Stefan Bernstein explains how the EU/Greenland critical raw materials partnership benefits GreenRoc. Watch the full video here.

Less Ads, More Data, More Tools Register for FREE

Pin to quick picksImmupharma Regulatory News (IMM)

Share Price Information for Immupharma (IMM)

London Stock Exchange
Share Price is delayed by 15 minutes
Get Live Data
Share Price: 2.125
Bid: 2.05
Ask: 2.20
Change: 0.00 (0.00%)
Spread: 0.15 (7.317%)
Open: 0.00
High: 0.00
Low: 0.00
Prev. Close: 2.125
IMM Live PriceLast checked at -

Watchlists are a member only feature

Login to your account

Alerts are a premium feature

Login to your account

Update on Cancer Compound IPP-204106 'Nucant'

16 Nov 2016 07:00

RNS Number : 2696P
Immupharma PLC
16 November 2016
 

RNS REACH : FOR IMMEDIATE RELEASE 16 NOVEMBER 2016

IMMUPHARMA PLC

 

Update on Cancer Compound IPP-204106 'Nucant'

 

Mechanism of Action Published in Prestigious Medical Journal 'Cancer Research'

 

ImmuPharma plc (LSE:IMM) ("ImmuPharma" or the "Company" or the "Group"), the specialist discovery and development pharmaceutical company, is pleased to announce that Cancer Research, the prestigious medical journal of the American Association for Cancer Research ("AACR"), has published a fundamental scientific paper disclosing the mechanism of action of the Company's cancer compound IPP-204106.

 

The IPP-204106 programme, which is a potential treatment for various cancers, involves the development of synthetic peptides, Nucants, which target surface nucleolin with very high affinity and selectivity.

 

The publication was entitled "Nucleolin targeting impairs the progression of pancreatic cancer and promotes the normalization of tumour vasculature" and was authored by a number of researchers working within ImmuPharma on the Company's Cancer programme.

The key findings of the study for this compound (referred to in the paper as N6L) were:

 

· Nucleolin inhibition is a new anti-cancer therapeutic strategy that has been shown to dually normalise tumour vasculature and reduce its volume

· As a result, it has the potential to improve dramatically the delivery and efficacy of existing chemotherapeutic drugs, and in particular, for difficult-to-treat tumours such as Pancreatic cancer

 

Dr. Robert Zimmer, MD, PhD, ImmuPharma's President and head of R&D explains: "The publication of the mechanism of action of the Nucants in Cancer Research is a validation of this novel concept in the treatment of cancer we have been developing in partnership with our collaboration partner, CNRS. It relies on the modulating effect of the Nucants on angiogenesis, the mechanism which controls the formation of micro vessels. Generally, the tumour generated micro vessels are of poor quality and offer a poor supply of blood and oxygen to the tumour. As a consequence, it makes the tumour much more resistant to cytotoxic drugs. By modulating the tumour micro vessels Nucants ameliorate the blood flow, allow a better oxygen supply and increase the intra-tumoural cytotoxic drug concentration. About threefold increase of cytotoxic drug concentration and threefold decrease in tumour size have been observed in preclinical studies. The intended treatment scheme is to pre-treat the patient with Nucant and then deliver the standard dose of cytotoxic drug, Gemcitabin for example in pancreatic cancer.

 

This is the second time that we have been acknowledged by the ACCR. The first in 2011 when our Cancer compound was chosen to be on the cover of the journal disclosing the specific binding to nucleolin and therefore to tumour cells by the Nucants. It is a pleasing validation of years of research by our scientific team and collaborators and gives us further confidence in the long term potential of our Cancer programme, this compound and its unique mechanism of action".

 

 

The publication can be seen at http://cancerres.aacrjournals.org/content/early/2016/10/15/0008-5472.CAN-16-0300 and the website of Cancer Research is http://cancerres.aacrjournals.org/

 

The 2011 publication can be seen at: http://cancerres.aacrjournals.org/content/71/9/3296

 

The full 'Abstract' is detailed below:

"Pancreatic cancer is a highly aggressive tumour, mostly resistant to the standard treatments. Nucleolin (NCL) is overexpressed in cancers and its inhibition impairs tumour growth. Herein we showed that NCL was overexpressed in human specimens of pancreatic ductal adenocarcinoma (PDAC) and that the overall survival significantly increased in patients with low levels of NCL. The NCL antagonist N6L strongly impaired the growth of primary tumours and liver metastasis in an orthotopic mouse model of PDAC (mPDAC). Similar anti-tumour effect of N6L has been observed in a highly angiogenic mouse model of pancreatic neuroendocrine tumour RIP-Tag2. N6L significantly inhibited both human and mouse pancreatic cell proliferation and invasion. Notably, the analysis of tumour vasculature revealed a strong increase of pericyte coverage and vessel perfusion both in mPDAC and RIP-Tag2 tumours, in parallel to an inhibition of tumour hypoxia. NCL inhibition directly affected endothelial cell (EC) activation and changed a pro-angiogenic signature. Among the vascular activators, NCL inhibition significantly decreased Ang-2 secretion and expression in ECs, in the tumour and in the plasma of mPDAC mice. As a consequence of the observed N6L-induced tumour vessel normalization, pre-treatment with N6L efficiently improved chemotherapeutic drug delivery and increased the anti-tumour properties of gemcitabine in PDAC mice. In conclusion, NCL inhibition is a new anti-pancreatic cancer therapeutic strategy that dually blocks tumour progression and normalizes tumour vasculature improving the delivery and efficacy of chemotherapeutic drugs. Moreover, we unveiled Ang-2 as a potential target and suitable response biomarker for N6L treatment in pancreatic cancer".

