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Early therapeutic, and even prophylactic, IFN interventions during COVID-19 could reduce disease severity and contribute to viral clearance, in turn avoiding multi-organ damage and patient death. IFN therapeutic administration during SARS-CoV-2 infection not only accounts for the antiviral and immunomodulatory effects of this drug, but it is also an opportunity to restore the SARS-CoV-2-impaired IFN signaling system, and thereby to promote the occurrence of other ISGs-mediated mechanisms that are relevant in the context of COVID-19. It also means that the antiviral and immunomodulatory effects of IFNs synchronized with other IFNs’s benefits for the direct or indirect control of inflammatory cytokines, neutrophilia, regulatory T cells, and the induction of ACE2 expression, may help to mimic a physiological antiviral response, with an intact IFN signaling system.

https://www.frontiersin.org/articles/10.3389/fimmu.2021.655528/full

Found it here it is

https://twitter.com/GGN94447444/status/1375429164291985412 Matterhorn - I am looking for the actual document but remember our conversation about prophylactic use - looks like interferon type 1 has been thought of being used in this case. Still trying to find out details on the care hime.

Probitatis what covid cases? https://ourworldindata.org/explorers/coronavirus-data-explorer?zoomToSelection=true&pickerSort=asc&pickerMetric=location&hideControls=true&Metric=Confirmed+cases&Interval=New+per+day&Relative+to+Population=false&Align+outbreaks=false&country=~OWID_WRL

No idea why we have had such a sharp daily rise. We are all basically locked up at the moment like in UK for 3 months nearly, cases will go down even more once people are unlocked.

Vaccine uptake worlwide is estimated at best around 70% due to the number of people who will not or can not take it, so yeh forget those other 30% 2billion people worldwide who would not be vaccinated. Worldwide vaccination going at a speed of knots currently 6% of world vaccinated, what happens when the next vaccines are needed in october yet people still haven't had their 1st vaccine, and then another top up and so on. No need for therapeutics at all. Not like there will ever be another respiratory pandemic ever again.

https://www.europeanpharmaceuticalreview.com/news/148536/novel-oral-antiviral-for-sars-cov-2-progresses-in-phase-i-trial/

How stupid must pfizer be, i mean they even have a vaccine yet they are still looking for treatments for covid at this stage. WTF do they know

Alinz there are more shares in issue now, focus on mcap.... the share is moved by funds not small time PIs with a few k. I guess they will struggle to recruit in Belgium for instance when 4% of the population have been properly vaccinated. Good job dorset trust already had 13 people signed up on trial 2 weeks ago. Good job SNG is phase 3 trial eh, no idea why pfzier is still working on therapeutics and brining them out for phase 1 trial like their news yesterday, they are not needed because of vaccines.

Sharks out i see

Merkel says we are in a new pandemic with the new strains coming, papers this morning saying new jabs need to be given in October, never been more of an urgent need for safe theraputics, know of any?

Weekly update calls are done mid morning in states on friday fyi, see if we hear any snippets i guess late afternoon or evening.

https://ourworldindata.org/explorers/coronavirus-data-explorer?zoomToSelection=true&pickerSort=asc&pickerMetric=location&hideControls=true&Metric=Confirmed+cases&Interval=New+per+day&Relative+to+Population=false&Align+outbreaks=false&country=~OWID_WRL

Some leap in covid cases again, just as US and UK are unlocking. Mid/End of april i reckon daily record will be hit of record covid cases.

https://mobile.twitter.com/Rengel25504081/status/1375333973522587649

Interesting.

Not yet no. Just been making friends with a few American physicians, will report back when I get more details.

Did anyone know here that there are weekly ACTIV-2 Investigator Zoom meeting where updates are being shared?

Closed 163, some move and expected, why would you sell at lowest price for over month on an overall red day across the market mad. Anyway, watching this was interesting Long covid really is an issue, can see now why the long covid trial really could be something special all together in its own right considering 70% figure. https://www.itv.com/news/2021-03-24/long-covid-70-of-patients-still-suffering-five-months-after-leaving-hospital-study-reveals

I started googling a few centres, many are actively recruiting for covid trails, they just don't say the individual names. For 200 recruits we only need say 20 centres recruiting 10 people, or even better 30 centres recruiting 6/7 people in the grand schemes of things that really is not a lot. As i said as of monday we will be at least 47 days into the US activ-2 trial.

Just as a posted and then checked back there had been a further update with more locations added, talk about timing, looks like as Richard said the US really want to get on with this. https://clinicaltrials.gov/ct2/history/NCT04518410?A=52&B=55&C=merged#StudyPageTop

Whole market down today red everywhere, today is a day to pick up cheap shares across the board, will be blue tomorrow across the market.

Hard to find exact sites but looking at this a number of sites for overall avtiv-2 have been added https://clinicaltrials.gov/ct2/history/NCT04518410?A=52&B=53&C=merged#StudyPageTop

The last time we dropped to these prices was thursday 24th Feb....friday 25th feb it closed at 174

Nice find, all moving at pace and did you see this? https://twitter.com/hub247/status/1375078954420289539