RE: A very decent review29 Dec 2025 13:26
I think you assume the market is far brighter than it is, Robert. A big and regular mistake you make.
#AVCT’s invention (ie removing the need for an antibody, thus removing the need for an antigen target, thus removing an entire stage of the ADC process, is nothing short of groundbreaking).
Look at the amount of literature around antigen targets (just HER2 is a thesis in itself I find).
Targeting FAP and removing the need for an antigen turns the entire industry on its head.
It took me a very long time to understand it, despite having followed all the soundboard and the watched the spotlights. It’s not simple (I don’t care what anyone says).
If a change can disrupt many (multi billion) business models, it’s only right diligence should take time. Why shouldn’t it? It’s critical to them.
I know what I hold too. I know the management team. I understand the technology as best as I can. I understand the various personalities involved. But I also know the market (including the analysts and the institutions) are nowhere near as tuned in as you think they are. They will follow pharma into the trade. 100%.
That why I’m looking at the structure behind Avacta as much as the process in clinic. I’m expecting more broker changes and more NOMAD changes.
On 8/12/2025 Peel Hunt was listed as NOMAD on the RNS footer ‘Preliminary Data in Faridoxorubicin Phase 1b Trial’.
On 17/12/2025 AVCT’s NOMAD was removed from the RNS footer.
Ironically, the change everyone craves (to ensure the technology is better represented) is well underway imho.
The company and board is a different beast.
As for whether the CEO could have discussed deals in the Q&A.
She’s MORE than bright enough to understand the bounds within which she can operate.
I believe Avacta is on the very cusp of the validation the market craves.
The technology works. AVA6103 is free at this price and AVA6000 in SGC alone is ascribed a chance of success around what did you put it at? 15%?
For a drug which is obliterating the PFS in an indication without a standard of care.
Those on the sidelines can sell it, buy it, short it. I don’t care.
I know what I hold.
As does a massive percentage of Avacta’s TVR.
The share price should be tapping on the door of 100p right now.
I’ve added today. Silence when Richard Hughes is sat next to Chris Coughlin is very different to silence without him sat on the Board.
I am surprised the market hasn’t grasped this