We would love to hear your thoughts about our site and services, please take our survey here.
London South East prides itself on its community spirit, and in order to keep the chat section problem free, we ask all members to follow these simple rules. In these rules, we refer to ourselves as "we", "us", "our". The user of the website is referred to as "you" and "your".
By posting on our share chat boards you are agreeing to the following:
The IP address of all posts is recorded to aid in enforcing these conditions. As a user you agree to any information you have entered being stored in a database. You agree that we have the right to remove, edit, move or close any topic or board at any time should we see fit. You agree that we have the right to remove any post without notice. You agree that we have the right to suspend your account without notice.
Please note some users may not behave properly and may post content that is misleading, untrue or offensive.
It is not possible for us to fully monitor all content all of the time but where we have actually received notice of any content that is potentially misleading, untrue, offensive, unlawful, infringes third party rights or is potentially in breach of these terms and conditions, then we will review such content, decide whether to remove it from this website and act accordingly.
Premium Members are members that have a premium subscription with London South East. You can subscribe here.
London South East does not endorse such members, and posts should not be construed as advice and represent the opinions of the authors, not those of London South East Ltd, or its affiliates.
Thanks for that Red ,
That makes me feel more confident, obviously i have got that one wrong , i was getting paranoid thinking OMG are they trying to kill it.
Just to add to the response Bobby bingo...
As I posted the other day, if you look in detail at the results there were a proportionally higher group of patients in phase 4 versus the placebo group in the phase 2 trials which had the combination of OSCI 3/4.
So not only did we have amazing results it was actually against a sicker treatment group is how I read it. It certainly shouldn't therefore be a concern that the p3 is only focused around this OSCI category 4 group. If anything you could argue that it is more likely to emphasise the mortality and recovery benefits as if all things remain equal and tragically you would expect more negative outcomes in the placebo arm.
Boobybingo - Not correct Syn being trialled on Phase 4 Patients only (just prior to Oxygen and Ventilator Status as I understand) - and if you read RNS and Info accurately then it clearly states that last trial was on trialled on 3 and 4 stage patients - this time only stage 4 the more unhealthy will be trialled. However under previous trial the stage 3/4 stage patients showed nearly 80% improvement in recovery etc. So you 1 post deramp inaccurate communication needs amending buddy.
This is not a de ramp. I am heavily invested here, I am worried that as the medical consensus is that interferon is best given early and this phase 3 is only to be tried on people on oxygen, which is later stage and it clearly states in the phase 2 trial results that people at later stage on oxygen did improve faster 6 days instead of 9 but it did not reach statistical significance so that got me concerned, perhaps i have not understood the phase 2 results so if someone can check the phase 2 info that was released and i would be very happy if i have got this wrong ? ?
My feeling too B2HS2L.
Are there many UK manufacturers of Interferon Beta please?
Inhalation delivery trial of vaccines by Imperial and Oxford is an endorsement of SNG as a method of delivery worth investigating ( they know SNG method of delivery is a great opportunity to emulate ) imv
brrr - I think the trial would finish by default if the placebo patients are offered the drug.
You are trialling drug versus placebo, so the trial would end, everyone has been offered the drug, and any savings in time and money can be realised. Most of the money would be spent unfortunately by then in my view.
Thanks Matml74.
Brilliantly summed up.
Using INHALED form of delivery is what really sets SNG001 apart from the others.
Reading some worrying news from Belgium, the Wallonia region is up to virtual full capacity in their covid wards. Doctors are facing the stark choice of making triage decisions on who gets hospital beds or not. Only has a population of 11 million Belgium and they are getting 10,000 new cases a day now. The UK is two-three weeks behind Belgium in the cycle. It is going to be incredibly frustrating here if we do see the Nightingales filling up and the Gov proves to have done too little too late in supporting us and other viable therapeutics. Tell the hospitalised this winter their is a vaccine possibly coming in the Spring.
Agree Red. People also seem to forget the following.
It worked in the LAB
It worked in ASTHMA trial
It worked in COPD trial
It worked in COVID trial
It works.
Let all these shenanigans pass and Be patient.
apologies if already posted
Landmark coronavirus study to trial inhaled Imperial and Oxford vaccines
Everybody wants to use this delivery method
Hold for 7 figures!
Presumably we wouldn't need to get anywhere near our Phase 2 result targets either to be approved?
If we are heralding Dexamethasone for having a c25% improvement in outcomes then all we need is a statistical significance that SNG001 improved outcomes in probably about 35% of patients.
Obviously my numbers are finger in the air but i don't think we need to exactly replicate the 79-82% improvement in phase 2 to proceed although cost considerations mean it would probably have to be a bit higher than Dex as its so cheap.
And if its higher than 79-82% then i'm probably talking to a bunch of millionaires right now.
I asked one of my brothers this question last week, mainly regarding the Hippocratic Oath ethics during a Trial and the placebo group. He's a biochemist and worked for Oxford Uni, Boston Uni and Pfizer [all in Reasearch]. He said if the results started to show overwhelming signs that the medication was effective then the placebo half would also be offered it. He didn't mention if the trial would then be halted.
B2 - Lets wait and see.
GLA
Agreed CW
Stopping the trial for 'benefit' would only happen IMO if they had already made the decision that the drug should be licensed without caveat, else everyone would be in Limbo.
Having looked at the reference material, I think there is a very good chance ph3 will not complete, because 3 patients died taking placebo in ph2, and if more don't make it in phase 3, they will not waste more time.
B2 - my opinion is that if the results continue to be good as they are then why see out the rest of the trial? The drug would be meeting standards set out and I would imagine there are already talks in place to get the drug licenced.
Stopping the trial for benefit would mean (to me) that SNG001 has approval and can be rolled out to the masses.
Compared to other drug trials that can take years to get to phase 3 with countless other studies which run alongside them to provide enough evidence to obtain a licence, this trial has moved like lightening. Hats off to the team in Southampton, they are working tirelessly behind the scene's to not only save humanity, but keep shareholders happy.
CW, - Like you I don't think there is going to be a problem with ph3.
I'd like your feedback on why it might be possible that this ph3 won't complete.
"Stopping a Phase3 trial for 'Benefit'" - this bb - 19.10.2020 - 21:40
Why on earth do you think phase 3 is suddenly going to fail? Phase 1 & 2 were successful. Its the same drug just given on a larger scale.
Also stop panicking about no news. Since July we have massively progressed forwards with these trials, much quicker than normal drug trials. News will come, it will be good, they havent suddenly changed the drug from phase 1& 2.
GLA.
p.s if you have no patience, stop looking at these boards and get on with your life!!
Before you consider the risk of Phase 3 failure, can I suggest if you haven't already, then try reading the thread "Stopping a Phase3 trial for 'Benefit'" - this bb - 19.10.2020 - 21:40.
That might affect how you see risky this ph 3 trial is.
Yep agreed herbie
Well I'm balls deep. I'm either going be a millionaire thanks to RM and the team, or I'm going back work.
You got to be in it to win it!
This share is just one treatment and if phase 3 is a failure we will see at least 50% loss of money from our pockets. If it works then we will get few more millionaires but is it worth the risk? Science is strong, hopefully it is strong enough to deliver necessary results. I wouldn't put more than 20% of my money here. I was more confident in august but government and big pharmas failed to support this. It could be a good sign if synairgen is confident enough and refused to sell for cheap but who knows what really happened