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VanV, thanks.
Its important that the nation gets the correct tests- irrespective if supply. This must be true for other countries. The FDA EUA may have been used as a proxy for quality. Now hopefully we can all get independent verification of the FDA EUA tests.
Our 100% homology with the 1743 full length good quality SARS-CoV-2 sequences published on the GISAID EpiCoV databas puts NCYT in a good place. You always said it was our Golden Goose. Let the Goose now fly......
gla
Good job chaps though - to be fair and in order to get answers more quickly will you be giving the government heads-up on this - would be more efficient - so they can provide responses tonight/tomorrow ??
Part 2
10. Please can the results of the epidemiological modelling, of the effects of recent social distancing measures, be presented?
A standard method of presentation is a graph of deaths per 10 million people per day, on logarithmic axis, plotted against days after the first death, on linear axis. It is appreciated that there will be uncertainties in the estimates, a problem that can be addressed by presenting upper, lower and central estimates. A graph of this type will also allow comparison with other countries.
11.The present format of the briefings does not allow the questioner to reply to the answers that have been given and point out where the answer given is deficient, at odds with known facts, or to suggest precisely the information that should be provided. There has been far too much shifty evasion and this needs to stop.
At the moment it is too much like PMQs where Government Ministers can simply not answer, willfully misrepresent and bluster. The briefings need a moderator of unimpeachable integrity - in previous days we could have had a Brian Walden, a Robin Day or a David Dimbleby - to keep order and make sure questions are answered properly and honestly, which at the moment they are not.
1/4/20
1.Three suppliers have been down selected to provide the UK with a covid 19 PCR test. Can the Government advise whom these suppliers are?
2. In March 2012 PHE evaluated various test systems to identify Covid 19.
See https://www.england.nhs.uk/coronavirus/wp-content/uploads/sites/52/2020/03/guidance-and-sop-covid-19-virus-testing-in-nhs-laboratories-v1.pdf
Can the results from the PHE assessment be declared by the Government?
3.Roche declared problems with their test (cobas SARS-CoV-2) at the time of their FDA EUA application. What percentage compliance to positive test cases does the Roche cobas SARS-CoV-2 test have?
Was this independently verified during the PHE assessment?
4.It is noted that in March 2020 Thermo Fisher took over Qiagen for $11.1B.
The PHE assessment reviewed the Qiagen QIAstat-Dx test but not the Thermo Fisher TaqPath test.
FDA EUA was granted to Thermo Fisher for the TaqPath test on 12/3/20.
FDA EUA was granted to Qiagenfor the QIAstat-Dx test on 30/3/20.
What test is the UK considering from Thermo Fisher?
What percentage conformance to positive test cases can the Government confirm for the Thermo Fisher test?
5.The Thermo Fisher test (TaqPath) was the first test to receive the FDA EUA approval (12/3/20). This application took 8 hours to approve. At time of the PHE assessment, why was this test not in the PHE evaluation?
6.The Qiagen (QIAstat-Dx) test had not received the FDA EUA approval at time of the PHE assessment. Why was this test considered in preference to the NCYT test for UK procurement?
7. The science behind the NCYT test is unassailable and compelling and that is why it remains at the top of the assay table.
The UK's Primerdesign (PCR) test provides an 'unmatched [diagnostic] tool' which has '100% homology' with Covid-19 and is one of the most accurate available. As of 27th March 2020 PrimerDesign can comfirm 100% homology with the 1743 full length good quality SARS-CoV-2 sequences published on the GISAID EpiCoV database.
Was the Government aware that the PrimerDesign test has a test time of 90-120 minutes?
9.For the provision of PPE and achieving 25,000 and 100,000 tests per day: Please can the public see the Gantt charts for achieving these objectives, so the following can be reviewed: the targeted end date; the dependencies; the critical path; and progress against the programme. This request is made necessary by the continued abject failure to deliver programmes to time. It simply will not do to pretend that the Gantt charts do not exist, since Gantt charts are the standard method of project planning.
Part 2 later