BioNTech again . .5 Feb 2022 04:02
Perhaps there will, one day, be more active interest in Scancell's science from our friends in Mainz. Now massively profitable and I daresay, rather cash rich, might BNTX embrace some of Scancell's wizardry or pursue different paths ? (and not just with cancers - I wonder if they might be a partner for 'Covidity'?)
Coming back to cancers and Car-T : ""“The potential impact of CAR T is tremendous,” says Nirali Shah, a paediatric haematologist at the US National Cancer Institute in Bethesda, Maryland. This study “gives you a proof of concept about the safety of having long-term persistence and integration of the T cells into your body”.
It remains to be seen, she adds, how well the findings from these two individuals with chronic lymphocytic leukaemia will translate to other diseases. Efforts are under way to use CAR-T-cell approaches to treat solid tumours, such as prostate tumours and the devastating brain cancer glioblastoma. In January, researchers reported success in using the cells to destroy scar tissue in the heart — an approach that could one day be used to treat cardiac fibrosis2.
"CAR-T-cell therapies involve removing immune cells called T cells from a person with cancer, and genetically altering them so that they produce proteins — called chimeric antigen receptors, or CARs — that recognize cancer cells. The cells are then reinfused into the person, in the hope that they will seek out and destroy tumours. In the years since Olson’s treatment, five CAR-T-cell therapies have been approved by the US Food and Drug Administration, to treat leukaemias, lymphomas and myelomas. June estimates that tens of thousands of people have received CAR-T cell treatment. But the therapy is expensive, risky and technically demanding. It remains a last resort, to be used when all other treatments have failed.
“The potential impact of CAR T is tremendous,” says Nirali Shah, a paediatric haematologist at the US National Cancer Institute in Bethesda, Maryland. This study “gives you a proof of concept about the safety of having long-term persistence and integration of the T cells into your body”. It remains to be seen, she adds, how well the findings from these two individuals with chronic lymphocytic leukaemia will translate to other diseases. Efforts are under way to use CAR-T-cell approaches to treat solid tumours, such as prostate tumours and the devastating brain cancer glioblastoma. In January, researchers reported success in using the cells to destroy scar tissue in the heart — an approach that could one day be used to treat cardiac fibrosis2."
https://www.nature.com/articles/d41586-022-00241-0?
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