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Thank you for answering my question Mr B.
Very much appreciated and understood.
Enjoy the rest of your Sunday.
Onwards and upwards.
Love it.....................!
regular calibration of the instrument, as well as repetitive hardware maintenance..........!
All the best (sounds good to me :()
GB
Yes of course I had assumed the cartridges, with there coating, would have a finite life and also that they would need replacing after any positive detection. That goes without saying and also, my use of 'fit and forget', was more to the point of no need to remember or schedule in a testing, no need for manual intervention and recording etc...
I should have made that clearer though, cheers.
Scenario....................!
I'm sat on the toilet, in Leicester, x3 weeks ago........... :) ermm.... taking a dump
All the best (now........... when would Priti know about it............? :()
"I am a member of the International Society of Aptamers" I bet you're fighting the flange off with a 5hity stick once you've told them that.
@AJS75
The b) section of your post. Aptamers are living organisms so have a definitive life, just like the bacteria reagents in MWG in their existing Microtox units. So RAWTest cartridges have to be replaced either when the virus is detected, or after a period of time (still to be determined, which is why we are working on them in our labs over the next 2 months).
@AJS75, @Trufflehound.
Integumen can use any source or means to capture the virus on the Cartridge plate. It could be Aptamers, it could be Affimers, it could be high frequency dielectrophoresis. The key issue is that we capture the virus onto the plate. So there are many sources. It is just convenient that we entered into an agreement a partner company called Aptamer Diagnostics. It just so happens that I am a member of the International Society of Aptamers. http://aptamersociety.org/
We are working with multiple development associates around the world and Aptamer Group are quite advanced. But they are not the sole knowledge on Aptamers.
@Gazala. The short answer is that we will have a slice of the equipment sales. However, the volumes of consumables and AI subscription is where recurring revenues are secured over years. Think of it like the installation of a Satellite dish, or mobile phone, or ink-jet cartridges.
Many thanks GB and AJS once again for your replies which have severely distracted me from the roast I'm supposed to be cooking.
Whilst I won't pretend to know exactly how it all works from your explanation as I am getting old, I do get the gist that Rinodrive AI remains at the heart of the wastewater solution, the reagents are still critical to said solution and that the Aptamers are an opportune enhancement rather than a replacement for anything.
Once again , many thanks to all .................. and finally , can rinodrive AI detect when a roast potato is perfectly cooked?
Thanks again GB, makes things clearer for me at least.
"As Director, CEO and shareholder of Cellulac this £400,000 loan facility was provided to Integumen to draw down as they see fit for whatever purpose they need. (Lender)"
copy that mate..............!
All the best (the others understood :)
@Chesh, working from my phone, so will check that out later and will have it corrected. Thank you in advance. Indeed the warrants were at 2p
@Chryslis
a) The reagents are used to identify any pathogen is the drinking or in fluent water from any source. They detect if the water is contaminated from up to 2,700 different types of contaminant. They do not identify what the pathogen is.
b) Aptamers are used to capture a specific target, such as a single or in the case of the area in each cartridge multiple pathogens. The problem is that you have to detect something that is 1/7000th thickness of a human hair. That is why the current process is the use of rtPCR back in a lab where to do so you need to convert the RNA to DNA and compare that to the known DNA code of SARS-CoV-2.
Using the RAWTest AI method we use a laser detection device to measure the captured molecule (pathogenic virus) take a digital image of this molecule and compare it to a dataset of samples, using AI to determine it is precisely the target pathogen. This takes as long as the Dataset runs its comparison. In the case of the bacteria we announced back in late 2019,it is under 4 seconds.
Aptamers capturing the target pathogen do not trigger any alert, it is the RAWTest and AI determination that does that.
Hope that is clearer.
Chrysalis1
Re you last post, this is my take to a) and b)
a) In reference to the RNS of the 18th March and 30th March, neither explicitly said they were supplying reagents to MWG to detect SARS-COV-2. Rather, that it was now in a revenue sharing agreement with them, to produce and supply reagents they already used and/or were compatible with their own monitoring tech. It is more recently I think that SKIN and MWG have been looking to develop an add-on piece of kit for use at Wastewater Plants to also now detect SARS-COV-2. Initially, Labskin will have been looking to develop an adequate reagent to make the spike protein of the virus bind to the photonic plates. I believe the optical change on the plate, upon binding would then trigger the 'Real Time' alert that would also feed back into a Wastewater Plants own IT monitoring infrastructure for recording and actionable purposes. Therefore the original reagent agreement with MWG has not changed it terms of its agreement, prospective volume and sales value per batch.
b) I am not sure what you are trying to get at here tbh (and this is not in any way being disingenuous), the RAWtest kit as previously noted will provide an automated 'fit and forget' option to detect SARS-COV-2 and a further 3 other targets (with the 4 unit set-up). There are many ways in which the SARS-COV-2 can be detected, SKIN are looking to provide a fully integrated piece of kit for the aforementioned reasons and will, via MWG, have sounded out the interest for this 'Real Time' AI tech. There will be in time other virus and bacteria detection updates I am sure, we already know about E Coli for one.
I hope this might help, but once again, maybe I have it wrong. Happy to be corrected.
-----------------------------------------------------------------------------------------------------------------
trufflehound
I kind of understand where you are coming from, but the Aptamer collaboration is just a part of the overall 'Real Time' package offering that is the ultimate offering end point. I am sure GB has done a thorough assessment of how this will be beneficial to SKIN, this 'Real Time' AI offering, with it's integratable abilities to existing on-site IT infrastructure etc...
Anyhow, maybe GB will give a better answer AGAIN to those concerns, but still quite happy with how things seem to be going and with the many strands SKIN has.
ATB
@Chesh June 15th RNS https://www.londonstockexchange.com/news-article/SKIN/unsecured-loan-facility-agreement-with-cellulac/14576914
As Director, CEO and shareholder of Cellulac this £400,000 loan facility was provided to Integumen to draw down as they see fit for whatever purpose they need. (Lender)
Chesh, you really need to sort your grammer out,
much as I like you, it has to be said!
You've obvs read this bit..............!
"Integumen will provide the Aptamer Group with access to its UK Sand Hutton manufacturing facilities, which specialises in laboratory grown human skin equivalents specifically designed to host bacteria, virus and fungi."
All the best (they are not lyrics BTW ............ :()
oh..........................!
your serious...................... ha ha :)
All the best (Material Transfer Agreement ("MTA") :)
Undertaken without charge,
just for you chesh!
Of course I do truffle...............!
"with or without you"................. :()
All the best (your lagging my friend :)
you do know what Pro Bono means don`t you chesh?
https://www.youtube.com/watch?v=ujNeHIo7oTE
just for you truffle................ :)
All the best (pro................? :()
Pro Bono Chesh, Pro Bono!
infact truffle..............!
sounds more like an ad at the end, a call to arms if you like............ :)
All the best (please get your test, so we can take x2 weeks to process it :()
Important........................................!
truffle............. the samples are sent to "biobot" lab for testing...............!
All the best (tell me.......... how long does that take ............ :()