-Ends-

For further information please contact:

ImmuPharma plc (www.immupharma.org)

+ 44 (0) 20 7152 4080

Tim McCarthy, Chairman

Lisa Baderoon, Head of Investor Relations

Twitter: @immupharma

 

+ 44 (0) 7721 413496

 

 

Panmure, Gordon & Co., (NOMAD & Broker)

+44 (0) 20 7886 2500

Freddy Crossley, Duncan Monteith, Corporate Finance

Charles Leigh-Pemberton, Corporate Broking

 

Northland Capital Partners Limited (Joint Broker)

Patrick Claridge, David Hignell, Corporate Finance

Rob Rees, John Howes, Corporate Broking

 

 

 

+44 (0)20 3861 6625

 

This information is provided by RNS
The company news service from the London Stock Exchange
 
END
 
 
NRAEAXFSFLNKFFF
Date   Source Headline
25th Mar 20247:25 amRNSIncanthera provides Comm'l Update/Revenue F'casts
19th Mar 20247:00 amRNSGrant of Share Options
14th Mar 20247:00 amRNSIMMUPHARMA AT BIO-EUROPE SPRING 2024
6th Mar 20247:00 amRNSFinancial, Business and Portfolio Develop't Update
28th Dec 20231:35 pmRNSHolding(s) in Company
19th Dec 20232:50 pmRNSHolding(s) in Company
19th Dec 20237:00 amRNSSimbec-Orion appointed as CRO
18th Dec 20237:15 amRNSIncanthera - Comm'l Skincare Deal/£1M Fundraise
13th Sep 20233:47 pmRNSHolding(s) in Company
7th Sep 20237:00 amRNSResult of Retail Offer and Director Shareholding
31st Aug 20237:02 amRNSWRAP Retail Offer for up to £0.5m
31st Aug 20237:01 amRNSSubscription to raise £1.35m; Sharing Agr, RPT
31st Aug 20237:00 amRNSInterim results
21st Aug 20237:00 amRNSExtension of warrants in Incanthera plc
11th Aug 202312:04 pmRNSDirectorate Change
30th Jun 20231:12 pmRNSResult of AGM
19th Jun 20237:00 amRNSLupuzor Update
6th Jun 20237:00 amRNSIMM RNS Posting of RA and Notice of AGM 30 June 23
18th May 20237:00 amRNSPositive Pre-IND meeting with FDA
11th May 20237:00 amRNSFinal Results
10th May 20231:56 pmRNSHolding(s) in Company
19th Apr 20237:00 amRNSLupozor Update - FDA confirms Type-C meeting date
12th Apr 20237:00 amRNSCIDP P140 Clinical Program Update
27th Mar 20237:00 amRNSLupuzor™ Update
9th Mar 20234:35 pmRNSPrice Monitoring Extension
6th Mar 20237:00 amRNSCollaboration with Orano on ImmuPharma Peptide
6th Feb 20237:00 amRNSLupuzor™ Update
27th Jan 20234:25 pmRNSTR-1: Notification of major holdings
4th Jan 20235:26 pmRNSTR-1: Notification of major holdings
4th Jan 20234:40 pmRNSSecond Price Monitoring Extn
4th Jan 20234:35 pmRNSPrice Monitoring Extension
3rd Jan 20234:58 pmRNSTR-1: Notification of major holdings
22nd Dec 20227:55 amRNSGrant of Options
22nd Dec 20227:00 amRNSEnd of Year Update
22nd Nov 20223:15 pmRNSHolding(s) in Company
14th Nov 20224:40 pmRNSSecond Price Monitoring Extn
14th Nov 20224:35 pmRNSPrice Monitoring Extension
11th Nov 20227:31 amRNSLupuzor Update
11th Oct 20224:40 pmRNSSecond Price Monitoring Extn
11th Oct 20224:35 pmRNSPrice Monitoring Extension
7th Oct 20224:44 pmRNSCompany Secretary Change
6th Oct 20225:17 pmRNSHolding(s) in Company
30th Sep 20227:30 amRNSLupuzor Update
30th Sep 20227:00 amRNSInterim Results or the 6mths Ended 30 June 2022
29th Sep 20224:40 pmRNSSecond Price Monitoring Extn
29th Sep 20224:37 pmRNSPrice Monitoring Extension
14th Sep 202210:04 amRNSWritten Response received from the FDA
7th Sep 20228:25 amRNSExercise of Options
31st Aug 20227:00 amRNSFDA response for Type C Meeting - update
30th Aug 202211:29 amRNSExercise of Options

Due to London Stock Exchange licensing terms, we stipulate that you must be a private investor. We apologise for the inconvenience.

To access our Live RNS you must confirm you are a private investor by using the button below.

Login to your account

Don't have an account? Click here to register.

Quickpicks are a member only feature

Login to your account

Don't have an account? Click here to register.