The expert who just spoke on BBC TV said that anti-virals are ineffective once inflammation takes hold. Boris’ headline grabbing goes for completely the wrong target!
It’s Foralumab and SNG every-time for me!!!
Politicians... they probably have BOGOF on the useless Remdesivir.
Yep, we are talking about politicians here.
...comments redacted.
Hi Folks
Interesting read:
FDA Revokes Lilly’s bamlanivimab EUA As Its Efficacy Wanes Against SARS-CoV-2 Variants
:
I think the interesting statement is:
“
The FDA has determined that the known and potential benefits of the investigational monoclonal antibody when administered alone no longer outweigh the known and possible risks for its authorized use.
“
Full Article:
https://trialsitenews.com/fda-revokes-lillys-bamlanivimab-eua-as-its-efficacy-wanes-against-sars-cov-2-variants/?utm_source=Contextly&utm_medium=ChannelEmail&utm_campaign=COVID-19&utm_content=Notification
We urgently need a safer and more targeted/efficacious way to dose ALL mAbs, like the patented TILS platform! The results from the Brazil trial proved the TILS platform works, irrespective of the additional fantastic results for Foralumab (87% less lung damage).
Come on TILS.
Regards,
The rampant TILS bashing on this BB recently means only one thing in my mind, they know that TILS is long overdue a re-rate and want to scare as many innocent folks to sell their shares beforehand!
Don’t fall for it, hold on to your shares and reap the rewards to come!
Regards,
TILS BOD are also most likely sick and tired of the LSE sp games, so not a bad decision in my opinion. Hey, perhaps they will decide to delist TILS and move everyone’s shares to NASDAQ as well! Ha!
@fullfathomfive
I realised what you name stands for:
“Depth charges away!”
I reckon you are one of the chief manipulators... So what price have you set TILS up for next week, during your last golf session?
Well it’s a classic de-ramp tactic to bash the BOD.
I don’t know any share that has had a significant patent application granted where the share price hasn’t increased significantly. Patents are a defining contribution to share value. In fact I feel so strongly now that this share is being manipulated I may even take it up with the FCA.
Regards,
You chaps are really pushing the boat out now aren’t you to bash TILS. This is totally outrageous now, and no mention anywhere about the amazing implications of that new patent (years in the making) which will quickly being in revenue.
If you think you are going to get any more of us LTH to sell our shares then you can all
GO JUMP IN A LAKE!!!
WE ARE NOT SELLING SO GET LOST!!!
Unbelievable!!!
A new patent, fabulous!
That is a real, undeniable reason for a re-rate!!!
Regards,
Hi Levs,
I am with ii and I can hold foreign shares in both my ISA and SIPP, you just need to fill in some US tax type forms saying you are a private investor. There are no rules stopping you holding foreign shares in your ISA but it will depend on who you trade with.
Regards,
I don’t think it moved, other than the random quantum level fluctuations...
:(
Just re-posting a very in-depth Covid article from another LSE BB which has some interesting takeaways (if you can read through the heavy science), with some comments of my own (>>...)
“
the predominant targets of SARS-CoV-2 are the upper respiratory epithelium and lungs. ...The central role of the lung in COVID-19 is supported by a significant rise in SARS-CoV-2 viral load in these organs in more severe disease, which does not occur in stool or serum10. In 10-20% of patients, the disease progresses in severity with bilateral ground-glass opacities on chest computed tomography11. In the first wave of COVID-19, approximately 5–20% of patients became critically ill, requiring invasive mechanical ventilation due to acute respiratory distress syndrome (ARDS) with bilateral diffuse alveolar damage and cellular exudates on postmortem analysis12.
...Immunohistochemistry demonstrates the highest expression of the ACE2 protein within the sinonasal cavity and pulmonary alveoli, which are presumptive sites of viral transmission and disease development13.
“
>> Foralumab via nasal inhaler is directly targeting the sinonasal cavity, the upper respiratory epithelium and the lungs! Trial 1 CT Scan results showed 87% less lung damage!
“
Other studies, however, have reported no association between viral load and disease severity40. This is supported by a systematic meta-analysis of viral load dynamics in COVID-19 whereby no viable virus was detected beyond day nine of the disease, despite prolonged SARS-CoV-2 RNA shedding in respiratory and stool samples10. Furthermore, a postmortem study demonstrated disconnect between SARS-CoV-2 detection and organ inflammation and dysfunction41. Together, these results suggest that disease progression and mortality may not be directly virus dependent but rather driven by aberrant host immune responses.
“
>> That suggests to me that late stage treatments (most patients will be treated at a late stage) need to be immunity regulating and not anti-virals (as anti-virals have the best effect at a much earlier stage when the virus is replicating the most).
“
The balance between viral exploitation of host factors and the role of that factor in COVID-19 pathophysiology is not clear. Furthermore, ACE2 and TMPRSS2 genetic variants are not convincingly associated with COVID-19 severity3,82. Other important host factors involved in viral–host interactions, viral protein processing, and immune function are more likely to contribute to severity. The therapeutic effect of glucocorticoids, such as dexamethasone103 or hydrocortisone104, in decreasing COVID-19 mortality or the need for organ support strongly suggests an inflammatory process in severe disease.
“
>> Does that suggest Foralumab anybody!? Bingo!!!
The full document is here:
https://www.nature.com/articles/s12276-021-00595-x
Regards,
Sorry folks, long day. Very quiet here.
Regards,
There, now lets see if the share price climbs tomorrow by 5 * x (a very small amount)
:)
on the LSE BB...?
the number of different posts...
take into account...
the robot trading Algorithms...
I wonder if...
Who doesn’t want a 60 second breathalyser at the Hospital/Doctors/Clinic/Pharmacy that can diagnose 40+ conditions/diseases without any painful/scary needles or long waits and inconvenient hospital trips? This is as close as you get to a Star Trek health scanner!
I’m sold! Best Wishes, and you have one more eager LTH here who will be adding more over time.
Regards,