George Frangeskides, Exec-Chair at Alba Mineral Resources, discusses grades at the Clogau Gold Mine. Watch the full video here.

Less Ads, More Data, More Tools Register for FREE

Pin to quick picksTILS.L Share News (TILS)

  • There is currently no data for TILS

Watchlists are a member only feature

Login to your account

Alerts are a premium feature

Login to your account

Most Patients Stick With Milciclib In Tiziana Life Sciences Study

Wed, 24th Apr 2019 12:20

LONDON (Alliance News) - Tiziana Life Sciences PLC on Wednesday reported encouraging interim data from its trial of milciclib in patients with advanced liver cancer.

Shares in Tiziana were up 6.8% at 55.00 pence in early afternoon trade in London.

Biotechnology firm Tizania, which specialises in inflammation and oncology, said 80% of patients who completed treatment within the timeframe of the phase 2a trial have requested continuation of the treatment under compassionate use.

An interim safety review of the trial also found that the drug "was not associated with unexpected signs or signals of toxicity" when administered to patients with advanced hepatocellular carcinoma - a type of liver cancer and the fifth most common cancer worldwide.

Milciclib was administered repeatedly during the six-month study period to ten patients, eight of which wanted to continue treatment while seven were approved to do so under compassionate use. Three of the patients under compassionate use have completed 9, 13, and 16 months of treatment with the drug while four are continuing with the drug.

No drug-related deaths have so far occurred and the drug is well tolerated.

"Demonstration of safety and clinical activity is important milestone to move forward with strategic options for further clinical development of milciclib either as a single agent or in combination with one of the [US Food & Drug Administration] approved drugs for treatment of [hepatocellular carcinoma] patients," said Tiziana Chief Executive & Chief Scientific Officer Kunwar Shailubhai.

"We previously reported data from preclinical studies demonstrating that milciclib produced pronounced synergistic anti-[hepatocellular carcinoma] activity in combination with any one of the FDA approved drugs such as sorafenib, regorafenib, and lenvatinib," Shailubhai added.

More News
20 Oct 2021 15:04

DIRECTOR DEALINGS: Strix team bank GBP6 million; Kingfisher bosses buy

DIRECTOR DEALINGS: Strix team bank GBP6 million; Kingfisher bosses buy

Read more
7 Oct 2021 06:07

DIRECTOR DEALINGS: Quartix CTO Seffino sells; Tiziana chair buys stock

DIRECTOR DEALINGS: Quartix CTO Seffino sells; Tiziana chair buys stock

Read more
5 Oct 2021 14:41

DIRECTOR DEALINGS: ScaleUp cuts Kooth stake to 37%; Hiscox CEO buys

DIRECTOR DEALINGS: ScaleUp cuts Kooth stake to 37%; Hiscox CEO buys

Read more
28 Sep 2021 14:26

DIRECTOR DEALINGS: Everyman Media CEO and Tiziana chair buy shares

DIRECTOR DEALINGS: Everyman Media CEO and Tiziana chair buy shares

Read more
24 Sep 2021 19:05

IN BRIEF: Tiziana Life Sciences loss widens but progresses pipeline

IN BRIEF: Tiziana Life Sciences loss widens but progresses pipeline

Read more
20 Sep 2021 16:05

UK shareholder meetings calendar - next 7 days

UK shareholder meetings calendar - next 7 days

Read more
2 Sep 2021 21:44

TRADING UPDATES: Challenger Energy hails Saffron-2 well; SDCL placing

TRADING UPDATES: Challenger Energy hails Saffron-2 well; SDCL placing

Read more
2 Sep 2021 10:55

SMALL-CAP WINNERS & LOSERS: EnQuest falls on production output warning

SMALL-CAP WINNERS & LOSERS: EnQuest falls on production output warning

Read more
20 Aug 2021 18:16

IN BRIEF: Tiziana Life Sciences commences corporate restructure plan

IN BRIEF: Tiziana Life Sciences commences corporate restructure plan

Read more
20 Aug 2021 11:13

AIM WINNERS & LOSERS: Tiziana plans switch to US; Vertu ups guidance

AIM WINNERS & LOSERS: Tiziana plans switch to US; Vertu ups guidance

Read more
17 Aug 2021 15:39

TRADING UPDATES: Chrysalis backs InfoSum; Argo Blockchain goes green

TRADING UPDATES: Chrysalis backs InfoSum; Argo Blockchain goes green

Read more
23 Jun 2021 17:25

TRADING UPDATES: Marlowe turns to loss; AFC Energy sees maiden revenue

TRADING UPDATES: Marlowe turns to loss; AFC Energy sees maiden revenue

Read more
18 Jun 2021 15:47

UK shareholder meetings calendar - next 7 days

UK shareholder meetings calendar - next 7 days

Read more
17 Jun 2021 17:42

EXECUTIVE CHANGES: LPA, Brewin Dolphin make new appointments to board

EXECUTIVE CHANGES: LPA, Brewin Dolphin make new appointments to board

Read more
25 May 2021 17:11

TRADING UPDATES: Mothercare sales down; Revolution Bars seeks to raise

TRADING UPDATES: Mothercare sales down; Revolution Bars seeks to raise

Read more

Login to your account

Don't have an account? Click here to register.

Quickpicks are a member only feature

Login to your account

Don't have an account? Click here to register.