RE: Morning28 Apr 2021 16:12
Hi Ruck
Yes, the non-staring of both the SCIB1 and the Modi1 trial have frustrated us investors for a number of years.
Again, for people new to Scancell, the Modi1 trail is awaiting confirmation that the manufacture is complete. This has been a long and difficult process due to the 3 conjugates making up the vaccine being hydrophobic. The last we heard those problems had been overcome, and there just remained the combining of the 3 conjugates. So this appears to be the last hurdle before the trial can start.
Again it will depend upon getting the green light from the trial centres.
To my knowledge, a list of the centres has not been published. Having said that, Scancell have created a clinical advisory board (CAB) comprising 6 clinical experts so maybe the working locations of these 6 clinical professors gives us a clue.
In phase 1, as well as determining safety and best dose, immune responses are sought from 4 hard to treat cancers. These are currently head & neck, triple negative breast, ovarian and renal cancers. If a suitable immune response is found in any of these cancers, this will result in a phase 2 trial for that cancer. So the trial could branch out into up to 4 phase 2 trials.
I would be nice to get this trial going soon since it could be a real game changer.