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When you put it like that mact4…all very good points….The videos with mario (Kansas hospital) stating about phase 2 complete phase 3 move. Corrected first time but second time no correction and again synairgen stayed quiet…the recruit(replacement) clicincal research job.

Yep was spoke about in week and keeping an eye out. To have a specific protocol mention is telling imo and we know there are only 4 (the 3 mentioned) and bri that are still “open”.

I know a lot of this is clickbait but still interesting obviously as synairgen is mentioned but really the anticipated market size of just covid therapeutics reaching 25bn https://www.medgadget.com/2021/08/the-covid-19-therapeutics-market-to-record-an-exponential-growth-during-the-period-of-2021-2030.html

Indeed could be looked at if confirmed as we think on phase 3 and good interim read outs. The more exposure and evidence pointing towards interferon response the more attention synairgen will be getting globally and interest from relevant parties.

All it could take is one country saying yes let’s give exceptional eua for synairgen and away it goes.

Evidence is stacked up. Given the change of protocol on activ2 with more severe and breathlessness it feels like it is match made in heaven mind the cliche for synairgen on the trial. Bank holiday Monday. Hoping for an update Tuesday but in a way hope there isn’t as I will gladly take more at these levels as money is cleared.

SARS-CoV-2 suppresses IFNß production.... but does not suppress the effects of added interferon

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009800

Nevertheless, this virus remains sensitive to the effects of added interferon, providing an opportunity to treat COVID19 patients with IFN-Is therapeutically.

If you see the actual stats of vaccinated in US it’s something like 61% one dose and 51% double vaccinated. At the rate they are going to reach the fabled 70% herd immunity it’s estimate at feb 2022. You can now see why there is so much focus on therapeutics/treatments. Huge market just in the US.

It was up the nose and only in hamsters mind, Eric Topol and US doctors/scientists have been the ones studying interferon and referencing it a lot of late.

Matterhorn - Been scratching my head a bit more about the new clinical trialist joining, wondered whether there may finally be some movement with a phase 2 trial for this https://www.synairgen.com/programmes/loxl2-inhibitors-in-fibrotic-disease/

Was looking at pharmaxis quarterly report ending July and noticed a larger section/mention than previously https://www.pharmaxis.com.au/investor-centre/quarterly-updates/

Its interesting as it opposite where synairgen has excelled - in later stage

https://envt.fr/actualites/covid-19-etude-de-linteret-dun-traitement-par-interferon-intranasal/

Interesting - Researchers from IHAP (ENVT- INRAE ) carried out a preclinical study, in partnership with ANSES and Public Health England , to investigate the benefits of intranasal treatment with interferon. The results of this study show that the latter makes it possible to limit the clinical signs of the disease if it is administered early

So interferon is on public health England radar...interesting to suggesting early administration of interferon.

Anyone been keeping an eye out here.... https://www.riseabovecovid.org/us/en/treatment-summary

Look at the three remaining in enrolment Bri which we know about and then the other 3 being...."In Phase III, meeting the protocol definition of being at "higher" risk of progression to hospitalization or death (SNG001, SAB-185, BMS 986414+BMS 986413)"In Phase III, meeting the protocol definition of being at "higher" risk of progression to hospitalization or death (SNG001, SAB-185, BMS 986414+BMS 986413)

https://www.youtube.com/watch?v=9OZZ6_M4OB0
Over 1m followers in the US just released today, great video today explaining the innate immune system and Importance of interferon to protect against severe covid (why children fight off covid better than the old)

https://twitter.com/gggg2120/status/1430783186385178628

But we have vaccines……we are in summer….this is exactly why therapeutics needed, activ2 pushing on and so key. The protocol phase 3 with synairgen mentioned “higher risk of hospital or death”. Two major market pre hospital and as per below in hospital. No shortage of trial volunteers or recruits is there….. https://www.google.co.uk/amp/s/www.forbes.com/sites/nicholasreimann/2021/08/25/us-covid-hospitalizations-jump-above-100000-for-first-time-since-january/amp/

then straight away another 26k and 32k at days high....looks like fill or kill orders. Someone wanted in as these were O trades rather than algo bot.

Seems they didn’t take long at all analysing results

https://www.bbc.co.uk/news/health-58322882

Given this morning news i think its obvious even with vaccines, what we need is treatments/therapeutics which work. So really you need to do data set across vaccinated, half vaccinated, unvaccinated, 6 months after vaccine etc....

https://twitter.com/BM1kkel/status/1428355749126701067

In there, if you click on facebook from embedded link if i remember you get to see their page and uploads

https://www.prnewswire.com/news-releases/brii-biosciences-announces-positive-data-from-the-phase-3-activ-2-trial-evaluating-combination-brii-196-and-brii-198-in-non-hospitalized-covid-19-patients-301362210.html

Interesting this announced last night interim analysis on activ-2.......

Doesn’t our friend mario usually do the covid Kansas briefing on Wednesdays? It’s around 1pm U.K. time isn’t it?