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Pin to quick picksAstrazeneca Share News (AZN)

Share Price Information for Astrazeneca (AZN)

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Share Price: 7,852.00
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Change: 66.00 (0.85%)
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UPDATE 3-EU regulator backs J&J shot, finds possible link to clots

Tue, 20th Apr 2021 15:26

* EMA assessed 8 cases of serious clots in the United States

* Says overall benefits outweigh any risks

* Cases occurred in adults under 60, most of them women
(Adds details, quotes from EMA news conference)

By Pushkala Aripaka and Anthony Deutsch

April 20 (Reuters) - Europe's drug regulator has found a
possible link between Johnson & Johnson's COVID-19
vaccine and rare blood clotting issues in adults who received
doses in the United States, but backed its overall benefits
against any risks.

The European Medicines Agency (EMA) said on Tuesday its
safety committee had concluded that a warning about unusual
blood clots with low platelets must be added to the vaccine's
labels, just as it has also required of rival vaccine maker
AstraZeneca.

The review of the cases prompted a pause in the rollout of
the vaccine in Europe and the United States last week, the
latest blow to efforts to tackle the pandemic, which has killed
more than 3.1 million and infected 142.1 million worldwide.

Several nations have suspended or limited the use of
AstraZeneca's vaccine over possible blood clots. (https://bit.ly/3xckNFu)

The EMA examined eight cases of clotting that occurred in
U.S. adults under 60 years, mostly women, within three weeks of
vaccination with J&J's single shot.

The EMA's review has led to the conclusion that "these blood
clots and disorders are very rare side effects of the vaccine,"
Sabine Straus, chair of EMA's safety committee, said in a
briefing.

If treated early, health care professionals can help people
in their recovery and avoid further complications, she said.

EXTREMELY RARE CLOTTING

With both the AstraZeneca and J&J vaccines, the reports
involve extremely rare clotting, mainly a type of blood clot
called cerebral venous sinus thrombosis (CVST), that was seen in
combination with low levels of blood platelets, called
thrombocytopenia.

J&J has said it is working closely with regulators and noted
that no clear causal relationship had been established between
the clotting cases and its shot.

The EU watchdog also said that most clots had occurred in
the brain and abdomen, as was the case with AstraZeneca's
shot, Vaxzevria, which is also being studied for similar
blood clotting problems.

"One plausible explanation for the combination of blood
clots and low blood platelets is an immune response, leading to
a condition similar to one seen sometimes in patients treated
with heparin," the EMA said.

The U.S. health regulator last week recommended pausing the
use of the J&J single-dose shot after six women under the age of
50 developed blood clots after receiving it.

The cases were reported out of more than 7 million doses
administered in the United States as of April 13, the EMA said.

U.S. authorities will meet on Friday to discuss whether to
resume using the vaccine.

J&J, which recorded $100 million in COVID-19 vaccine sales,
has delayed rolling out the vaccine to Europe, but said on
Tuesday it was prepared to resume the deployment. It has said it
would aim to deliver 55 million doses to the EU, as contracted,
by the end of June.

J&J's vaccine, developed by its Janssen unit, is one of four
COVID-19 vaccines authorised for use in Europe.

(Writing by Josephine Mason
Editing by Gareth Jones)

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