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AstraZeneca has started to move away from providing its Covid-19 vaccine to countries on a not-for-profit basis. The drugs giant has signed a series of for-profit agreements for next year, and expects to make a modest income from the vaccine, it said. 12 Nov 2021
I interpret the links provided as saying (1) They haven't in fact got as far as us. I understand that tomorrow's results will include some 'hard' info that has already informed Govt pandemic policy. (2) Our study is/was riskier since theirs is /will be on folk who have previous exposure (infection or vaccination), again AIUI.
Not sure how Oxford can do human challenge studies if Orph can’t? You’d have thought they might have come to Orph but they probably have better connections with government agencies and much deeper pockets, seeing as they made a fortune from the UK gov vaccine programme one assumes?
And this is the rationale for Oxford's study : .."'The aim of this trial is to find out what level of immune response - antibodies and T cells - we need in our bodies to prevent infection when healthy people are exposed to the virus. This is the immune response we then need to induce with a new vaccine. 'We have learned a lot about Covid over the past two years, but the emergence of new variants means that we will probably have to keep refining the vaccines. If we know what level of immune response we need the vaccine to induce it will make future vaccine development much quicker and much more efficient.'
Started April 2021..."and is currently establishing the lowest dose of Wuhan virus which, in approximately 50% of people who have previously been naturally infected or vaccinated, can take hold and start replicating but produce little or no symptoms. [ Ed.: This AIUI is the characterisation stage ]
"In the second phase of the study, all participants will be infected with the standardised dose of virus which was established in phase one. " [Ed.: This AIUI is the 'challenge' phase, which I THINK we've done, results not published]
The significant difference - again AIUI - is that 'ours' is / was more of an ethical 'challenge' as the future Oxford volunteers will already have antibodies either from previous infection or from vaccination (type(s) not disclosed), whereas our lot didn't (I think).
I understand we'll be given summary results of Imperial/HIC-VAC's version of this trial tomorrow.
This is all very nuanced . " I am a bear of very little brain , and long words bother me"
Confounded, I think you do Extrader an injustice. I’m sure you don’t intend to censor the board, but there is a tendency on here to try and quash any views that aren’t positive. That doesn’t make a healthy or objective board either. As you point out Extrader is a respected poster. I welcome his posts which are knowledgeable, courteous and measured. I am a LTH, very happy that we have had a good day and hoping for a good few more of them. ORPH is a great company but the SP has been a cause for concern. I hope that posters who raise valid and genuine questions don’t get shot down.
Extrader, I for one appreciate yours (or any other posters) legitimate or constructive ‘negative’ comments. If everyone adopted Confoundeds’ policy of not posting anything negative then I think the the general quality of the board would suffer. Not being critical of Confounded as that’s his personal choice and should be respected too. GLA
Think its clear todays rise was a combo of being at the bottom of the chart with things turning very nicely, along with Oxford covid19 recruitment for the challenge studies. Effectively gives the green light for us?
Ah desert thanks for thinking of me, I am very happy myself with the big gain today and hope it is not another false daw. I think I deserve credit as my constant calls for CF to sell OO has led to FOMO and this hopefully great beginning. Do not thank me all your welcome CF get this sold before April baby.
Perhaps you believe it all. Or perhaps you started as an investor and morphed into a very long term holder because someone has failed to meet his own deadlines, one of which, you might recall related to value accretion. To double every six months. And I'll buy that perfect second hand car from him too ( the engine is in the post). Come on! Ask Cathal.
Extrader, I am glad you are doing well, I just hope your posts across the BB recently did not encourage people with weaker conviction to sell based on a respected poster such as yourself sowing doubt, even if in your eyes you were trying to get to the bottom of things.
I find it amazing that experienced investors and newbies alike underestimate the impact of what negative posting on well followed public BB do. The share price can only ever be a reflection of investor (I.e BB) sentiment during period of quiet news. For ever poster on a BB there are 10’s of people that drop in on BB to gauge sentiment.
Since starting out on AIM (I am long only for my sins) I have very much stood by the rule that if I don't have anything positive to say I say nothing at all. Not because I want to be in an echo chamber, but because I know there are always plenty of posters who will self destruct their own holding by whinging or throwing up negative scenarios.
That said ORPH is pretty special for AIM and ultimately when the value is unlocked the share price will care little what has been discussed here over the recent months.
I'm not 'pushing negative sentiment', I'm an investor bemused by the continuing weakness in the share price over the last few months and disbelieving of the 'explanation' that it's all down to a disgruntled PI or II. People will be saying next that it's all down to those dastardly MMs...
I'm concerned enough to be trying to find out what - if anything - 'the market' knows that I don't. And CF's uncharacteristic 'radio silence' has - with respect - more effect on market sentiment than any PI's postings on a BB.
My interest should in itself tell you that, far from being 'on the wrong side' of a 15% move, I'm quite pleased at today's partial recovery. But I'd still like to know why the serious money hasn't moved in yet.
Elrico, Extrader has been on LSE and ADVFN posting the ship has sailed narrative for HVIVO on COVID CHIMs, pushing negative sentiment at a time we least needed it. It is quite possibly he has been caught out or with less than the full size of holding he wanted. He is a knowledgable and good poster but being the wrong side of a 15% move may be the crux of the gripe.
Extrader, what exactly is price sensitive about saying they are nit going to do a share buyback at the moment??? CF stated that in a previous interview and hasn't changed his tune. You seem to be looking hard at things not to like, relax if you hold things are looking better with the SP (whisper it but we may have seen the last of this seller), if you have recently sold then move on and invest wisely.