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No problem with a couple of liveners after the jab - or even a settler, depending on how it takes you. Pity the poor Sputnik injectees though. Advised to abstain for 2 weeks before the first jab and 42 days afterwards. Think anyone did ?
btw Prof my dad had GBS 20 years ago when in his early 60s. Completely paralysed for a month - communicating with blinks - terrinble pain as well as the virus strips the nerve endings bare. Eventually after a whole body transfusion the crisis passed and he began a slow recovery. at the rehab centre in Haslemere. Since then he's had problems with his extremities and is a liability around glasses and china - but apart from that right as rain. His golf even improved as his feet were effectively just rigid anchors. it's a complicated bloody thing about which even the specialists know very little - but most people do recover well.
Using interferon ß-1 for trial purposes and research would not be deemed as an infringement, until and if it was marketed for supply. How else are developments going to take place and progress, this goes for any product pharmaceutical or otherwise. Synairgen and their patent attorneys will be well aware of this and will no doubt take appropriate action if required.
Chipping in here. Extavia was discussed weeks back, from memeory these are the drawbacks - it has to be diluted in 2ml water so lots of faffing and rsisk (guaranteeing sterility and exact dosage in non-professional setting, good luck). Also combining it with vitamins and other drugs in a treatment - how do you know which one was the one that worked, all?, one?, some?, which combo, etc etc... If this thread is about which product is better, SNG001 is far more straight forward to me. Just my opinion. NOt had time to read all thread so apologies if already stated. GLA.
@joey/Splodge - That's the only slight concern in my mind - that some pig-headed French politician like Macron looks to push through treatment of a French drug that is behind in its' development, has less extensive clinical trial data and questions over it regarding a patent (as per conversation we've seen all morning), and all for political one-upmanship.
It's clear that SNG001 is well ahead in terms of development. Let's hope that shortcuts aren't taken for political gain.
But I'm confident Home trial results coming soon and Activ-2 shortly after.
Giovanni - I speak fluent French. This is part of what spooked me yesterday. He is very clear that it's French teams that are working on this. Two trials - one headed by Cassanova - the other is the Coverage trial. For people at risk of developing severe complications.
Excellent debate on here this morning chaps. I was worrying about Extavia last night after seeing the French Dr’s tweet. I’m wondering how it slipped us by? Even Scinv’s contributions are useful as they have challenged others to pull back the facts we need. I think this is good news as it’s another trial that will add weight to our product but RM should be rightly raising this as a patent infringement.
In the Olivier Veran live interview yesterday, he said the interferon treatment was for people in a serious condition hospitalised. This implies it is SNG001 that he is talking about. My french is basic but their must be a fluent french speaker here that can perfectly translate what he said in the first 50 seconds.
For what its worth now I mentioned yesterday that the French Lady Scientist involved in nebulized beta 1b at the beginning of the Pandemic whose name I could not remember was Florence Ader, an infectious disease specialist in the Infectious and Tropical Diseases Department of Croix-Rousse Hospital in Lyon, and now involved in this Discovery trial with Extavia
The trial is open label and the comparitor drug is a vitamin supplement. Efficacy Phase: To estimate the effectiveness of experimental ambulatory treatments, compared to vitamin supplementation, in reducing the risk of hospitalization, oxygen therapy indication or death in ambulatory individuals with COVID-19 with aggravating risk factors.
So will France give an EUA for Extavia Interferon Beta for home patient use on the basis of 205 people dosed in an open label trial that doesnt have a placebo control?
If they do then its a good bet that SNG001 in USA would get an EUA from activ-2.
ps, the good news is there is no mention on the " package leaflet " that alcohol is prohibited / should not be taken, nor is there any mention that you should remain hydrated., so it's down to individuals to decide, ( hic )
Doc - Extavia is P3. French ministers said results in a few weeks. My head is bursting all this information. Is it good? Is it Bad. ...She's my sister, no she's my daughter...she's my sister and my daughter!!
Reassured by all of that folks - thanks. We won't know about the patent thing until it's tested i guess. And it'll be within the protection of a major pharma before too long. As many have said if it was a choice between the two - which it won't be - you know which one most health services would choose. Last question I have is whether we know what stage Extavia is at ? P2 or 3 ?
Oldapache. Love your post name. One of my girlfriends is a native Indian American called Miar. Stunning lady. I personally do not drink wine however I understand that the vaccine shouldn't be taken with alcohol.
@JoeyDiamand - like your manner of debate. Informative & educational. I do agree the patent leave the definition open for interpretation. However, there are bits which according to me point to influenza caused by influenza viruses. The first paragraph ends with one of the symptoms being ‘confirmed influenza infection’. That to me points to ‘influenza viruses’.
Secondly if you read further on you’ll find this paragraph. Here it is a bit more specific.
Quote from patent doc: ‘Background of the invention  Seasonal influenza is a common infection, especially during winter. Every year strains of influenza (type A or B) circulate ...’
Overall we’re good as our various approved & pending patents cover us well.
Yes Oil across many EU countries vaccine rollout is going to be slow so a plan B is needed. France are looking to Interferon and mAbs as that plan B.
Yes SNG will not be able to supply enough drug in short timescales. Demand outweighs supply. In that case alernative versions even if inferior will be required to help people from dying.
My personal take is even if SNG did have a 100% water tight patent and can be legally enforced (unknown), in the midst of a pandemic will SNG try and block the use of another Interferon Beta drug? Maybe a deal can be made with France? Commit to X amount of SNG001 pre orders over a period of 6 months and SNG will not challenge another interferon drug? All theoretical :)