London South East prides itself on its community spirit, and in order to keep the chat section problem free, we ask all members to follow these simple rules. In these rules, we refer to ourselves as "we", "us", "our". The user of the website is referred to as "you" and "your".
By posting on our share chat boards you are agreeing to the following:
You will only have one login account. Registering with multiple accounts is not allowed. Any user found to have more than one account on this site will have all, and any future accounts suspended permanently.
Your email and password must only be used by you. If a post is made under your account, it will be considered that it was posted by yourself.
Your account nickname must not be the same, or contain, listed company names or board members' names.
While debating and discussion is fine, we will not tolerate; rudeness, swearing, insulting posts, personal attacks, or posts which are invasive of another's privacy.
You will not;
discuss illegal or criminal activities.
post any confidential or price sensitive information or that is not public knowledge.
post misleading or false statements regarding the share price and performance. Such posts are deemed as market abuse, and may be reported to the appropriate authorities.
post any private communication, or part thereof, from any other person, including from a member of the board of directors of a listed company. Such posts cannot be verified as true and could be deemed to be misleading.
post any personal details (e.g. email address or phone number).
post live price or level 2 updates.
publish content that is not your original work, or infringes the copyright or other rights of any third party.
post non-constructive, meaningless, one word (or short) non-sense posts.
post links to, or otherwise publish any content containing any form of advertising, promotion for goods and services, spam, or other unsolicited communication.
post any affiliate or referral links, or post anything asking for a referral.
post or otherwise publish any content unrelated to the board or the board's topic.
re-post premium share chat posts on regular share chat.
restrict or inhibit any other user from using the boards.
impersonate any person or entity, including any of our employees or representatives.
post or transmit any content that contains software viruses, files or code designed to interrupt, destroy or limit the functionality of this website or any computer software or equipment.
If you are going to post non-English, please also post an English translation of your post.
If you are going to post non-English, please also post an English translation of your post.
The IP address of all posts is recorded to aid in enforcing these conditions. As a user you agree to any information you have entered being stored in a database. You agree that we have the right to remove, edit, move or close any topic or board at any time should we see fit. You agree that we have the right to remove any post without notice. You agree that we have the right to suspend your account without notice.
Please note some users may not behave properly and may post content that is misleading, untrue or offensive.
It is not possible for us to fully monitor all content all of the time but where we have actually received notice of any content that is potentially misleading, untrue, offensive, unlawful, infringes third party rights or is potentially in breach of these terms and conditions, then we will review such content, decide whether to remove it from this website and act accordingly.
Premium and Verified Members
Premium Members are members that have a premium subscription with London South East and have access to Premium Chat. You can subscribe here.
London South East does not endorse such members, and posts should not be construed as advice and represent the opinions of the authors, not those of London South East Ltd, or its affiliates.
Good morning Stoney40. Interesting abstract from the patent application/granting :-
'Accordingly, in further aspects, the invention provides:
2.8 A method of treating a disease or condition in a subject in need thereof, wherein the disease is selected from an inflammatory disease or condition, an immunological disease or condition, an allergic disease or disorder, a transplant rejection and Graft-versus host disease, or a disease or condition selected from sepsis and septic shock, wherein the disease or condition is susceptible to TYK2 inhibition, which method comprises administering to the subject an effective TYK2 inhibiting amount of a compound of the formula (0), (1) or (2) or a salt thereof as defined in any one of Embodiments 1.0 to 1.105. 2.9 A compound of the formula (0), (1) or (2), or a salt thereof, as defined in any one of Embodiments 1.0 to 1.105 for use in the treatment of an inflammatory disease or condition, an immunological disease or condition, an allergic disease or disorder, a transplant rejection and Graft-versus host disease; or for use in the treatment of sepsis or septic shock, wherein the disease or condition is susceptible to TYK2 inhibition. 2.10 The use of a compound of the formula (0), (1) or (2), or a salt thereof, as defined in any one of Embodiments 1.0 to 1.105 for the manufacture of a medicament for the treatment of an inflammatory disease or condition, an immunological disease or condition, an allergic disease or disorder, a transplant rejection and Graft-versus host disease; or for use in the treatment of sepsis or septic shock, wherein the disease or condition is susceptible to TYK2 inhibition.'
