AVO.L Regulatory News (AVO)

26 April 2013

ADVANCED ONCOTHERAPY Plc

("Advanced Oncotherapy" or "the Company")

Director Dealing

Advanced Oncotherapy (AIM: AVO) announces that on 25 April 2013, Tim Lebus, Non-Executive Director, purchased two tranches of ordinary shares of 1 pence each in the share capital of the Company ("Ordinary Shares"), the first tranche of 750,000 Ordinary Shares at a price of 1.56 pence per Ordinary Share. The second tranche of 213,000 Ordinary Shares was purchased at a price of 1.545 pence per Ordinary Share.

Following this purchase, Tim Lebus now holds 963,000 Ordinary Shares, representing approximately 0.37 per cent. of the issued share capital of Advanced Oncotherapy.

For further information, please visit www.advancedoncotherapy.comor contact: