RE: 201 opposition28 Nov 2018 09:59
Keytruda....a solid drug, but not one that has so far had exceptional performance beyond a small subset of prostate. I quote
"Some 11 per cent of men with very advanced prostate cancer are still benefiting from the immunotherapy ‘checkpoint inhibitor’ pembrolizumab after a year – with many of them showing impressive remissions and prolonged disease control" Pembrolizumab being Keytruda.
Keytruda noted side effects:
"severe immune-related adverse effects including lung inflammation (including fatal cases) and inflammation of endocrine organs that caused inflammation of the pituitary gland, of the thyroid (causing both hypothyroidism and hyperthyroidism in different people), and pancreatitis that caused Type 1 diabetes and diabetic ketoacidosis; some people have had to go on lifelong hormone therapy as a result (e.g. insulin therapy or thyroid hormones). People have also had colon inflammation, liver inflammation, kidney inflammation due to the drug.
The common adverse reactions have been fatigue (24%), rash (19%), itchiness (pruritus) (17%), diarrhea (12%), nausea (11%) and joint pain (arthralgia) (10%).
Other adverse effects occurring in between 1% and 10% of people taking pembrolizumab have included anemia, decreased appetite, headache, dizziness, distortion of the sense of taste, dry eye, high blood pressure, abdominal pain, constipation, dry mouth, severe skin reactions, vitiligo, various kinds of acne, dry skin, eczema, muscle pain, pain in a limb, arthritis, weakness, edema, fever, chills, and flu-like symptoms."
VAL201: G1 mild Arm rash?
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