RE: Morning TF15 Apr 2021 07:58
Key bit
Key bit
Antibody responses are important against infection and reinfection, said Moss, “but the cellular response is more subtle”. T-cells might protect against severity of disease, but they may also be less susceptible than antibodies to loss of immunity from variants.
“I think people are confident that variants will only lose 10% to 20% of the cellular response, whereas they can lose a lot more of the antibody response. It’s about how the immune system works,” he said.
Plus this is only measuring the S protein response so think about SN 15 targeting S and N protein and what cell mediated effect that will have and the N protein is much more conserved and less liable to mutate than the S protein