Member Info for Sangijuelas1

Gives an explanation of how the algo trades can be stimulated, according to various indicators.

They also used sentiment analysis tools which can capture the mood from various social media platforms like LSE and Twitter!

https://www.morningstar.co.uk/uk/news/194922/algorithmic-trading-in-the-spotlight.aspx

Check out this site which monitors Twitter and Reddit. This is for Joe Public. Imagine what the hedge funds must have.

https://socialsentiment.io/

It's not a fund Porky. It's just Oliveira's investment vehicle.

And yeah I realised the other day that he took the whole loss on Forte once the bad data was out.

He's a very shady character.

It's just a P1 trial to get safety data.

The more safety data in the more patients the better.

Get a new script. The one they have given you is really weak.

I thought you were worried about immunogenicity.

Now you are saying they are inherently safe. I am confused.

They seem to have given you a good script for SNG but here they seem to have let you down

Immune Checkpoint Inhibitors (ICIs) work in a fairly small group of patients 20-35% depending on the therapy and the form of cancer. And in about half of these responders after a while they stop working usually as a result of immune system exhaustion.

One important way ICIs can stop working is when resistance to them is acquired due to excessive Tregs which suppress the anti tumour response.

"Achieving depletion of regulatory T cells while sparing tumor-specific effector T cells has long remained an elusive goal of immunotherapy" .

https://www.nature.com/articles/s43018-020-00155-8

The biomarker data from Part A of 4Ds MRX 0518/Keytruda trial showed that responders had higher ratios of Tregs to tumour killing cells in the tumour.

MRx0518 works by suppressing Tregs and making cancer killing cells proliferate.

There are various ways being studied to achieve Treg depletion and it is a major goal of Big Pharma. Most of these efforts are in the very early stages, or have had inconclusive results or have been shown to have toxicity issues.

An example of one is the anti CD25 monoclonal antibody developed by Tusk Therapeutics. Roche bought Tusk for $759m and they only have it as a P1 trial application.

Getting more conclusive data from Part B of the 0518 trial would represent a major medical and scientific breakthrough in the field of ICIs.

So last year you were concerned about immunogenicity but now you're not?

Almost like you don't know **** and someone else gives you your lines.

It's the buy/sell momentum that drives the auto trades. Read about algorithmic trading and short selling.

So you would have more effect splitting any large buys up.

Of course a 100k buy would have little effect.

By the way can you get a quote? When it was 40p the other day someone was quoted 44p for 100k

Mumble Bumble I am still waiting for you to give your thoughts on Treg mediated acquired resistance to immunotherapy

Did he lose $50m on Forte or not?

Was he leveraged? Is he meeting margin calls?

Oliveira is not the auto trades. He dumps with the O trades in 10,20,50k or more batches.

These then stimulate the auto trades sells

There were months where nothing happened and the price just oscillated between 80 and 90p driven purely by the auto trades

The auto trades are shorts selling between themselves. It started when 4D got listed on the Nasdaq pink sheets about 2 years ago.

They are supposed to be used to boost liquidity but as with any market tool they get abused.

The only way to get them in reverse is a fund or big investor sustained buying. Retail buys won't do it by themselves.

Why are you in such a rush to see a return if you are so wealthy?

Sounds more like you are over leveraged with a spread bet

It's fine saying do your own DD Phil but how can people when they don't have a scientific or medical background?

It's taken me 4 years of continuous research to get to the point where I really have confidence in what is going on here with the company.

They released the ESMO data last year and it's only really now that I get the significance of it and how the 2 papers relate to each other.

The company has a drug discovery platform that has already put 4 candidates into clinical trials in 8 years. With 3 more lined up and ready to go.

Even if 0518 does not achieve the 10% efficacy seen by Merck as clinically significant there is still the fallback potential of Blautix, Thetanix and the asthma drug.

What other small biotech has partnerships with not just one but two major pharma cos in Merck and Pfizer?

At the moment the company is in the unfortunate position of being classed as a micro cap, which means that mainstream funds won't touch it. They are scared to death of getting into trouble like Woodford did and are wedded to income generating companies.

I get that you are scared Porky.

You invested without knowing anything about the company. You thought Blautix was the main candidate and you didn't know there was a persistent seller since September last year.

Must have been a bit of a shock when you couldn't pump it to get your 20%.

Are you really incapable of holding a stock when it's down.

I was underwater with Tesla and there were a lot of shorts and naysayers. Every day was another day when analysts would predict the companies demise.

Thankfully I didn't sell.

Porky you know nothing.

It's not a fund.

It's his investment vehicle. The money is his.

He is banned from carrying out brokerage activities.

Good riddance. Get him the **** out. I will buy what he dumps.

Only £3-4m to go now

There's no reason for the price to spike on today's data. It's just a bit more detail on the asthma trial that was already reported positive before Xmas.

First Mumble Bumble then the Fat Pig

It's like swatting flies

There is no 27p average.

He initially loaded up in March 2020 when the SP dropped as low as 25p for a brief period before bouncing on news of a Covid trial.

When there was a placing at 35p he took part and then again when the 110p placing along with buying up a significant part of the Longevity shares for $10.

His average would probably have been in the 50s.

He is still selling because he lost $50m when Forte Biosciences collapsed

Porky I have been invested here for 4 years. The auto sells have been in play for the last 2 and have only reversed when there have been sustained rises.

As people predicted you have now turned against the stock and are spreading lies that Oliveira bought all his stock for 27p.

I just feel sorry for the people that take you seriously.

I

And Porky shows his true colors.

You were warned about him. They felt so strongly about him that they were stalking him.

And here he is spreading the lie that Oliveira accumulated 20m shares at 27p without causing the price to rise.

Thanks RP. I was looking again at the Imperial College network yesterday so will have a watch

Any thoughts on overcoming Treg mediated acquired resistance to immunotherapy?