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https://www.sciencedaily.com/releases/2022/06/220606111527.htm
As most lths here know i believe over half of disease is caused by immune. Why im up to my nuts in tyk2. Even i am shocked by schizophrenia though.
An5ibodies are a different therapeutic area. And dont seem to work against tecent variants. Plus intravenous so ties up a hospital bed and a nurse.
Tigit is dead as a class imho after some **** poor results from roche last month. Hope that helps.
So plenty of academic 0apers on wee1 and chk1 working synergistically.
Zentalis have the most advanced next gen wee1. In the clinic with some impressive ovarian data. They are doing a combo with niraparib next.. .... worth putting on the radar.
Im a bit whatever on the cta.
More interested in gsk 737 plans which i guess we wont know til august. But if they so combos in multiple indications we c9uld get very minted. Next 1802. I suspect p1 will be cheap (20 people) and possibly sick people in p1 due to lack of current treatments.
1801 will just trundle at its own pace but without a deal dont see much sp effect of this for some time.
So the boring stuff. Sta737 only chk1 inhibitor still alive. Udai bannerji has been in charge of trials on 737. Marsden and cruk funded role. Kras very interrsting. 737 used to be cct245737. Several papers on ddr and kras cell death. Ian collins author. Now cruk. Used to be a sareum employee years ago. Lots of dots ....
Those of us who have been married. Recognise 10% of the population are mentally ill. The bbs are no different and almost a magnet for those stuck at home. To display obsessive paranoid behaviour. Unfortunately we just have to suck it up
My tuppence worth ;)
As colbalt has been a holdef for ten years he must be absolutely minted like the rest of us.
Now in the endgame i think.
https://youtu.be/f3dI_g9N-ks
Rock out with your **** out. Nearly there xxxx
Galapagos woth a look at long term share chart. Same with archageon. Salutary lesson as to why most of us will bail out before any phsse 3 results. :) long time til then to go though.
On a personal note im being discharged from hospital today yay. Ps re gentyx. In the back of my mind they dont have a patent in tyk2 but stll have a massive valuation.
If gsk progress chk1 combos. I think they will get some accelearated approvals. My fad packet is 2bn mcap just off chk1 royalties. Some big ifs and some patience reqd. Tyk2. Think otezla sold 12bn just for psoriasis but an approved drug. So im sort of 2bn to 20bn mcap depending on ifs and buts and timescales. But happy to wait to realise full value. Whats another year ?
dull but highly relevant and has put me in hospital for the last 2 weeks.
short version... dead covid virus can linger in the digestive system (and other organs ) for 6 months after clearing from lungs. Leading to an over stimulated immune response (needs our tyk2 obvs) causing temporary IBS. bloody horrible spend all day on the bog.
https://www.rcpjournals.org/content/clinmedicine/early/2022/02/01/clinmed.2021-0522.full.pdf
in my case this led to a complete loss of sodium. which led to an inability to regulate fluids, which led to 2 kilos per day fluid gain. yep 2 kilos per day. 2 stone in a week. now under control thank goodness and wont kill me. but an example of overactive immune and the problems it can cause if untreated. on the mend now and should be out in a few days, no lasting damage.