Member Info for TorquayFan

Scancell and Prof. Lindy on the button already . . . .

https://www.nature.com/articles/d41586-022-00063-0?

Thanks Konar - the discussion was re-ignited by retweets I believe.

Nice one Nom - that link works OK . . .

It's impossible to miss the point that 'World Class' movers and shakers such as CEPI, The Wellcome Trust and Sir Jeremy Farrar promote the need for universal vaccines and they ARE all aware of Scancell's 'Covidity'.

IF the RSA trial of Covidity has good results, we may have the Covid 'tiger' by it's tail ?

Cleaner - here's the passage from the DT that deals with Scancell :-

"A universal vaccine that would work on all Covid-19 variants by targeting the core of the virus instead of just the spike protein could be available in as little as a year, researchers say.

British scientists at the University of Nottingham are developing a variant-proof or "universal” Covid-19 vaccine which, if successful, would end the need to keep tweaking existing jabs as the virus mutates.

Existing vaccines like the Pfizer and AstraZeneca jabs target the spike protein of the virus, but their efficacy is expected to wane as this element of the virus mutates. Already there is some evidence they do not protect as well against variants containing the “E484K” mutation, such as those circulating widely in southern Africa and Brazil.

The new universal vaccines will also target proteins found in the core of the virus which are far less likely to mutate, meaning they would protect against all current variants and would theoretically have greater longevity.

Sir Jeremy Farrar, director of the Wellcome Trust who sits on Sage, the Government advisory committee, was among a number of influential scientists this week to suggest Governments' strategies should switch to more universal vaccines.

Backing an article in the influential Nature journal titled Variant-proof vaccines: invest now for the next pandemic, he tweeted: "We agree - and being acted upon by CEPI (Coalition for Epidemic Preparedness Innovations) and others."

UK company Scancell, which specialises in developing cancer vaccines, and several other firms from Europe and the US are already working on variant proof jabs and hope to prove shortly they can produce an effective immune response.

Alongside scientists from the University of Nottingham, Scancell is targeting a protein in the core of the virus called the nucleocapsid or “N” protein, as well as the spike protein. Human trials of their vaccine will begin in the second half of this year, after positive results from testing the jab on mice.

The DNA-based product seems to stimulate a good antibody and T-cell response. Scancell chief medical officer Dr Gillies O’Bryan-Tear, told The Telegraph: “We don’t necessarily claim it will be a pan-coronavirus vaccine, but it has got the potential to be so simply because of where it is targeted.”

https://www.telegraph.co.uk/global-health/science-and-disease/exclusive-universal-vaccine-can-conquer-covid-variants-could/

90% of airborne virus loses ability to infect in 20 minutes. Seems a very interesting new study : https://www.theguardian.com/world/2022/jan/11/covid-loses-90-of-ability-to-infect-within-five-minutes-in-air-study

Roses - I got past the paywall but Aug 2021 (?) and I couldn't see Scancell mentioned. Just this of interest - "Studies have shown antibody levels decline over time although scientists have not identified the level where they stop being protective. Other parts of the immune system, such as the harder-to-monitor T-cells, also play a role in fighting the virus" - looks like it predates the booster era. Sorry not being difficult, but did I miss something ? ATB

Whoops - 20,000 shots at 1.5 pence w/o the Pharmajet cost GBP300.
The sum was right, the typing wasn't. GNA

Oh joy !!
NO ads and the laptop speeds up too !

Thanks for the info. Bermuda. I am stunned. The Pharmajet Tropis just GBP 300 and will do 30,000 shots - that's a penny and a half write-off per shot, plus a mighty GBP 1 for the applicator. Less than a Pound all in - plus the cost of the vaccine. Now all we need is a viable 2nd Generation vaccine - any ideas?

I still wonder if Stratis and Tropis are likely to avoid Dr JC's concerns about 'aspiration' ? FWIW his concerns made good sense to me.

Thanks LLass. I agree but it would be good to see a fully costed comparison based on actuals.

Cutting out the accidents would be invaluable of course.

If you've seen a certain (Dr) JC talking about lack of 'aspiration', I wonder if Pharmajet bypasses that, (which makes sense to me), or not ?

ATB

Thanks Johnny - that's $ 12.3 billion, (on the link it looks like $ 123 billion).

Whatever that's amazing. I wonder how many treatments can be administered with one device, before they wear out, what maintenance costs are and how much the OEM device costs? And how will the costs per jab compare with needle injections?

Pharmajet looks like a great way forward to me.

BOJO your memory must be bad, I only posted on Sunday. A post like yours doesn't help - it just whips it up.

I posed a simple question on Sunday, actually relevant to the topic of the moment in which Investors here ARE concerned, and the rest is history.

I would be interested if you have anything to say regarding the original quiet presentation of some worrying facts. Why worrying ? Well, because the mistakes go on. But it's best at the weekend IMO. ATB.

Thank you Guys - works like a dream !

I WAS seeing about 2 lines at a time . . . .

