We would love to hear your thoughts about our site and services, please take our survey here.
You're trying to imply RM ever suggested SNG was inneffective as a home-based treatment? I don't believe he did, or that the science supposedly supported that. Seems like a nonsense statement to lower the share price. You could find a quote to disprove it though. What he probably meant was that, using the fire analogy, you don't send a fire engine if the home owner can douse the flames with a bucket of water (ie if people get better on their own). So it needs to be more targeted. Not that it is ineffective or harmful taken early - the home trial results certainly did not indicate that.
Or target both early inpatient and targeted outpatient maybe? Anyway, I haven't looked into the Canadian trial really, so was just making a general comment (it'd be nice if you're wrong about it though).
What would be a shame (for sufferers, and shareholders of course) is if SNG is both very effective as an outpatient treatment and a 'welcome to hospital, have some interferon' treatment, but doesn't get approved and widely used for Covid or any respiratory issues, and doesn't get approved as a go-to treatment as part of planning for any future pandemic (hopefully a future pandemic isn't on the horizon anyway but there's been plenty of talk about that possibility, learning lessons, being ready to respond). It would be surely perplexing as well as a shame if that was the case too.
Highly effective and statistically significant are not the same thing Doc though. If everyone taking SNG early enough survives Covid then it is highly effective, and practically significant/notable. It is very likely more effective early rather than late isn't it? I'm not trying to over-rule everything you're saying but to say it's definitely not highly effective is misleading - haven't you said before if there was a point where the virus (Covid or another one) became more deadly again, percentage wise, then SNG could become a significant early stage treatment? Should targeted early stage treatment be ruled out (to cut down on hospital visits, make it more likely people survive), if it's feasible it to think it works a treat (in preventing deaths, and cutting down on hospital visits substantially)?
Sorry, maybe I shouldn't have replied - I had said I had finished posting here now. But yes, another point is that the trial results are based on a quick take-up of injections after infection aren't they - that seems an unlikely 'catch all' in the real world (I don't know how feasible a Synairgen inhaler is scientifically, comercially and in terms of proving it works in a quick time, but I'd think that would be a more likely route to getting people on board in taking something before they are ill, but anyway we need to see the detailed data for the admission via nebuilser at earlier stages like I said, and we know it has some positive effect after 7 days have passed too, when patients are already in hospital even if Phase 3 didn't show it as well/conclusively as planned or hoped).
All the best everyone. Obviously I'm not against a Covid treatment being effective, but sometimes it seems like people will try and show any trial result as a 'game over' scenario for Synairgen and it probably winds me up a bit!
Who wants to be injected rather than use an inhaled method? You haven't seen the data for pre-hospital Synairgen performance yet, but it would seem very possible that it will be better than 25 hospitalisations. Activ-2 data might give some pointers for a comparison when it finally arrives. So maybe hold your horses? If it was zero hospitlisations with such a trial that'd have been really significant and genuinely worthy of being 'the treatment' I guess, but 25?
I am struggling to understand the hold up/lack of urgency in terms of Activ-2 results being made available. I guess it is logical to expect that the trend showing a benefit for breathless patients is likely to have been replicated. I would hope the zero deaths figure would be replicated too. I don't want to encourage people to risk more money if they are already invested heavily (I did average down with a small amount a few days ago though eventually myself - so if we even got to £5 somehow then it'd be as much a result as much larger figures would have been before Phase 3 results day), but trying to look on the hopeful side I guess we are one set of impressive results away from a recovery in share price and a renewed possibility to get this out there to treat Covid still, whether it's for a certain subset of patients, or potential patients, or for those at a certain stage of illness (I assume Synairgen's effectiveness will outlast that of the Pfizer pill, not to mention lacking risks that come with that about variants and using with other drugs). I think it's got to be a hold rather than a sell in general right now surely anyway (unless someone really needs money quickly or has another investment in mind, or just wants to reduce their investment albeit take losses on the shares they well right now).
