620,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due June 2019 (ISIN: XS0916373672)

Series 825 GBP1,479,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due August 2019 (ISIN: XS0943398478)

Series 847 GBP7,500,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due September 2019 (ISIN: XS0952585908)

Series 867 USD5,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due November 2019 (ISIN: XS0968460021)

Series 895 GBP10,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due November 2020 (ISIN: XS0991297432)

Series 898 USD994,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due March 2019 (ISIN: XS0989397848)

Series 924 USD11,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due May 2020 (ISIN: XS1018101516)

Series 899 EUR1,500,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due November 2019 (ISIN: XS0995135869)

Series 947 USD3,000,000 Equity Index Linked Redemption Notes due February 2021 (ISIN: XS1035604112)

Series 959 EUR4,500,000 Capital-at-risk Fixed Rate and Equity Index Linked Redemption Notes due June 2022 (ISIN: XS1052629067)

Series 960 USD10,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due July 2020 (ISIN: XS1054709081)

Series 965 USD1,000,000 Variable Interest and Equity Index Linked Redemption Notes due April 2019 (ISIN: XS1059396041)

Series 969 USD1,603,000 Variable Interest and Equity Index Linked Redemption Notes due May 2019 (ISIN: XS1064049841)

Series 974 USD50,000,000 Callable Zero Coupon Notes due May 2044 (ISIN: XS1067933363)

Series 985 USD3,973,000 Variable Interest and Equity Index Linked Redemption Notes due June 2018 (ISIN: XS1073218452)

Series 987 USD10,000,000 Equity Index Linked Redemption Notes due September 2020 (ISIN: XS1075916566)

Series 990 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due September 2020 (ISIN: XS1075916996)

Series 991 EUR3,000,000 Capital-at-risk Equity Index Redemption Notes due September 2022 (ISIN: XS1076436309)

Series 995 USD6,850,000 Capital-at-risk Equity Index Redemption Notes due July 2018 (ISIN: XS1082235026)

Series 996 EUR1,800,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due July 2019 (ISIN: XS1082827897)

Series 1002 USD16,326,000 Capital-at-risk Equity Index Redemption Notes due July 2018 (ISIN: XS1088824765)

Series 1016 EUR3,600,000 Capital-at-risk Equity Index Redemption Notes due November 2022 (ISIN: XS1098222133)

Series 1018 USD3,838,000 Capital-at-risk Equity Index Redemption Notes due August 2018 (ISIN: XS1103717218)

Series 1020 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due December 2020 (ISIN: XS1106950394)

Series 1023 USD11,246,000 Capital-at-risk Equity Index Redemption Notes due October 2018 (ISIN: XS1109752441)

Series 1026 EUR20,000,000 Callable Fixed Rate Notes due 2029 (ISIN: XS1112171738)

Series 1027 USD9,582,000 Capital-at-risk Equity Index Redemption Notes due October 2018 (ISIN: XS1113013368)

Series 1041 EUR14,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due December 2021 (ISIN: XS1120551186)

Series 1044 EUR2,00,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due October 2019 (ISIN: XS1124895688)

Series 1052 USD10,811,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due November 2019 (ISIN: XS1131231844)

Series 1053 EUR5,100,000 Capital-at-risk Equity Index Redemption Notes due December 2022 (ISIN: XS1132054237)

Series 1055 Capital-at-risk Fixed Rate and Equity Index Linked Redemption Notes due March 2021 (ISIN: XS1134224598)

Series 1058 6,750 European Style Call Warrants Linked to an Equity Index (ISIN: GB00BSMSR959)

Series 1067 EUR18,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due March 2022 (ISIN: XS1161869935)

Series 1077 GBP10,000,000 Capital-at-risk Equity Index Linked Automatic Early Redemption Notes due May 2021 (ISIN: XS1201897359)

Series 1086 EUR4,000,000 Capital-at-risk Equity Index Linked Redemption Notes due June 2023 (ISIN: XS1213102442)

Series 1087 USD7,000,000 Capital-at-risk Fixed Rate and Equity Index Linked Automatic Early Redemption Notes due July 2021 (ISIN: XS1216621836)

Series 1088 EUR2,000,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due May 2018 (ISIN: XS1232300605)

Series 1090 EUR3,000,000 Capital-at-risk Equity Index Linked Automatic Early Redemption Notes due October 2023 (ISIN: XS1255376185)

Series 1095 GBP4,000,000 Capital-at-risk Autocallable Notes Linked to Eurostoxx 50 due 2021 (ISIN: XS1308020871)

Series 1096 USD270,000,000 Callable Zero Coupon Notes due March 2046 (ISIN: XS1377475709)

Series 1098 GBP7,815,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due July 2022 (ISIN: XS1410337197)

Series 1099 USD150,000,000 Callable Zero Coupon Notes due June 2046 (ISIN: XS1421915478)

Series 1104 EUR5,000,000 Capital-at-Risk Fixed Interest and EURCMS Linked Redemption Notes due March 2018 (ISIN: XS1574113061)

Series 1105 USD 7,236,000 Capital-at-risk Variable Interest and Equity Index Linked Redemption Notes due May 2023 (ISIN: XS1575052110)

Series 1106 GBP8,000,000 Capital-at-risk Equity Index Linked Redemption Notes due March 2023 (ISIN: XS1576028705)

Series 1109 EUR3,000,000 Capital-at-Risk Fixed Interest and EURCMS Linked Redemption Notes due April 2018 (ISIN: XS1593538009)

Series 1110 GBP5,000,000 Capital-at-risk Equity Index Linked Automatic Early Redemption Notes due April 2023 (ISIN: XS1595815512)

Series 1114 GBP5,000,000 Capital-at-risk Equity Index Linked Automatic Early Redemption Notes due June 2023 (ISIN: XS1637612208)(together, the "Securities")

each issued by Abbey National Treasury Services plc under itsGlobal Structured Solutions Programme, formerly the Notes, Certificates and Warrants Programme, formerly the Structured Note Programmeunconditionally and irrevocably guaranteed by Santander UK plc

NOTICE IS HEREBY GIVEN that, with effect on and from 1 November 2017 (the "Effective Date") Santander UK plc will be substituted in place of Abbey National Treasury Services plc as principal obligor under the Securities. This substitution will be effected pursuant to a deed of substitution, novation and amendment dated 16 October 2017 entered into between, inter alios, Abbey National Treasury Services plc as original issuer, Santander UK plc as new issuer, and Citibank N.A. as principal paying agent (the "Deed of Substitution, Novation and Amendment").

On and from the Effective Date, the Securities will be the sole liability of Santander UK plc and will not be guaranteed by any other entity in the Santander UK group.

Copies of the Deed of Substitution, Novation and Amendment are available for inspection from the principal paying agent whose address is:

Citibank N.A.Citigroup Centre

Canada Square

Canary Wharf

London

E14 5LBUnited Kingdom

For further information regarding the matters set out in this notice, please contact:

Structured Notes DeskSantander UK plc2 Triton SquareRegent's PlaceLondon NW1 3AN

Tel: +44 (0)20 7756 7000

Email: structurednotesafm@santander.co.uk 

This notice does not constitute or form part of an offer to sell or the solicitation of an offer to subscribe for or otherwise acquire any securities.