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Potnak - thanks for the reply - isn't this a great board with so many helpful contributors!!
There’s the relationship in the Patent!
https://imgur.com/a/Fhlw1Eo
SDC-1801 is from the group of Compounds for the earlier FLT3/4 and Aurora, then at a later stage tested the molecules against the JAK/Tyk2 kinases selectivity and from that data their SDC was shown too have good TYK2 profiles, the FLT3 and Aurora are related from them compounds too, so the doubt is if they couldn’t get the formulation right for MTD in FLT3 and Aurora and having trouble with SDC-1801 it dose look similar and a risk imo!
Hot, I'm not an expert, only what I learned here. Think RMM gave some insight in MTD and the alternatives we can go for. Tim described it as a good problem to have and they were struggling to make enough of the compound but that was over 18 months ago and they have changed the formulation. Have we made progress or not is my question. People here give Damion a hard time about MTD but it's a valid question that we all should be asking.
RMM and Fadec- I believe this is your field re. MTD.
Hi Potnak,
Thanks for clarifying that a level of MTD is required (I have so much to learn!).
So do we then get into the scenario where, let's say, we've pumped 3 litres of the drug into the patient in 24hrs and they have no obvious side effects but trials show anything over 100ml of the drug in 24hrs has no additional benefit? Therefore MTD hasn't been reached but we've identified maximum efficacy for a given timeframe?
Damion, were just waiting for you to publish the results chap. Come now what holding you back.
"Failing to reach MTD is not always a negative" it is a, requirement though. I know there are ways around this but we need an update. Its the sort if thing that will stop us getting a deal. I've always said that Sareum are above board with what they tell us and I still am but the Aurora thing has put doubt in my mind. They were telling us all was OK until we got the RNS saying it wasn't. I'm not being negative but I will listen to both sides of the story with £1000's at risk.
Damion - maybe they are waiting for news from elsewhere which they know will be due before 30th. If true, then they can't be holding back positive news because they don't yet have the news!
As for 'another failed attempt at MTD', is it feasible that the MTD is so high that they haven't yet reached it? After all, the definition is, "The most extensive exposure to a treatment that a patient may receive before he or she experiences unbearable side effects." If you drank 200 cups of tea in a day then the caffeine would probably kill you but who's going to drink 200 cups in a day? Failing to reach MTD is not always a negative.
No reason to hold back positive news, if its another failed attempt at MTD with the reformulation that will set everything back considerably, If they don't release the interim results by close of play next Friday then will trading will be suspended?
Well the 30th is a Friday EOM so I hope its not at 3:45 next friday because that probably means bad news ... but that Friday does seem most appropriate as its EOM
Hardly worth adjusting the pant line for 1.5m sales. Most of us long termers have the same or more number of shares than recently traded.
Love peace and harmony.
In the interim extension RNS they said they would confirm the date so we should get an RNS about an inbound RNS. Might be wishful thinking but i'm of the opinion that the interims will have something positive they want to comment on in the accompanying statement. Think Thoth said the same.
I don't know. Maybe the MM's are just trying to start a bit of action?
Why do you reckon potnak ? Pretty tough start this morning, God knows what's happening
Anyone for an 11 am RNS?
..regardless of whether buys or sales. It was more accurate in the days of quill pens. What a farce.