As Thoth correctly pointed out over 50% of illnesses and diseases are due to our immuno systems.
Yes it does seem ridiculous, however, put in the context of NYCT last year which peaked at over £12 in covid. They had supplied consumables for the crisis. In comparison, we have a potential therapeutic that can be used to treat the immune over reaction and take the strain off ICUs and bring the world economy back on track. Seriously, how much is that worth.......????
On top of this, it may also treat many other bacterial conditions from other virus attacks causing pneumonia.
The signs are already positive from the board, with Parker’s ‘major development’ tweet, the news from the half year results ‘encouraging results’ and ‘continued success’. Then as SOG says, we still have all the original autoimmune and cancer treatments that our TYK2s were designed for.
Bang on Sad, as working mentioned we will have the biggest herd we've ever seen arrive here- as we have seen in AIM the pump will propell the price way over 50p possibly into £ territory.
A lot of millionnaires will be made some twice or thrice over and Sareum will be a billion £ company as Thoth has shown and RMM in the past the figures are truly amazing but very very real.
And the best part- Sareum are not a covid play we have as you mentioned 1802 cancer no tox, no mtd, studied by the US army, worldwide patented, almost ph1 ready and no competition in the Tyk2 cancer space. 1801 going into ph1 auto-immune and chk1 can go ph3, anogenital orphan fast-track and other combo therapies as some inc. Cancer research shown. And of course on standby Aurora which is still good and has not failed.
I have taken the biggest confidence from the two scientists. These guys are nerds and not into ramping as we have seen. They are now as ahfam said using language that sayscwink wink, but till it goes into humans then we are still waiting.
I am very confident on covid19 and the fact patent and further indications, gives confidence.
Yes Thoth, the mind truly boggles. 2 billion dollars a year Remsdisivir just in the USA, for a drug that has the dreaded NDA black box warnings ie adverse toxicity and adverse side effects associated with it and only now allowed for use in emergency situations.
A good post from you Ahfam, top notch.
My thoughts, way of thinking or whatever you chose to call it leads me to add the following:-
If. and when 1801 gets it chance to be trialled and if found successful in any way shape or form for Covid alone would turn Sareum into a billion pound company overnight at least. If we take it also to be used in many other applications and also future flu pandemics ( (this will not be the last) after this one, plus its potential in all other immunotherapies then it indeed truly will be mind boggling. Of course there is also 1802 on top of that.
At the moment i see ( correct me if you have anything to the contrary) absolutely no competition from any other pharma or any other product which they manufacture has the potential of the Tyk 2 compound for the treatment of Covid. Toxicity and side affects being paramount problems as we well know.
Vaccines will work up to a point and there is not one which is 100% successful ( never will be), as we have seen some of the Covid 19 mutations are developing a resistance to them and hence have limited effect.. Always will be a case of playing to catch up. Over 7 billion people on the planet and under 160 million tested positive, Divide 160,000 by 7,000,000,000 and multiply by a hundred gives us just under 3% of known cases in the world population. sooner or later all 7 billion in whatever shape or form will be exposed to the virus along with the Covid mutations.
As I recall Tyk2 had no adverse affects at 30 times treatment dosage. The dosage was increased way beyond this to such an extent that the compound had to be reformulated to establish a maximum tolerated dose. This point I will stress again as one of the most important aspects of our compound. Tyk 2 1801 is not an answer all on its own, vaccines will need be required as will the wearing of masks for some time yet. If and when this pandemic finishes, Tyk2 will still be a strong compound for treatments for the purposes it was invented and tested for.
Call me want you want, but I am not ramping, just confident.
And im happy with 28p (am happy where the sp is now to be honest). But remdesivir as a covid therapeutic not really effective. Its notching profits of 2bn this year just in the USA just in hospitals. Pe ratio pharma is 85. Thats 160bn mcap. Add in non usa market. Non hospitals. Once daily pill. Not saying it will. Doubt it will. But **** me sideways if it does. Boggling