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That is the Point .,... you question it with positive motive, so select what you consider adds weight and just ignore the rest
now i do this with the other share all the time ........... direct comparisons between other results I can i prove from other research that the science is spot on ...
How you can do that with Val is beyond me ............ everything contradicts
2018 BIO International Convention
Dr Dilly attended the BIO International Convention in Boston during the week of 4 June 2018. Recognised as the largest partnering and exhibition event in the industry, BIO is an opportunity to access global biotech and pharma companies. Presenting the VAL401 project, Dr Dilly held meetings to progress commercial conversations further with current and future partners, as well as presenting the project to new audiences.
june 2018 .......... the Glory Days
Dr Suzy Dilly, CEO of ValiSeek, commented: "The external validation from both the Advisory Board and wider industry, has provided increased confidence that VAL401, the product, has a valued and needed place in the market. These developments are a valuable addition to our licensing package, clarifying the final stages of clinical testing towards commercial use."
I did not know Burble had left ......... i am sure he did not either , he is not a prolific poster like you Knowlesi ... maybe he is just busy
anyway well done on Games workshop and all the others you have done well in ..... sorry about the Pram Business ...
The coronaviral genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein, all of which are required to produce a structurally complete viral particle [29, 37, 38]. More recently, however, it has become clear that some CoVs do not require the full ensemble of structural proteins to form a complete, infectious virion, suggesting that some structural proteins might be dispensable or that these CoVs might encode additional proteins with overlapping compensatory functions [35, 37, 39,40,41,42]. Individually, each protein primarily plays a role in the structure of the virus particle, but they are also involved in other aspects of the replication cycle. The S protein mediates attachment of the virus to the host cell surface receptors and subsequent fusion between the viral and host cell membranes to facilitate viral entry into the host cell [42,43,44]. In some CoVs, the expression of S at the cell membrane can also mediate cell-cell fusion between infected and adjacent, uninfected cells. This formation of giant, multinucleated cells, or syncytia, has been proposed as a strategy to allow direct spreading of the virus between cells, subverting virus-neutralising antibodies [45,46,47].
Unlike the other major structural proteins, N is the only protein that functions primarily to bind to the CoV RNA genome, making up the nucleocapsid [48]. Although N is largely involved in processes relating to the viral genome, it is also involved in other aspects of the CoV replication cycle and the host cellular response to viral infection [49]. Interestingly, localisation of N to the endoplasmic reticulum (ER)-Golgi region has proposed a function for it in assembly and budding [50, 51]. However, transient expression of N was shown to substantially increase the production of virus-like particles (VLPs) in some CoVs, suggesting that it might not be required for envelope formation, but for complete virion formation instead [41, 42, 52, 53].
https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0
"""" This formation of giant, multinucleated cells, or syncytia, has been proposed as a strategy to allow direct spreading of the virus between cells, subverting virus-neutralising antibodies [45,46,47]."""
Knowlesi ... let me explain .. its about the number you hold ..
so if you invested £100,000 in Games workshop .... x 300% .... = shed loads ... then why fuss about a 1p at 4p in scancell ?
however if you had of invested £1000 x 300% ............. you might consider that 1p more important
wait and see........ Covidity goes after the nucleus of the Virus as well as the spike ... which means its unaffected by any mutations of the Virus and should be good for at least 6 years cover
covid hides itself .... inside the cells of the lung away from neutralizing antibodies
only T cells can look inside infected cells . and kill them
that is what we are experts in ......... T cells that can take on the hardest targets .. cancer
just a tweak ...
absolutely NOT .......... why ...
No in house capability at all
CEO unproven ... indeed developed 401
Wants everything spun off in other vehicles which means you have no control over dilution or funding within them
Indicated the trial was halted for a "defined reason" .......... no explanation
All the data has been available to big pharma for at least 2 years including Val employing a dedicated liaison ? result ?
Requires at least another £5m invested to obtain the data of interest
why such a delay in the trial results when the majority already published .. so evidence only of the 8mg required or 4 patients .. not exactly rocket science
why no data on the approved 16mg
Not prepared to fund from the market
Totally reliant on a single product
thats to date ...
In Scancell over the years .... continued to buy ............... and like me rapidly increase there holdings sub 10p ...
Nobody has the right to say that was wrong or correct because Hindsight is a wonderful thing .. but i always pointed out the risk of failure is impossible because we have the crucial data on SCIB1 ................ in black and white
hence "no risk here"
results from that got us SCIB2 funded
it got us £2.7m for the consortium for Covidity ....
so that one bit of "good news" ............. is now generating interest
its also giving you the Combination Trial ............ full backed by Redmile ... why ? because they can read all about Synergy and the way it interacts with vaccine and PD-1 .......
yet the market still has not valued us correctly .............