As always anyway, all the best to everyone.
Since it was betting that got me in a position where I was hoping to recover losses with Synairgen's help, I won't give any tips lol, although if you see anywhere offering this accumulator as posted by Doc (as a list of what else could possibly go wrong from here) it could be worth £20, to cover us from both sides (this is only a joke by the way!):
- merely average ACTIV-2 P2 data.
- no positive data from the SPRINTER P3 deep dive analysis.
- no decent long Covid results.
- Polygon selling out (IMO opinion unlikely, but you can never be sure, especially so if their rationale for staying in was ACTIV-2).
- fund raise (I think they will need to offload some of the expensive senior recruits from 2021 to avoid this).
You can't say it is not as good as SOC Emma because there wasn't a trial comparing the two. All that can be said is there was a trend that showed a liklihood that SNG helped with severe illness and prevented deaths, compared to if using SOC alone (when both were used together). The analysis will show more in depth findings I guess.
Meanwhile it's long been said that interferon will be more beneficial the earlier it's administered. The home trial was certainly not a fail in terms of prevention of illness, it just lacked high numbers of problems on the placebo side too.
And SNG seems to be potent against all variants.
It doesn't seem like it's all over yet to me, and I don't know why you, Dumbpunter etc are trying to convince us it is. Is it for our own good? We should all sell up at 25p now, and rescue a very small percentage of our investments? (I'm not saying invididuals might not decide that's the best course of action if retrieving the amount they can would still make a significant difference in terms of how much they can afford to lose obviously - or sell some and retain some just in case of whatever - anyone in that situation might already have done it though by now).
- I don't think RM is suggesting steroids inhibited SNG as such (not that that wouldn't be a relevant thing to look into obviously), but more that they improved placebo results - "This improvement in patient care may have compromised the potential of SNG001 to show a clinical benefit in respect of the endpoints for this study, which were not met"
- RM and Prof Wilkinson are not saying it's all over (although unless the 90 day data shows something more significant does it seem like proving efficacy in hospital patients will be a long haul if new bigger trials are what is being suggested?), and the main hope seems to rest on Activ-2 progression - hopefully the phase 2 results can be shared ASAP, first with Synairgen and then with the rest of us - "In the meantime, we eagerly await the Phase 2 data from the US NIH ACTIV-2 trial in home- based COVID-19 patients, and that trial's larger, follow-on Phase 3 study, as part of the development path for SNG001"
Keep your chin up Alwayslate7 mate: a lot of us are in the same boat and have lost (on paper for now at least) a chunk of money (for me it's not a huge amount but given how much I've got it's not unsubstantial and I was really hoping, almost expecting, I'd received payback to at least wipe out the first significant gambling losses of my life - again over a few years I suppose it wasn't a lot but it did feel like giving away money for nothing due to a combination of being too risky and a bit unlucky initially and then chasing losses and perhaps suffering a bit of harsh treatment on exchanges from Market Makers of the sports betting variety too!).
I think everyone should try to look on the bright side, and be thankful that Covid hasn't cost us our lives for example, and if it's cost us money and we don't get it back we'll have to live with that. I don't think you are stupid, and your post indicates you care about your family and I imagine you are well loved and respected for that!
I think I'm just going to wait and see what happens with Activ-2 now. No guarantees that will have a better outcome, but there might be some grounds for hope. Everyone needs to decide for themselves but if you haven't sold yet I'd think it might be worth holding on a while rather than giving away shares for virtually nothing.
0 deaths on SNG might have at least given a good headline, though there is an indication there at least that being treated with SNG did improve odds, and we know Dexamethasone was taken up on a similar basis. Maybe SNG can still be an optional hospital treatment? It was also said originally that interferon being administered ASAP gives the best chance, so perhaps Activ-2 will still show that?
All the best everyone.
