RE: My personal research note - I am a firm p140 believer27 Sep 2025 15:56
Hi I qualified as a pharmacist in 2007 I then went back to university to get additional qualifications as an independent prescriber. I have then since been working in primary care in GP surgeries since seeing and prescribing for all types of patients from babies to elderly and everything in between. Luckily I have built a loyal patient base with my clinics booked months in advance with my regular patients. As a very passionate academic I have spent many years studying modern medicine and continue to do so. Alongside this I also own a substantive property portfolio, this is why I have been very fortunate to make sizable transactions across my shares portfolio. Some people find my combination hard to believe and question whether I am telling the truth. For avoidance of doubt anybody who wants to meet up I am going to the AGM meeting on 16/10 for fusion antibodies (another one of my investments) and flying to Belfast that weekend. Perhaps a F2F introduction would give my doubters more reassurance
Sorry for divulging but back to your q, which I have addressed in historical posts. Ph III failed (only just) to meet its primary endpoint and it has taken Seb et al a few years to go back to the drawing board and figure out following tweaks were needed:
) change route of administration to IV
) increase dose 10-15 fold to increase potency
) taper steroids before giving p14p to avoid interactions and reducing efficacy of p140
) perhaps the biggest discovery to date - p140 super responders. A subtype of patients that are more reciprocal to the biological effects of p140.
The latter point was not known during the first phase 3 trial but Seb et al made this phenomenal discovery in the last few years. It was this finding that was then externally validated by Jackson labs in USA. Anyone can say they have found a novel finding but to then have it examined externally that’s the biggest confirmation one can seek.
This is why I say you can no longer compare the failed trials to now as so much more is known since then and the MOA has since been identified, documented and is now being openly shared under NDAs with big Pharmas internal scientific team.
Historically we knew p140 worked but the scientists were not entirely sure how. We now know this in greater detail.
Call it luck, years of hard work or perseverance but these guys have finally elucidated the MoA