RE: Aptamer versus Affimer22 Oct 2020 06:52
Kainos, interesting comment from Carl!
What I do know (as a shareholder in Avacta):
1. MHRA Guidelines
Acceptable Sens > 80%, Spec > 95%
Desired Sens > 97%, Spec > 99%
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/895745/TPP_Point_of_Care_SARS-CoV-2_Detection_Tests.pdf
2.Sona Nanotech initially declared for their LFT a externally validated sensitivity of 96% and specificity of 96%. Reasonable performance against MHRA guidelines. However, during clinical evaluation of their LFT, the figures dropped to 84.6% for sensitivity and 90% for specificity!
https://investingnews.com/daily/life-science-investing/biotech-investing/sona-nanotech-announces-clinical-evaluation-study-results-for-its-covid-19-antigen-test/
In simple terms, wrt MHRA Guidelines, not good enough!!
3. Avacta promised a LFT mid Summer. To date, NO sensitivity and NO specificity information has been officially released. NO in-house,
NO independent and NO clinical validation sensitivity and specificity data has been released. Why?? Someone, claiming to be a former employee at Avacta, stated on the AVCT BB, that manufacture of a LFT is difficult. The slightest Production variation causes a marked change in Sensitivity and Specificity performance outcome of the test! Is this the reason, Avacta have deferred release until Q1 2021? Who knows? (Probably the MMs - LOL!!!)? However, a delay is a delay and Q1 2021 just happens to be when Carl's test is available for roll-out!
4. Avacta's CEO (Dr AS) has stated that no one Company has the capacity to supply the covid test demand. Hence, my statements on this BB that no one supplier will have a monopoly. Essentially, all good tests are needed.
However, some tests will inherently have better clinical performance.
Carl's test is very fast (tick), sensitive (tick) and specific (tick). Listen to the Proactive interview:
https://m.youtube.com/watch?v=-M0O-JFoFUc
Carl's background, tells me he knows his stuff! He is not some Aim CEO wanting your money!!
In Carl we trust, was a title of one of the threads on this BB. Well, for me the POC outcome and my investment was always binary. So I am willing to become a LTH!
"Trust in the force" springs to mind. If everything works out we have a multi bagger here based on market cap.
Worth being a LTH in BRH?? Absolutely!!
Hold for gold!
DYOR!
Carl's test - Speed (tick), Sensitivity (tick), Specificity (tick)
Test, test, test