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Nolupus,
Unless they are a distressed seller, in which case they are forced to sell and happiness doesn’t come into it as you well know. Link should be under pressure to sell here and as far as we know haven’t sold a single one. Maybe they are very happy:).
TRek ,
I should have explained more when I said that I prefer to see the Sp going down or staying put before news ...
I have often noticed that we have a spike in volumes and the SP before results which mostly is organised by the majors to allow the big boys to sell their stakes .
When we see the contrary it's the opposite ... it means the majors are happy to stay in ...
You are a Star Trek. :-)
Trek
Raising a glass to that last statement !
G
The three most frequent micro-organisms that co-infected Covid-19 patients have are :
Streptococcus pneumoniae, Klebsiella pneumoniae & Haemophilus influenzae.
Hi Nolupus,
Contrarian or not you sit in the same category as the rest of us. We are all here to make a few bob. Contrarian’s, shorters, LTH’s, investors, day traders. It matters not. Amongst all the rhetoric, ramping and deramping, I hope that if grounded people get a windfall they put a little aside to do a little good. Now that’s nice! and as for mr Contrarian I see through your hard arsed posts and I bet you like me have a list of people or causes that you are gonna help. And do you know what, that for me is actually the most exciting, fulfilling part of investing now helping others.
GBU.
Trek
TRek,
Ad you know, I am a contrarien so I prefer when the Sp goes down before news rather than up ....
Oops 394 should be 494, there fat fingers rule ok! Lol!
Trek
Ghia, I agree. NYT 2 days ago ran an opinion piece below supporting earlier interventios. SNG not mentioned by name but we know that we’re in this frame.
hTTps://www.nytimes.com/2020/05/22/opinion/coronavirus-treatment-mild-symptoms.html
Dragon project involving AI tech to catch early genetic / risk groups also with SNG. We are very much included in forward planning it seems to me. DYOR
2 very recent articles below Re: genetics and AI
hTTps://coronavirusexplained.ukri.org/en/article/cad0009/?utm_source=Twitter&utm_medium=social&utm_campaign=SocialSignIn&utm_content=%23CoronavirusExplained
hTTps://www.wired.com/story/covid-19-will-accelerate-ai-health-care-revolution/
Another interesting piece.
https://blogs.sciencemag.org/pipeline/archives/2020/05/21/there-may-be-a-unique-coronavirus-immune-response
Goose - What you are alluding too is also why I find our involvement in project DRAGON so intriguing.
“ DRAGON will apply artificial intelligence and machine learning to deliver a decision support system for improved and more rapid diagnosis and prognosis.”
I think we very much are being viewed as drug that could be used by many as a preventative.
Enjoy the wine and the weather!
Ps sorry for the sun/ wine induced typos
It would amazing to thinking that you could be monitored from home and your doses of medication be adjusted accordingly ! That would also go some way to collecting essential data in real time ! Thus accelerating the collection and updating of results . Not only for CóVID, but astman and CoPD
I like your thinking Goose everything seems to be pointing in that direction too.
Ghia ...... Just been reading some very interesting articles contained on this website, regarding CoPD and Asthma also also a linkein member Simon Bourne whos company have created an app for online monitoring of patients of CoPD, asthma, and other ailments. They also have online tutorials to use inhalers (who knows even nebulizer) how good would this be for the early medication of SNG and would tie in with early prevention needing hospitalisation.....
https://erj.ersjournals.com/ ........https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fmymhealth%2Ecom&urlhash=OI_1
The real beneficial results of SNG001 I believe will be when rapid POCT's are available and the treatment is administered early. Seem to remember in the recent article about how this virus manipulates our bodies own immune system stating that the interferon response naturally occurs within the first 7-10 days. After that the cytokine response is triggered more so if necessary. Clearly this virus is not killing people within 7-10 days of infection so this is the golden window of opportunity to boost vulnerable peoples immune systems. In general the elderly and people who have underlying conditions have less interferons to start with so virus replication will be faster and more damaging in this category. By the time this process has been going on for around two weeks they can be in real trouble and the second immune response, releasing cytokines adds to the inflammation causation and kills oxygen exchanging cells causing hypoxia which leads to organs coming under attack. So long story short any drug which can severely boost Interferon production in our bodies within the initial 7-10 day period must be of massive benefit. I dont see how that can be any other way tbh. I would strongly assume that patients enrollled on SG016 so far have been cherry picked, for lack of a better word to reflect the above timeframes involved. By getting early diagnosis and treatment into care home patients should show greater benefits imho. Lets hope so anyway!!.
