AVO.L Regulatory News (AVO)

ADVANCED ONCOTHERAPY PLC

("Advanced Oncotherapy" or the "Company")

Technological update

 Successful testing supporting the superior clinical outcomes of LIGHT

Advanced Oncotherapy (AIM: AVO), the developer of next-generation proton therapy systems for cancer treatment, provides the following technological update.

The LIGHT system has been designed to electronically control the fast delivery of protons to the tumour site. This unique ability provides the opportunity to alter the exact amount of radiation that is given to every part of the tumour in a few micro-seconds. This feature is invaluable for accurate tumour targeting and side-effect minimisation, particularly in the case of moving targets. As part of its testing and regulatory plan, the Company has developed a Time-of-Flight ("TOF") measurement system which measures the speed of the beam; this allows the system to measure the energy of each proton pulse, which is a very important clinical parameter.

TOF testing of beam energy control and adjustment has proved to be successful with real-time results demonstrating remarkably good agreement with computer simulations. The accurate evaluation of the beam energy requires measurement of time differences to picosecond precision (a picosecond being the time it takes light to travel one third of a millimetre).

In the meantime, the Company continues to make significant progress with power testing of the Side Coupled Drift Tube Linac ("SCDTL") integrated with the Radiofrequency Quadrupole ("RFQ") and proton source. With much of the technological development now de-risked, the Company is on target to have a system capable of treating superficial tumours by the end of Q3 2018.

Jonathan Farr, Director of Medical Physics at Advanced Oncotherapy, said: "Proton therapy is a high precision patient treatment. In proton therapy, the beam energy determines the depth of dose deposition in the patient. Because of the protons stopping in the patient's body during treatment, we would like to know the proton beam energy at the instant it is delivered. The new Advanced Oncotherapy Time-of-Flight on-line energy measurement feature gives us the ability to do just that. I consider it to be a real advancement from previous and existing systems on the market and a key building block in offering more versatile treatments with the potential for significantly improved clinical outcomes."

For further information, please contact:

About Advanced Oncotherapy Plc www.avoplc.com

Advanced Oncotherapy is a provider of particle therapy with protons that harnesses the best in modern technology. Advanced Oncotherapy's team "ADAM", based in Geneva, focuses on the development of a proprietary proton accelerator called Linac Image Guided Hadron Technology (LIGHT). LIGHT's compact configuration delivers proton beams in a way that facilitates greater precision and electronic control which is not achievable with older technologies.

Advanced Oncotherapy will offer healthcare providers affordable systems that will enable them to treat cancer with an innovative technology as well as lower treatment related side effects.

Advanced Oncotherapy continually monitors the market for any emerging improvements in delivering proton therapy and actively seeks working relationships with providers of these innovative technologies. Through these relationships, the Company will remain the prime provider of an innovative and cost-effective system for particle therapy with protons.