I'd rather believe they are waiting for the 90 days so as not to bias responses (legitimately timing the completion of analysis to meet that goal - maybe they know the analysis of SNG019 will be very quick and that's why it won't delay results because they were not going to happen before the 90 days) than they are allowing Polygon to steal investors shares by making them nervous! And the integrity of Sir Stephen and Richard surely makes me believe the more palatable explanation is indeed much more likely. I'm not selling any of my 220 shares to them anyway lol!
Nevertheless it's understandable he wants to feel assured his money is safe (I agree we have to accept it's possible it's not going to be when we invest and so shouldn't over-do it, but we all want to know ASAP that the shares will rise in value, the Phase 3 results are good, the product will be used and will help Covid outcomes significantly etc, and the only time we will know that is when results are actually announced so it can lead to a level of stress in return for the potential reward on the other side of the equation).
Surely proceeding against "standard of care" (i.e the normal treatment for those not receiving SNG, including dexamethosone etc) makes sense, although hopefully Synairgen's EUA comes well before Activ-2 is due to complete anyway (but Activ-2 can be useful in making the case for home (pre-hospital) use of SNG I'd have hoped and thought since the data was good enough to progress to phase 3).
Anyway, I'll bow out now myself - I just felt if nobody else was going to say that then I would, but I wish everyone the best with their investment (to be fair if I want to make any money myself I'd have to anyway though I suppose lol!), and for you all to have a happy and healthy new year while Synairgen really makes a difference. Sorry if I did make too many political points but sometimes I think it's less a matter of politics and more about what's right and wrong (I can't deny I've had some hard times myself although I did used to hand out spare change often enough to charity collectors, homeless people etc even before then so I don't think my sentiments are all based on my own perspective - clearly TLWilliams did say himself he tries to help people when he can though which is why I thought if he understood a bit more of what was going on he might alter his views somewhat at least).
I for one appreciate (a lot!) what Hold4Results was trying to say, but I accept that whatever Axe originally said may have been at worst ignorant of the situation around benefits claims and what happened when David Cameron and George Osbourne got hold of it. Hold4Results you shouldn't have to apologise for those comments about the 'system' and you already did apologise to Axe so I'd like to think you'll be given some slack for your heart being in the right place. All the best to you.
Here's hoping your strategy (holding for results) is about to prove very wise too!
Haha, I think Jwd didn't exactly predict £25 Fruits to be honest (it looks like he was suggesting that the predictions for the share price to eventually reach between there and £75 are ambitious and he's not having the ceiling being any more than £20), but it'd be funny if he was spot on and got the kudos for it (I don't think any of us would complain!).
Put me down for £7.79 anyway (at which point I might start thinking about parting with 60 shares or something, but if we're expecting further rises with EUA etc I'm thinking we don't want to be in a rush to sell too many of our golden tickets as it were)!
Or (based on Phase 2) the chances of dying have been reduced by 100% (like I alluded to of course it would be brilliant if that held for phase 3 too, but it could be a big ask, even with mega effectiveness, as some patients may have started treatment later than others or already been in a very critical state potentially I guess).
Ok, thanks for the reply ProfSH. For me your analogy applies more to flu or something and Covid seems more dangerous for relatively active and healthy people (hence the numbers that would have died without any lockdowns at all). Plus, many people are far from ready to die and so shouldn't be put in a situation that makes it more likely to happen, without protection. It can and has affected many younger people too, even without obvious comorbidities (although not percentage wise - I understand most young people survive it, which then brings into question all the vaccinations that don't even halt transmission, given vaccine deaths and injuries can and are happening even if again not in large numbers percentage wise - it's just that small percentages of nearly everybody is still a big number - remember that 96 people died at Hillsbrough in 1989 and that was an avoidable tragedy). Anyway, all the best to everyone and Happy Christmas (to follow HeleB's positive lead on this). I've only got a pretty small investment, but it would help me out if the share price multiplied many times for sure. I'd agree with others that we shouldn't invest beyond what is affordable to lose though.