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Just my opinion but if there is a middle man then surely that would be the manufacturer. Its certainly not provexis.
Well, your previous post, calling Provexis the "middle men".
Even if Provexis expand demand vastly, it will always be more cost effective to use a specialist to make it, but that doesnt make it a "middle man" operation IMHO
Who's suggesting that Alf? Not sure where it's coming from.
That doesn't seem logical to me. Are you suggesting that Provexis should move from their business model of mainly being responsible for developing and maintaining IP and patents, to a specialist manufacturer of the product? How much would that cost, how would a factory be run when production is only required a few times per year?
Was only suggesting we would use a third party for the manufacture...ok so it might not be DSM, still sounds like man in the middle to me...
Just for info in case anyone is not aware.
DSM does not manufacture Fruitflow but instead has a company in Italy/France to do this work and they are called Indena SAS.
Not saying this is were Provexis will have it manufactured but they are already set up and we will not have to go through DSM to buy it.
Barbershop,
Without wanting to sound cheeky. Can I suggest you read the RNS again?
"Provexis will be responsible for the manufacture, supply and sale of its Fruitflow heart-health functional food ingredient to By-Health, and it will contribute scientific expertise necessary for successful commercialisation."
The Agreement between Provexis and By-Health is totally independent to the DSM alliance agreement and 100% of the profit on Fruitflow sold to By-Health will go directly to Provexis and nil to DSM.
https://otp.investis.com/clients/uk/provexis_plc/rns/regulatory-story.aspx?cid=1569&newsid=1523432
Almost sounds like we've set ourselves up to be man in the middle. DSM manufacture, we deliver to By health with a 10% markup.
Thanks Gixer you are a great help
everhopeful, its not an MOU but a long term strategic co-operation framework agreement and it lasts for 10 years, subject to extension and termination clauses.
They don't have the monopoly but do have the exclusive rights to act as the distributor of Fruitflow and sell Fruitflow based functional food and dietary supplement finished products in Mainland China, Hong Kong, Macau, Taiwan and Australia.
Provexis will be responsible for the manufacture, supply and sale of its Fruitflow heart-health functional food ingredient to By-Health.
What comes out of the negotiations with DSM is anyone's guess atm.
Re FF outgrowing PXS and -
We don’t want to be bought out, we want a hugely successful product and excellent profits.
It is the BODs job to get best value for shareholders but we are stuck with a MOU with Byhealth. This might not be a bad thing but there will be no competition as Byhealth has the monopoly . I haven't spent time I should have done looking into it all , I imagine and hope that DSM have a foot hold in the on going future production in China , if that is the case then there isn't as much wriggle room.
There seems to be a total disconnect between the academic field, where the link between sticky blood and Fruitflow as a therapy is discussed more and more, and the commercial field where we don't see any acceleration announcements . If this association is being brought to the attention of medics, it may spark the interest of many more companies than the usual suspects we know about IMHO. Given the "trading torpor" we have witnessed of late, surely something has to break ?
gixer
thanks for the info :-), looks like we are getting noticed !!
I can't help getting the feeling FF is outgrowing PXS....
WS
Came across that one this morning as well :)
Looks like it made reference to our own Med Hypotheses
"Platelet hyperactivity in COVID-19: can the tomato extract Fruitflow® be used as an antiplatelet regime?"
Hope this link works https://bit.ly/32Z3mxv
Google Scholar alert for Fruitflow flagged this paper today, published last week . All about platelets but unable to get free read of paper to see whether FF actually mentioned
https://www.tandfonline.com/doi/full/10.1080/09537104.2021.1961718
Coagulopathy is an evident complication of COVID-19 with predominance of a prothrombotic state. Platelet activation plays a key role. The terms “hyper-reactivity” and “hyperactivity” used in recent literature may not be clear or sufficient to explain the pathological events involved in COVID-related thrombosis (CRT). Inflammation may play a bigger role compared to thrombosis in COVID-related mortality because a smaller percentage of patients with COVID-19 die due to direct effects of thrombosis. Not all COVID-19 patients have thrombocytopenia and a few show thrombocytosis. We believe the platelet pathology is more complex than just activation or hyper-activation, particularly due to the platelets’ role in inflammation. Understanding the pathology and consequences of platelets’ role may help optimize management strategies and diminish CRT-associated morbidity and mortality. In this viewpoint report, we examine the published evidence of platelet hyper-reactivity in COVID-19 with a focused analysis of the key pathologies, diverse alterations, disease outcomes, and therapeutic targets. We believe that COVID-19 is a disease of inflammation and pathologic platelets, and based on the complexity and diverse pathologies, we propose the term “thrombocytopathy” as a more reflective term of the platelets’ involvement in COVID-19. In our opinion, thrombocytopathy is the unpredictable pathologic alterations of platelets in function, morphology and number, caused by different factors with a variety of presentations.
WS
I agree with you, but think that it won't be our choice. The big holders, and board, will have the choice.
We don’t want to be bought out, we want a hugely successful product and excellent profits.
gixer,
Many thanks for sharing the info. I like the following statement
statistically significant(P<0.001)
I was involved with some statistical modelling few years back.
statistically significant is something wonderful they achieved. It is matter of time BY Health is going to make an offer to buy us.
Our good friend IF should put all these links in PXS website.
Study on the Effect of Tomato Water-soluble Extract Xinluosu on Platelet Function and Its Molecular Mechanism.
Can't remember if this Chinese study has been posted before but also has quite a few references to PF4.
"The level of PF4 was also reduced after Fruitflow intervention,and the difference between before and after intervention was statistically significant(P<0.001)"
"Conclusions1.Fruitflow can inhibit platelet aggregation,reduce the production of TXB2,6-keto-PGF1aand the release of PF4 stimulated by ADP and Collagen."
"Fruitflow has certain application prospects and important scientific significance in the prevention of cardiovascular disease research."
https://dysw.cnki.net/kcms/detail/detail.aspx?filename=1021699508.nh&dbcode=CMFD&dbname=CMFDTEMP&v=
He did, yes.
Let's hope he includes the benefits of fruitflow on PF4 to cover this new discovery on why the vaccine causes blood clots.
gix/alf
thx.....
I recall the prof referring to an imminent paper on FF & CV during his recent AFC webinar. I don't think it's out there yet. ?
WS
This has been known for years. Keep up!
The problem has been/is that not enough people know about it.
Which may provide a novel evidence for the cardioprotective benefits of tomato.
WOW what a wonderful evidence. I take fruitflow daily and my blood pressure and heart rate are so normal. Now I know what is keeping all these normal.
gixer,
Many thanks for sharing your great find.
Conclusion: Fruitflow effectively inhibited platelet granule secretion via down-regulating platelet Src/PLC-?2/PKC signaling pathway in vitro , which may provide a novel evidence for the cardioprotective benefits of tomato.
It is definitely something good and waiting to explode. I will put some additional fund now before it explode in near future.
This other Chinese study also refers a lot to PF4
https://www.researchgate.net/publication/340194606_Fruitflow_attenuates_human_platelet_granule_secretion_through_down-regulating_SrcPLCg2PKC_signaling_pathway/fulltext/5e7ce5fd458515efa0ad6b2e/Fruitflow-attenuates-human-platelet-granule-secretion-through-down-regulating-Src-PLCg2-PKC-signaling-pathway.pdf
"Fruitflow inhibited platelet surface expression of CD62P, CD40L, and CD63. Moreover, agonist-induced release of platelet factor 4 (PF4)"
Can only be a good thing.