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WedMe:
Thank you for all your work this weekend....a real tonic to read Sunday morning....well done....great !!!
GLA
Thank you WedMe! I think what we're starting to see with your post (and Monicello's yesterday) is the eventual publication of the science that a lot of us based our investment here on. Those initial (non-peer reviewed) reports that suggested interferon would be really effective against Covid led a lot of us to invest heavily in SNG before the 20th July. Yet as the official publications start to filter through, still there is no scientific argument against the use of this inhaled treatment, and there remains little else to combat the disease early.
It's only a short matter of time before we see approval for this and it's going to be incredibly valuable!
Two goods posts. Enjoyed reading.
Morning mate. I was wondering if there would be some of the usual suspects popping over whilst things are quiet 'elsewhere'. I am hoping success here will enable me to significantly increase my holdings over there. I have kept a decent amount as a backup in case this does not go according to plan. We find ourselves in the familiar position of waiting for something to blow. I am hoping we don't have to wait too long here but you and I both know you can't take anything for granted. Anyway, I hope you are keeping well.
Surely we must be due news tomorrow?
want instead of what
I think production has already started !! GLA !!!
Wedme
I was looking at other interferons as well and my postgraduate thesis involved the complement system involving C3d etc. I also believe SG001 is a low risk item in the clinical tool kit. Its safe to use from what I can see. If I had the authority to make an emergency decision, I would order a supply for the hospitals taking in the most elderly Covid-19 infected patients. I would leave the local doctors and the patients the choice of taking the risk of treatment upon what we know on no fault arrangements as we know what happens if we stay with practices of last spring so that everyone was aware of risks. If we see those hospitals coping and discharging patients in a way similar to influenza outbreaks it could then be made more available within say weeks across the service. Any adverse responses could be recorded carefully, I believe there is a Department in Liverpool to deal with those aspects. It would allow the government other policies to work. The UK would be the show case for other countries who may then what access to it.
Wedme
An excellent post that clearly explains why and how SG001 works, and why it will receive approval sooner rather than later, so that it can be utilised very quickly to save lives and reduce the otherwise severe effects that some people who are infected will suffer
Is this review part of the official peer review that RM referred to in July? If not do we know when this will be released. Also when do most investors here think a reasonable deadline would be this year to start production to treat this pandemic worldwide. As surely if approved SNG would require far more than 1 supplier for inhaler & treatment
Part 2 of 2.
In the first study they also look at people with existing antibodies towards Covid-19 and state that:
"antibodies against COVID-19 might represent a double-edged sword; beneficial by neutralizing the virus and detrimental by contributing to over-activation of the complement system"
In other words according to their research - antibodies, from either a previous infection or a vaccine, over stimulate the complement system and can cause further damage in your lungs and body by causing a chronic over-activation of your immune system which completely negates the potective assumptions regarding antibodies and vaccines. Showing why people are getting infected again with some a lot worse the second time.
And why people are getting lung and organ damage months after infection.
https://www.nature.com/articles/d41586-020-02598-6
In conclusion they say:
"The anaphylatoxins C3a and C5a and the terminal complement complex C5b-9 are the most potent inducers of inflammation, and inhibition of these should thus be prioritized. Thus, therapeutic inhibition on the level of the common pathway including C3 or C5 inhibition seems most promising in light of the results from this study."
Inhaled interferon beta, SG001, would do just that by completely counteracting their suppression of the body's natural antiviral and anti-inflammatory interferon beta and shows why if SG001 is administered at an early stage of the disease causes such a remarkable reduction (79%) of Covid-19 virus' effect by greatly reducing the length of the disease in your system and in so the length of the damaging over-activation of your immune system.
In other words: SG001 = Win
Part 1 of 2.
I was studying some clinical studies this weekend and have found some very interesting things which independently verify SG001 as a main treatment of COVID-19. Most likely even over vaccines.
This peer reviewed study I found was published a few days ago, on the 17th, regarding the cause of respiratory failure in Covid-19 patients. In it they lay out which pathways cause an inflammatory reponse in the body leading to respiratory failure, ARDS, organ damage, and death.
It shows that a long and systemic activation of the 'complement system' - a key component of the immune system is the cause of serious respiratory and negative effects of Covid-19. The complement system, that consists of proteins that are produced by many cells and organs in our body that continually circulate in our blood and tissue, are our 'first defence' against virus and bacteria. But a chronic over-activation of this system, as seen in lupus, causes damage by attacking all your body's cells in an attempt to 'heal' you.
An over-activation of our own immune system caused by the virus is in other words what damages our organs and the cause of mortality.
https://www.pnas.org/content/early/2020/09/15/2010540117#xref-fn-3-1
The pro inflammatory complement anaphylatoxins C5a and C3a are the main culprits by producing an over-activated inflammatory response caused by Covid-19.
Now what is interesting is that those two anaphylatoxins suppress the body's natural production of none other than interferon beta.
Without the anti inflammatory and antiviral protection of interferon beta - which stops the virus from replicating - your body is unable to defend against the virus effects and your chronically over-activated immune system causes considerable damage to lungs and organs. This is why older people, who naturally already have a large reduction of interferon beta, are at greater risk of mortality and respiratory failure. And why bats who have a high level of interferon beta are unaffected by coronavirus.
(Here you see the suppression of interferon beta by C5a and C3a: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398560/ and the anti-inflammatory protection that interferon beta gives: https://www.ft.com/content/743ce7a0-60eb-482d-b1f4-d4de11182fa9 )
So if you get Covid-19 you immediately need more interferon beta to fight the suppression of interferon beta and to halt tissue damage. Inhaled SG001, which directly targets the lungs, is the most efficient interferon beta treatment with fewest side effects by far in any treatment I have studied.
End of part 1.