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There's no way we're going to get a negative announcement from the readout when it's announced tomorrow or whenever.

What we're going to get is an announcement that will be shades of grey and it will be from very light grey to dark grey. Some kind of success is already built in given the 14 + years that this has been monitored and tested, the nebuilzer improved etc, even if some of that reported success was anecdotal.

Don't lose sight of the non-hospitalised trial under activ-2 which was moved to Stage III in the U.S. because those running it were able to see the results (unlike anyone else including SNG) . Other similar trials they rejected at Stage II. So, to my mind this is shade, light grey and which I'm calling 20% effective.

The Frenchman Dr Aurélien Mary, Clinical Pharmacist at Amiens, is running his own nebulized Interferon Beta 1b trial at Amiens - goodness knows what the outcome will be as far as whether it infringes SNG's patent - but leaving that aside for now, his trial is only phase II with 146 patients and due to get results March 2022, so we're well ahead of the game. But he has been positive right from the beginning of this pandemic, enthusiastically extolling the virtues of interferon beta 1b and contriving his own nebulizer.
Here is the trial link:
https://clinicaltrials.gov/ct2/show/NCT04469491
So, with this independent third-party researcher working down the same path as SNG, albeit later in the process, I give that medium grey and in my simplistic terms warrants a success rate of 30%.

So, in my simple understanding of the history of SNG, when they announce the trial results, they are going to be successful ! Because, as we have seen from other trials, even 20% will give us success and therefore at the very least, will protect the current share price, but more likely to be the start of a consistent rise - again that's even with just 20% trial results. It is obvious to me that with just these few historical facts, a minimal success rate, good enough to support the shareprice is built-in.

I'm not a gambler - so have only put up money I can afford to lose - even so it is a very substantial sum for an ordinary individual that is now riding on the forthcoming announcement. It is far more than I have ever done in 40 years of share trading and it is because of the most unusual and possibly unique circumstances that I have outlined above that have moulded my opinions. I doubt that I will ever get into a share like SNG and at this financial level ever again.

I'm looking forward to the announcement when it comes and remaining very confident - perhaps my comments will give others some confidence too. Good luck all long term holders.

Aurélien Mary is actually a Clinical Pharmacist not a Doctor but I say that not to minimize any of his tweets. To my mind he has more knowledge because of that job. His percentage markers - even as low as 20% benefit over placebo - offer us every incentive to now stay the course to the end results. We never heard how he was getting on with a nebulized trial he was putting together in France using Interferon Beta 1a - was it at Rouen or Amiens ?

Either way it gives me confidence that in France they're watching and waiting too.

gggg21 - thanks for your excellent observation re Ashfield Engage. I hadn't picked up that the news was spreading within their organisation and can readily see how good this tie-up will be once phase III results are announced as proven.

Topupme - glad you mentioned about r/synairgen - although I thought I was in right from the start of the reddit page, I've never seen any Chat so I guess I was excluded :-(

Thanks Forest4032 - short and sweet when he talks of VOG

Testing the 6.5p level he says - I say, yes please, that'l be a start.

So guys - have enjoyed reading all your thoughts today but as a LTH also, I'm not used to seeing a VOG rise - do we have any facts or rumours as to why ?

Saxondale - thanks for the reminder to re-visit this video. It shows a very open and sincere RM explaining his take on the need for many treatments, vaccines and therapies going forward. Also, Synairgen's appreciation of the substantial US funding that they have received.

gunto2020 - apologies for calling £75 nonsense.

On the basis of the esteemed members of this BB today, I concur with the revaluation. I'll not accept anything less (well I may break ranks at £50).

Gunto2020 - of course it's a nonsense - that's why Takeovers happen because companies (and individuals for that matter) closer to the event, do buy-outs because they can see the benefits that will accrue further down the line. My shares are up for grabs for a lot less than £75 !

Good points llywelyn.

Looking on TrustPilot just now there are already 30+ reviews posted in under 24 hours so business still very good as usual for MHC.

There have though been half a dozen negative reviews all caused by Postal problems, whereby Royal Mail wasn't delivering because of the Christmas and New Year holidays. MHC made this clear on their website but I think travellers lose their common sense - but you can't help feel sorry for them having to follow a system that itself lacks common sense.

With all due respect guys, this is a BB on MHC - yes I get it - the Company does Covid testing but to argue about the Government and/or rubbishing the politicians isn't good for one's karma.

Let's see how the Management team of MHC respond to the problems and use the funds to grow the business and grow the shareprice - don't you think ? After all, it was only today that we learned of the deepening ties with Lloyds Pharmacy.

Very good thoughts this morning from you all - you help me to understand better some of the investment risks and more to the point the potential here. As we know, they are still a small, tightly run ship but look at where they have got to in such a short time.

I don't think we can expect an immediate uplift in the sp on this news but it makes me more excited to be once again holding a good stake in this fast evolving business. Very happy to be patient and for me at any rate, leave well alone and review my holding in the Summer.

GLA

Although having been an SNG shareholder for 7 years, I have never really had a good handle on the science. But I finally convinced myself at least not to worry, when the authorities running Activ2, who knew background results, moved it to stage III.

Unless they're going crazy, I can't see we SNG shareholders could expect a more positive interim marker than that.

AXE

Add me as well to the list please - just checked my contract notes and my first tranche of shares was bought 7 years ago. Thank goodness for this bulletin board as I might well have missed the boat and not added to my holdings.

Good luck all with your shares for 2022 and a Happy New Year.

jamrock
Interesting thoughts you've expressed - a holding of 6 million shares can be thought risky - not so much because of the merits or demerits of MHC - but because you'll be hard pushed to liquidate such a large holding and more likely you'll have to sell on good news, which is often when as a long term holder you'd rather stay in.

We've seen persistent chunky selling over recent weeks which is why the sp continues to languish, albeit it's off the floor now. I still believe it's from one source, or possibly from a similar stable. Don't forget it's less than a year since the 1.75p placing that none of us were invited in to and there were several undeclared institutions that bought in for the bulk of the shares beyond Mercia - yes there were better profits to be had in June but a profit within the year is still a profit for them.

I like to spread my investments - but each to his own - good luck with your holding and good fortune to all who sail in the merry ship of MHC.

HNY

I'm hoping for some positive news from WBI soon and with the market quiet took a look today at the price. Found that this afternoon (30th) could both BUY and SELL at the same price: 4.37p

Never sure what to think in these odd scenarios other than share liquidity must be good - which in itself is a good thing. So decided to top-up a little more today. GLA

Sorry Jamrock to read that you and your family have suffered from Covid these past few days.
I hope you are able to shrug it off quickly and that there are no lasting complications. All the best to you.

Cashola - with all due respect to you, there's no point now discussing what MED3000 is or is not (unless your LB's brother !). It is now an approved product for the EU & UK - we're just waiting for the Board to get it to market. I think we're suspecting, or at least I am, that the Board would like to delay this until the FDA have crossed the t's and dotted the i's but that's effectively a minimum of 6 months.

I'm hopeful that the two new Non-Exec Directors will gee Barder into action - I'm sure there's likely to be a Directors meeting early January and perhaps we'll get some action sooner rather than later.

Now this is interesting and something we haven't seen in a long time:

Today, Thursday 23rd there were two very large BUYS around midday 2 x 875,000 shares at 1.375p - a spend of £24,000

I admit to being surprised by today's strong finish. I feel the share had been oversold prior to the recent RNS, but even so, I am very glad to see a stronger finish for the day.

I was doubtful the sp would move up on this week's RNS but so far it is slowly edging upwards.