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Great post from JHFH - esp for us newbies

Technically they are clinical as soon as FDA approve clinical trials, not expecting it to be like flick of a switch and we gap up to 9p(100m) but you can be sure when the FDA does lift the hold there will be a series of updates, each attracting attention and flurry of interest. Lifting of CH is important, probably just as important will be the funding arrangement for CAR-T trials, a public placing in February is possible but unless the SP is significantly higher will not be useful, more than likely prevail will make a further strategic investment, hopefully 6p+ again which will really set the cat amongst the pigeons. Then with prevail making updates on the clinical trials etc I would expect us to get up to that 100m+ ball park pretty quickly.

Hemo 3.0 :) Lovely to see.

Good point Pumpky - FDA didn't take whole 30 days even with the full submission and this time, only one identified, solution agreed issue to resolve :) Could be any day, any time.

Many thanks all 🙏 Exciting times indeed.

JHFH - “IMO 100-300m mcap once clinical”. Does Hemo go clinical as soon as the CH is lifted? And, sorry, what would the sp have to get to for the mcap to be around 100m?

Highest sp since Jan 2023?

Thinking about it, the chances of an rns at any other time than 7am, must surely be around 50/50 - unless the FDA purposely inform after 4.30. Early starts and tenterhooks all days then!

Along with Hedgehogarth:) Some weight there!

Can't imagine a single LTH on here would mind if you do JHFH :)

FDA bingo administration question JHFH :)

If an rns of CH lifting comes at any other time tomorrow, not the usual 7am, does that still count as your call? Because - more seriously - when would the notification have to come to Hemo for it to be able to be in an 7am rns or would the FDA considerately inform Vlad before 7am?

As I said mid-afternoon, many thanks to those who've bothered to write interesting and informative posts today - that seems a while ago now. Surely an exciting week ahead: we can't all be right in JHFH's FDA bingo but anyone being right will do!

A very interesting, informative and clarifying day's postings on here today, thanks to all. Strange (and pleasing) to think we may be just ten/s of hours away from the rns which Vlad, Hemo and many wise lths here have been working towards for so long.

Sorry for so much posting this morning :{ I know CAR-T is a treatment but Is CBR potentially an antidote/cure/treatment or what exactly?

It does indeed Haywain, many thanks. Particularly with CBR in the background, it's going to be very interesting to see how long it is before CAR-T is attracting offers.

Bit confused about phase 1/2a. If/when Hemo goes clinical, are you suggesting Haywain, that the first trial could be a trial of 10-20 patients (phase 2?) and completed within a year? Or would that be after the successful trial of one patient? Sorry streaming cold-fog.

Happy to be revised HH especially as you let me keep the Microsoft dream :)

Much more seriously, if CBR were to fulfil its mind-boggling potential, have to be concerned about whether the human race is capable of enabling worthwile lives for all those who are saved.

Many thanks again, John - I hold with renewed confidence and interesting to see if Mr Nesis mentions penalties or negotiations on the 31st.

Thanks JHFH. So the strategy is most likely to be to get CAR-T into trials and then, guided by Prevail (experts in the field) to find the best buyer to licence the treatment to, in order to provide adequate funding to take CBR forward. And figures like £50/60m seem to be achievable for this.

Then on to CBR which as far as I understand it, isn't a single treatment (like a Land Rover 90 chassis) but a multi-use platform (like Volvo's base shared across their whole range) upon which can be built the antidote/cure/treatment (?) for many viruses and even some cancers: incredible.

But if the licence for CAR-T which is a treatment solely for one relatively small set of patients, could be worth £50/60m to Hemo, how could you possibly predict the value of EACH individual licence for EACH worldwide deadly virus potentially infecting millions of people? Microsoft indeed.

And we are shareholders in the company which might have such a life-changing impact on the world. We few, we happy few.

Hadn't thought there could even be more, Hulver! Hemo-fountain indeed then, with CAR-T the fundamental and vital pump-priming mechanism. That must be one set of very excited facilities :)

Thank you HH. Sorry if I was over-positive with that percentage, I tried looking through your past posts but don't know how to just see your Hemo posts.

Thanks too for the reality check on phase one duration: I wasn't thinking but of course it has to be that sort of time to see a treatment's effects on a living patient.