Cheers and ATB

Gazza/Ruck Rover, (aka the waverider) - Mon 08.26 re. comparative dpm's - "This is almost certainly down to the fact that Japan has one of the lowest obesity rates in the world whilst the UK has one of the highest". Wow ! That's a very bold conclusion. The UK's dpm is FIFTEEN times the dpm of Japan - and it's due to the UK obesity? Dream on.

Japan has almost twice the UK's population at a higher density of 334 per km2, (UK 270 km2), and a very close GDP per head. Obesity - have you never watched Sumo LOL ? The very idea that 'obesity' as you say, explains a 15 times differential is plain barmy ! Then you list potential factors affecting 'dpm' - perhaps some are relevant but it would be foolish to conclude that these factors exacerbate and never work the other way in these comparisons.

In your quest to point out the 'erroneus' thinking of others, I suggest you should consider your own statements a little more. My original thought, (no hindsights), that Govt's. policies re. border controls, mask wearing and the closure of superspreader events, might be the reason for Nations having such dramatically different dpm records, might actually hold some water. I agree that 'recording' differences will in some cases be significant.

That said, just for fun, here's some more - the UK dpm is worse than New Zealand's x 219, Australia x 26, Japan x15, Thailand x7 etc.

Enough ! Don't start me off ! I need to read about Scancell so will filter you now.

ATB

It was recent Covid milestones prompted me to post.

For me, no decisive factors have been identified here to explain the difference between 2193 dpm in the UK and say, Japan 146 dpm, another populous industrial Nation with high density population. Of course, it IS uncomfortable to think that we are not in good hands with this UK Govt. so, it's 'heads in the sand' I guess.

Myself I remain convinced that border controls, mask wearing and closure of superspreader events, have had decisive benefits in other Countries that have suffered far fewer deaths than the UK.

That's it. Back to Scancell. ATB

Thank you Matt.

Thank you RW for your usual kind and helpful input.

In pursuit of balance again, here's part of MY reply to EE's post - "Yes EE and I hope you had a Happy Sunday too and btw, you may be surprised to learn I frequently vote Tory myself - I assess it at each election based on what I see."

That's a fact and I hope it makes it clear enough for you RW.

Nothing to do with right or left. Just facts.
Deal with it.
(Posts crossed). ATB

'Slaughter' C7 - how do you make that out ?

Just presenting some facts and asking a question . . . . any answers ?

Nope ! The truth hurts they say . . . Good night and TCOY and BFN again.

Here we are again - Omicron - news coming from all directions in RSA has emphasised from the start that Omicron was milder in it's effects.

" ‘There are several things we don’t know about omicron,” a sombre Professor Sir Chris Whitty told the nation in the week before Christmas, “but all the things we do know are bad.”

His comment puzzled many people at the time, given that scientists in South Africa, where omicron was first identified, had reported that it appeared to be less severe than the then-dominant delta variant of Covid. Surely that was good news?

Three weeks on, Sir Chris’s determination to dismiss the encouraging data coming from South Africa seems even more baffling. Instead of the post-Christmas lockdown that came to be regarded almost as an inevitability, Covid rules are now being eased. The NHS did not collapse, and the number of patients requiring ventilation remains less than a quarter of the peak a year ago.

Legitimate questions are now being asked about why Britain was so dismissive of the evidence from South Africa, and whether Government scientific advisers are once again using fear as a method of control.

One of those who is doing the asking is Angelique Coetzee, chairman of the South African Medical Association and the first doctor to raise the alarm over a possible new variant, which turned out to be omicron.

Dr Coetzee was among those who reported that omicron caused “very, very mild” symptoms compared with delta, and she hypothesised that it “could potentially be of great help to us” by replacing the more dangerous delta variant and helping the population to reach herd immunity at minimal cost to life. She says she was “astonished” at the panicked response to it in the UK."

On the one hand, Whitty advises it's 'all bad' and on the other, BJ, trying to hold his feeble Govt. together, fails to muster even the merest actions to proscribe 'superspreader' events, ensuring that although Omicron is NOT too bad, we'll anyway push the NHS to the limits.

Following the science - Ha Ha ! Chaos more like.

https://www.telegraph.co.uk/news/2022/01/09/must-listen-south-african-scientists-omicron/

Into Year 3 of the Covid crisis and the the UK has crossed a tragic marker of 150,000 deaths. In terms of 'deaths per million' the UK (2193 dpm) stands below the USA (2575 dpm) and much of S.America and E. Europe BUT still well above other major European Nations, despite Kate Bingham's massive VTF triumphs, well supported by BJ's Govt..

The UK's 2193 dpm looks sad against say, Thailand 311 dpm, Japan 146 dpm, Singapore 141 dpm, Australia 91 dpm and New Zealand 10 dpm. Of course there are differences in environmental factors around the World, but, nevertheless, these disparities, nearly 2 years hence, are mind blowing, to say the least.

Policies of border controls, mask wearing and the closure of 'superspreader' events were scorned by some here. So I wonder if there are now any suggestions to explain these disturbing differences.

As observed before the days of hindsight, it's hard to conclude that this UK Govt has managed the Covid crisis well, despite the overwhelming advantage of being first on the vaccines track.