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Correection: not „in their lung“, I meant „in other lung disease“ and in principle in all immunonsupressed people.
If we get an effect here then this effect is most likely also present in their lung. I am thinking about cystic fibrosis. Lung fibrosis, lung (or other cancers) or also immunosupressed patients - no reason why this effect (of present) would not be there in many other situations. The data against Covid are really impressive. If shown also in COPD patients - then this has much more potential then I originally thought. Thanks again Christoffer and John !
Thanks a lot, Cheistoffer, and also John! I am very well aware about it’s antiviral effect by boosting various cellular defense mechanism and increase resistance of surround cells against infection. I actually did my doctor (veterinary medicine) in virology. I did not get that link between COPD and the antiviral effect. I was wondering how Interferon could act here. But now it is clear to me and this is a sound hypothesis. Yes, obviously Interferon Beta could make sense here and have an effect. I did not check the study design - it may be difficult to show such effect in a Phase II study due to the limited statistical power of such trial. But let‘s see. If it was well designed, maybe something will be found which may result to a confirmatory phase III study.
Hi Frank, from the RNS on 27th Sep 2019 (not sure if you've see this);
"Synairgen's two-part Phase II trial, called SG015, has been designed to assess Synairgen's inhaled IFN-beta in COPD patients when they have a cold or flu infection. The data being presented are from Part 1 of the study, in which patients were treated with inhaled IFN-beta when they did not have a cold or flu infection. Analysis of samples from the lung shows that treatment with IFN-beta boosted the lungs' antiviral defences, increasing Synairgen's confidence in the likelihood of a positive outcome in Part 2 of the study in which inhaled IFN-beta is being assessed when patients do have a confirmed respiratory virus infection."
This drug is an antiviral, which could be helpful to someone with COPD who gets flu. It could also be helpful to someone who is otherwise healthy that get the flu, or a novel coronavirus say.
Obviously - COPD has also huge potential. Here everybody is waiting for the study Phase II outcome. Can anybody here provide a link or source (peer-reviewed journal) about the proof of concept maybe from a phase I study or any other information from human data which indicate that Interferon Beta may work in COPD ? I am fully aware it is now up to the Phase II study to show some effect (any clinical relevant endpoint), but I am missing a bit the basis for that COPD optimism. Don‘t get me wrong, I have SNG (unfortunately only 2k), you may be well aware about existing human COPD data (if available). Or is this optimism entirely based on the mode of action of interferon b?
This is not just about Covid19, do some research rather than make yourself appear even more foolish .
d'Pansey,
"Covid stocks are dying"
Why are you on this board?
duanebansey its Friday so you have missed one off, wouldn't want to be out of this over the weekend.
must admit, things have heated up in that last 3 weeks it is great to watch.
Mr Big.....well I hate to break the news to you but :-).
I am happy with the progress and hope all of us in here whether it was from the low 30’s or new blood who have just come in are fruitful. Good luck to all of us! Home trials news and peer reviews news coming I’m excited.
Stay safe.
that's probably what those people say to their wives/girlfriends/boyfriends/other.
Top 2 most boring repetitive posts
1) wait till the USA market opens - this will go massive (never does)
2) BOOOOMMMM!
What's next TC, are you going to tell my weans that Santa doesn't exist?
All I can say is Cheer up!
The phrase ‘wait until the yanks wake up’ always amuses and in a way frustrates me when I see it. Some posters actually think US ii will be forced to wait until their exchange opens before they can buy stocks traded on the London exchanges. All I can say is wise up!
The Yanks are on it 24/7 like we are...
Haha -
Just you wait 'till the yanks wake up!
Why?
Is going to be crazy here.