Member Info for ThinShins

Thanks a lot for sharing your research, based on what you are saying it fits who I thought could also be one of the likely conteders. Sonic Healthcare / Health Services Laboratories / The doctors Laboratory.

Hi Neil, would the very likely contender be Synlab / Synnovis? I’m leaning towards them being the “provider” referenced in the LOI. I have my reasons why which you can find in my previous posts.

FWIW

Gemini gave the below when I asked it how this research could relate to CIZ1B test.

1. Proof that it's an "Early Warning" Signal

The text notes that CIZ1 abnormalities are elevated "even at stage I." This is huge for lung cancer. Lung cancer is notoriously hard to catch early because patients rarely have symptoms in the beginning. This research confirms that CIZ1 glitches happen at the absolute dawn of tumor development, validating CIZ1B as a highly sensitive tool for early detection.

2. Cross-Cancer Potential

While the CIZ1B test was specifically tuned for lung cancer (looking for a specific variant of the protein in the blood), this paper shows the underlying mechanism also drives breast cancer. This means the science behind the CIZ1B test could eventually be adapted into early-detection blood tests for breast cancer and potentially other tumor types.

3. Predicting Aggressiveness

Because the text explains that the CIZ1 AD piece causes "epigenetic instability" (widespread genetic chaos), measuring the amount of this abnormal protein in a patient's system might help doctors predict how fast a tumor is likely to grow or change, allowing for more personalized treatment.

I'm not going to pretend to understand the research and how it could potentially apply to CIZ1B test but there was this piece of research published by Prof Dawn and her team regards to CIZ1 and early stage breast cancer

https://rupress.org/jcb/article/224/5/e202409123/277316/Epigenetic-deprogramming-by-disruption-of-CIZ1-RNA

Https://www.independent.co.uk/news/science/early-cancer-detection-tiny-device-blood-b2982954.html

"Chinese scientists build hand-held device to detect early cancer signs from drop of blood"

We need to launch ASAP

Https://www.omnihealthdx.com/

Their logo has changed to now show "powered by Katharos Health"

Cant find much info about this Katharos Health

Https://www.cizzlebio.com/educational-articles/should-you-be-screened-for-lung-cancer

From Cizzle Bio's latest blog post: "The test will be available soon to licensed U.S. healthcare providers through our CLIA-certified laboratory partners."

Partners plural not partner singular, is their another lab coming onboard in addition to Omni?

Further bread crumbs that lead me to believe its Synlab/Synnovis.

LOI mentions " The LOI covers the verification and validation of the Company's CIZ1B biomarker test with a NHS Foundation Trust partner in state-of-the-art laboratories"

https://www.synnovis.co.uk/about-synnovis

"Synnovis is a partnership between SYNLAB UK & Ireland, Guy’s and St Thomas’ NHS Foundation Trust, and King’s College Hospital NHS Foundation Trust."

"Synnovis provides services to the NHS"

"A state-of-the-art ‘hub’ laboratory has been opened as part of this transformation at Friars Bridge Court, in Blackfriars Road, London, bringing cutting-edge instrumentation, technology and innovation together under one roof."~

Https://www.synevo.si/images/Brosure/Group-Image-PPT-2024.pdf

Anybody recognise the wording on the first page of the above pdf? if not maybe have a read of the LOI RNS from 05 November 2025

When CIZ released that RNS surely the "provider" involved went over it and had had major input in the wording and phrases used.

If you research Synlab/Synnoivis its really exactly the perfect fit to what the LOI describes. Synlab are also a pan-european company which could eanble a EU rollout.

FL commenting on a post 1 day ago:

"Cizzle Biotechnology plc has a simple blood test with 95% accuracy for early stage lung cancer detection.

Which will hopefully be available to USA clinics very soon!"

While we all hope for a successful outcome for this share for the sake of both patients and our own pockets, it’s important to stay grounded. Be cautious around the 3 rocketeers frequently making big/bold claims. They seem friendly and genuinely enthusiastic, but it’s always best do your own research and keep your feet firmly on solid ground.

What is everyone thinking in regards to timing of RNS when the test is launched in US?

Will CIZ RNS in morning and then followed by BIO announcing it.

OR

Will BIO announce it first and then CIZ will RNS intraday?

Which website?

There’s 3 rocketmen here I suspect they could be the same users with different usernames over on ADVFN

Https://www.prnewswire.com/news-releases/cizzle-bio-submits-nih-grant-proposal-with-premier-research-institutions-to-advance-biomarker-blood-test-for-lung-cancer-302499438.html

we were also supposed to hear about the nih grant application. ********************yuykm346

from 2025 "cizzle bio anticipates a response from the nih later this year."

Zen19 does like a rocket. There's a few rocketmen recently been visiting here.

Sharemans what do you mean when you say “confirming US alliance” ?

Hi Sharemans,

What makes you believe another US partnership is due to be announced?

“Under the terms of the LOI, a validation exercise was conducted with on-site technical support under the

guidance of Professor Coverley to confirm assay performance data. The completion of that programme

towards the year end lays a solid foundation to develop that relationship into future revenue generation in our home market.”

The above is from the results published earlier this month, seems as though the initial validation exercise was completed late 2025.