Courtesy of the ADVFN board. Infection rate is starting to pose a problem in search for vaccinne.
https://www.theguardian.com/society/2020/may/24/uk-scientists-want-to-infect-volunteers-with-covid-19-in-race-to-find-vaccine
Fine tuning the immune system, getting in early and having to reduce the interferon later .... sounds familiar ....
Must be the mother in law, nagging again !
gkb47 - 2000 cases per day but not 2000 hospitalisationS per day. Moving to the at home delivery of the trial is in tune with the current situation.
I think most trials are still only authorised to recruit in the hospital setting.
Great posts Ghia,
According to the eu trial register, the 75% of the participants are aged 65 and over, so it would be fair to assume that home trials could also refer to care homes too.
https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001023-14/GB/
Jackman, Nojjer - Agreed. As the number of Covid cases drop the importance of getting the hospital trial set up and recruiting early is really coming to the fore.
We are likely to be the one of if not the first placebo controlled phase 2 trial to present a data set.
Unless a significant second wave heads our way it will become more difficult to fill these trials, look at the COPD trial that has spanned several virus seasons.
The hospital trial only needs to show a small effect and this will act as a launchpad to pushing this drug into the next stage. Turning a process that normally takes years into a matter of months all thanks to a bit of luck and quick thinking by the company.
The at home trials are likely to be a slower burner in the background but the data could be very favourable.
Ghia - to me there was an interesting observation from the Leicester consultant on the interview with Radio Leicester when he said that use of some of the existing trial treatments would show ‘small but welcome benefit’ to hospital cases. And he had actually referenced the SNG treatment without using the company name within the interview.
And that’s where I’m hoping this is all leading. Even a small benefit to hospitalised cases will be a positive - and IF there is further data from the home trial (where we suspect that SNG can deliver optimal benefit) that proves positive then that is a game changer for any further wave or outbreak ahead of any vaccine. Effective home treatment brings a whole new dynamic as a defence and that’s obviously the target for SNG and will also underpin its headline additional therapy for COPD and asthma.
Yes, it’s been a longer play for the SNG team but they’re doing it professionally and diligently rather than sellers of snake oil!!!
Thanks for your time to reply Ghia, much appreciated.
From what I can see, the science behind Sng is long standing and impressive, and I believe these trials are being conducted with the sort of integrity and savvy that should render them productive and reliable. And hopefully bring a marketable outcome for Sng.
Irrespective of this, the COPD aspect to this remains in the background, which may still prove to be a more certain, enduring market for this product over time. No one knows where the world will be with Covid in 6 months’ time.
If nothing else, it has propelled Synairgen forward in its efforts to get their product out there.
Nojjer - if you are looking for feedback on the science the real expert exists on the ADVFN board there is some really good debate happening there around all of these articles that keep cropping up.
One point on the suggestion that ‘at home’ is an afterthought or a reaction to perceived progress of the hospital trial.
I simply do not see this as the case.
The Hospital trial is a must, to ensure that data collected is robust and stands up to scrutiny. The amount of data such as bio markers, sputum samples etc collected during the hospital trial will far exceed the data collected during the at home trial.
But from the outset the company new getting to patients early was the key that’s why they set strict entry requirements on the hospital trial hence it’s taking longer to fill than other trials out there.
The at home trial is logistically complex and would not have been given the go ahead without some form of proof on safety of the drug in Covid patients. Add to that the complications with ramping up testing for people outside of the hospital/lab setting it’s clear that when we announced the initial trial the at home route was not viable.
I look forward to the results in June when some of these questions can be put to bed with the accurate data the company is collecting.
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30176-6/fulltext
Furstly I should acknowledge this was posted on the Advfn site with thanks to them, but I’m not sure if it has appeared here.
From my understanding of this, which may be incorrect, this would seem to offer an explanation why the home trials route has been inserted into the Sng research. The article seems to indicate that, given early as early as possible in the development of the illness, a product like sng would have a positive effect, but later in the illness, conversely it could have a detrimental effect.
There are undoubtedly more knowledgeable people here, better placed to assess that article than I am, so would be grateful for their thoughts and opinions.