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Someone just punted £12k + £7k within 20 seconds at 09:22

Someone is confident? Or playing games? Or has a leaky feeling...?

I had to tap my pc monitor to check if the price was right ;)

Stach, if I see the typo "word class institutions" once more in a VAL RNS.... !

I can quote at least one PSA level drop, one of the 4mg patients dropped from ~500 down to ~250 over a period of 2 months, this was the slide included in the presentation 2 months ago. Otherwise VAL typically quote in % drop of late (was it 40-50+% drop typical when dosed at 4mg or above?).

Agreed a bit more transparency on these numbers would be desirable. I guess that's what they were trying to do with that stats review a few RNS back, but again no specifics.

Stach, some good points there, however in a dose esclation stage (tightly controlled 3+3 regulated increasing of dosing), I do not think a multi-centre would have sped things up so greatly. I think the earlier doses delayed us a bit, but that would be largely controlled by ethics and the regulators.

Now the next stage of the trial...wholeheartedly yes, multi-centre is the way to go if that badboy works properly.

Nice to get some new patent coverage, we are an IP company so any addition to that is welcome, I am not clear how large the Russia/Chinese endo market is.

Good to see that division trundling along, although I would like to see the 401 project converting into cash to pay for the 101 and 301 trials (and my pension, mmhmm, maybe).

The last report from UCLH was 17th October 2018 and I believe UCLH report every 3 months, I wonder if there's a update scheduled in the next fortnight. If I recall correctly that's the first patients dosed with 8mg (maybe 16mg now) on a twice weekly basis (I could be wrong) for about 3.5 to 4 months.

We want news :)

Congratulations to the University of California and Harvard Medical school for winning the CRUK Grand Challenge cancer sponsor project. I am somewhat bemused that CR UK seem to have opted for an entirely US researched project.

Well we'll need a bit of news and a poster or something to drive the SP, my gut feeling is that VAL401 is 4+ weeks away, could do with a general quarterly update.

Are you talking about the metastatic growth animal models? From what I recall there were 10x VAL201-treated animals (mice?) compared with 10x control group, half the number of VAL201-treated animals developed metastatic growths compared to control.

It's a slightly unusual comparison, so they'll have to validate that over a significant time period before they can claim that in humans, but when looking at the theory it makes sense (it could be clouded by the metastatic growth being smaller and less detectable, yet still present).

Yeah I remember that Scoobs, I just cannot connect how PSA doubling is calculated between a 50% drop and "-97.5 months" doubling time

Out of interest, for the patient on the 4mg cohort who had a pre-test PSA doubling time of 2.9 months, with a VAL201 treated doubling time changing to -97.5 months, does anyone here have any experience to indicate what the devil a negative monthly figure means?

Should I extrapolate a ratio? i.e. did the the PSA drop 34x?

I hear of patients at the high end having PSA levels in the region of perhaps 1000ng/mL, while "typical" levels of healthy patients are around 2ng/ml.

The patient had advanced localised prostate cancer and was deemed to be "hormone sensitive", so perhaps they are the ideal patient category.

Yes, I'm not fully researched on exactly how PSA correlates to tumour reduction, but it seems relatively simple. Prostate tissue releases glycoproteins, a bigger mass of tissue releases more glycoproteins, so a simplistic view is that reduced PSA levels are a very good indicator, albeit that cancers do not always follow the "intended path".

I would love to get a case study that said "This is Jim, he is 80yrs old and dying of metastatic prostate cancer. He was given VAL201 twice weekly for 4 months and the tumour shrunk by 70%, the metastatic growths disappeared completely, there is no sign of relapse. He has taken up hiking." but alas I do not think is a common report for a myriad of ethical/data protection/scientific reasons.

This was 2.5 years ago, so we now have several months data at 8mg, potentially some at 16mg more frequent injections.

https://www.researchgate.net/publication/313327620_A_first-in-human_FIH_phase_III_dose_escalation_pharmacokinetic_PK_study_to_assess_the_safety_and_tolerability_of_VAL-201_in_patients_with_advanced_prostate_cancer_APC_and_other_advanced_solid_tumours

Looking at the last few presentations, it appears GM is reporting 4mg dosing resulting in stable imaging with typical 30% PSA reduction, with 5mg showing similar 'stable disease', with Dr comments from the clinic "Anecdotally subjects showing stabilised and reduced PSA and other markets". Admittedly I would like to hear some numbers and case studies from the clinic on that, but I appreciate why they have to be a bit cautious with early stage reporting.

If GM can demonstrate >50% reduction with safety, imaging and patient outcomes backing that up, give the man a knighthood and let us all retire early ;)

Fair enough

Rio is the only major mining company within the EBA is it not?

*blessed autocorrect, last post all supposed to be about val101.

Val201 is an unusual treatment, bordering on genetic engineering and an unusual regulatory environment, it has rightly taken some time. Would love to see 101 in action on bcl2 cancers. Christ knows why 101 mk1 wasn't commercially manufacturable but I'll take George's word for it, fingers crossed on mk2 compound, was it early 2020 for val101 trial?

PS how easy is it for an ASX co. to move fully to London/Frankfurt? I assume my London shares would stay as they are (depending on how any deal was structured).

Theoretically of course, as this seems very early days in this bartering.

2 auctions held, price comes out higher afterwards, good sign of background selling, worth an educated trading investment?

Annoyingly my pot is not large at the moment, small topup added, curious how this will play out, it is clearly not the last we shall hear on the subject.

Is it in auction up, or auction down? Auction has been triggered