Gordon Stein, CFO of CleanTech Lithium, explains why CTL acquired the 23 Laguna Verde licenses. Watch the video here.
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Rich - As is so often the case on these boards the lack of body language, vocal tone etc means that text gets taken in many different contexts. I'm sure if this was a conversation happening face to face we would get less of the ramping, de-ramping suggestions.
The announcements released today have no bearing on the outcome of the trial apart from we will have to wait a little longer for news. Which as you say could go one way or another.
I see no negatives in todays announcement other than the delay. I see several positives regarding perceived safety of the drug and that the at home trial is now open for recruiting. But again neither of these will effect the outcome of the trial.
Ghia - the problem is you're reacting as if I've said this is going to fail or something. I said nothing of the sort. I simply said that you COULD easily infer from the current news that it might not be having blockbusting results. I didn't say that it definitely was or wasn't. I specifically said that because I knew people would overreact for no reason.
Ultimately this is a gamble on the success of a drug trial and reading the RNSs I personally wouldn't have got more confident. It doesn't mean I don't think there's any chance of success because clearly there still is (and everyone can make their own guess on that likelihood).
Woodstock - Aloha. What happened with old destitute? He was negative for so long I can't remember anymore if he bought in, in time for the big rise, or missed it.
notnow20, you seem to be having trouble distinguishing between yourself and Ghia. Are you the same person or just the same party line on everything? If you want me to believe you're just a long term holder here, who just happened to turn up along with everyone else when it hit the news, then you'll need to swap my brain out for Boris Johnson's defective one, as he's claiming to believe Cummings excuse about "testing his eyesight" (of course he's just lying).
This is all irrelevant anyway. Either SNG will succeed or it won't. Nothing you, I, or anyone else, says, will make any difference to that.
Rich - Then please enlighten me as to what you meant ref your comment below:
"As a now casual observer I think the SP simply reflects the fact you COULD (I'm not saying definitely) argue that today's news might indicate the treatment is perhaps not having a massive effect at the later stages of COVID (ie when people are in hospital). "
Seems to me you where implying you could second guess a double blind placebo trial?
I'm the first to admit I haven't been here as long as others bio tech was not my area of interest but it has got more relevant and interesting to me personally recently.
You have some fairly rampy posts yourself in your post history on here from periods when you where obviously invested I guess that sentiment doesn't suit your song sheet currently.
I'm not one for personal attacks i'll happily engage with you to debate facts and theories but lets leave the I've been here longer than you rhetoric to one side, it's meaningless.
RichTheNewbie. Hopefully Destitute will start posting again.
I was right on the Ftse and Dow forecasts.
Warm regards.
Ghia - that's a total load of rubbish. Stop changing what I said then criticising me for things I didn't say. Also, please stop pretending to be a long term holder. You've only been here since April! FYI - It's very easy for me to see all the charlatans because there were probably less than 5 people on this board who were posting in the past few years. I was one of them and you definitely weren't.
Rich. I remember that you were one of the original posters on here when the sp was 18p, 2 months ago. Does my memory serve me right ?.
Atb
Rich - I'm happy to engage with you in a sensible debate but your comments lack substance.
You are trying to suggest that you can second guess a double blind placebo trial that's nonsense.
You are trying to suggest that a significant number of trial patients are worsening, the global stats don't support this.
Post some facts rather than speculation and I will engage with you.
Here's a fact for you we now have approval to recruit High Risk 50+ year old patients outside of the hospital setting. That's a massive vote of confidence for the safety of the drug.
notnow - I can understand and do sympathise with the mindset of those selling, I can think of many scenarios why they may wish to, off of the news today. None of those reasons have any bearing on the outcome of results.
The share price will move up again when we see an influx of new buyers which will be delayed marginally by todays announcements but come mid June people will be taking their positions.
All of us LTH's here will just have to sit and wait some more there should be some good articles appearing this week to entertain us.
I can see the board is now full of useless ramping cretins who can't discuss anything sensibly and just dish out abuse to anyone not heavily promoting it. Tut tut.
Apologies all I've just read that again. No age limit on High risk individuals??? That's massive!
"The expanded trial includes patients who have had symptoms for less than 72 hours and are aged 50 or over with a high-risk comorbidity (such as cardiovascular disease, diabetes or a chronic lung condition), or aged 65 and over."
We must have safety nailed if we are allowed to dose high risk patients up to the age of 50.
The over 65 extension also allows us to access a subset of people in car homes.
This is really good news for those effected and us.
There's the presence of 24 respiratory pathogens as co-infections in COVID-19 patients. Most of these co-infections occurred 1–4 days after the onset of disease in COVID-19 patients.The proportion of viral co-infections, fungal co-infections and bacterial-fungal co-infections were the highest in severe COVID-19 cases.
Interferon is used for the treatment of these co-infections.
Rich - Jog on and troll somewhere else useless comments.
How do you define no one getting better? The mortality rate of the virus indicates that a significant number of the 98 on the trial will have survived. I hope for their sake all 98 did.
What the trial will show is if our drug helped speed up that recovery and reduce any lasting damage.
"trial is a randomised double-blind placebo-controlled trial. It is impossible for anyone to know the results at this stage including SNG"
That's not strictly true. You might not know the exact numbers, however if nobody was getting better, then it doesn't matter if it's blind or random, you know the result. Similarly, if a lot more people than usual are recovering, you would have a pretty good indication (not certainty) that it's working.
Rich - You cannot second guess a double blind trial.
At home Trial is not a reaction to perceived hospital trial performance it was the original intention of the company.
The hospital trials was a necessity for many regulatory reasons and was designed specifically to exclude those in the later stages of Covid infection.
The company knows their drug and have given it the best opportunity to produce pleasing data.
The stringent trial criteria is contributing to the relatively slow recruitment to the trial. It has got harder to fill with the reduction in infections and the number of other trials all competing for the same pool of patients.
I’d be concerned if I was invested in a share that started recruiting later than Synairgen they might not fill their trials.
Especially if at home prevents patients ever getting to the hospital setting.
As I said before moving to at home is in tune with where this crisis is now happening.
Notnow20,
I had hoped that we could have recruited many more than 120 patients for the home trial because SNG001 will have to show a big % over placebo in this patient population. 120 patients in total so 60-60
On active versus placebo ... Tight statistics
As a now casual observer I think the SP simply reflects the fact you COULD (I'm not saying definitely) argue that today's news might indicate the treatment is perhaps not having a massive effect at the later stages of COVID (ie when people are in hospital).
I believe that's not entirely surprising and I think I'm right in saying (from my memory of reading everything related to synairgen / interferon beta) that there's been a good chance that it would be better as a prophylactic (preventative) medicine rather than a later stage treatment.
So I wouldn't be surprised if the treatment had showed some effect in hospitals, but perhaps not a massive one, and therefore they're now testing on the other major way it might help (ie it might not be outstanding as a treatment for full-blown COVID but might help people with symptoms prevent it getting to a severe stage).
It has always been my opinion that Results could be different in hospital patients versus at home patients ....
Placebo levels will be different imo but not just that
Getting interferon into patients at the early stages should help the immune system to fight back more effectively straight away ....
If patients are unwell enough to be hospitalised then we might not have the same results ,as the dosing levels remain the same .
would they be expanding the hospital trials and now moving to homes if it was not showing positive signs?
Would not surprise me if now that it is hospital and home that we hear about Synairgen a lot more.