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Hemo truth ... Agreed i am not happy but I dont blame anyone else anymore. It was my decision to invest and my decision to listen to some. That's the risk on investing in these type of stocks.
it is no use getting angry on this board as most people are positive and heavily invested and under water in hemo here so why would we want to print more negative messages. We have no choice in being upbeat. Nevertheless, I agree on a few things here
- The company is not well run. It is a boutique project and has very few real big investors and so the share price hardly moves
- JHFH has tried immensely to create new investors but they don't seem to be out there at present. This is because people don't still believe things are imminent or have been approved. Again all HEMO have to do is actually get some news out there and this will rerate but delays after delays are stopping people blocking their money
- It is not use venting here as vlad doesnt listen to these pages. i know he has blocked you so there is nothing u can do except wait or sell. This is now the position I am sadly in
Overall my friend, we are all in a wait game. It is very slow and very demoralising but have no choice but to just hope that some bloody approvals come soon and something gets bloody announced.
People will sell whenever they want
This is a still a fearful and defensive market
Cash is King for many. Personal circumstances often demand sales! Maybe they even made a profit from the other week?
Who knows. I really don’t care. Good luck to all.
Pingu777 ... On a day like today when Vlad is expected to announce real updates, i cannot believe people are selling again
After speaking to JHFH in person and understanding more about the company and prospects, it just doesnt make sense that people would sell at this low price. The only thing I can decipher from this is these people are not expecting an RNS or any real news anytime soon. I don't think this is true but we have been waiting a long time for something that will rerate this stock and at present, every week goes by and this stays stagnant it is dead money.
I am still being patient but I am not sure it is delays or big expectations but we have all waited a long long time for something to change and yet it doesn't. Just don't know where the new buyers are gonna come from since they seem to investing in other stocks which make them money
Agreed Tillywhiz
It wont be a linear rise to 50p plus on developing a working drug or platform. But it has to start moving up at some point!
Hope investors keep the faith and can hold long enough to see HEMO blossom.
Agree it cant be £15m market cap for too much longer.
Evening all
Vlad on stage tomorrow good luck & see what occurs
Stock price won’t loiter at 1.5 forever , stock requires volume & tossed in the headlights to propel north .
# Clinical Trials
Good luck all , let’s hope all stockholders get a bonus for there patience.
Apologies if already posted but the intro to Vlads talk tomorrow at 9.35 was published in the conference prospective there are some heavy hitters presenting so it should be at least a good networking opportunity:
9:35 Anti-FLT3 CAR T and Bispecific Antibody Therapies for
Effective Elimination of AML and Conditioning for Hematopoietic
Stem Cell Transplantation
Vladislav M. Sandler, PhD, CEO & Co-Founder, Hemogenyx Pharmaceuticals
Relapsed/refractory acute myeloid leukemia (R/R-AML) has a poor prognosis
even with hematopoietic stem cell (HSC) transplantation. Surface expression
of FLT3 in leukemic cells and in HSCs provides an opportunity for targeted
therapy to eradicate FLT3+ R/R-AML and facilitate bone marrow conditioning.
We have developed chimeric antigen receptor modified T cells (CAR T)
targeting FLT3 and a humanized bispecific antibody (CDX) that recruits T cells
to eliminate FLT3-expressing cells.
Sorry, next year, at some point they need cash, higher mCap makes it easier, but I meant year
Diluted ????????
Well said Pingu :-)
Except I dont think its safe to remain at these levels for that long, I dont want to see my shares excessively diluted next week just because the SP is aloud to languish at these levels.
HT, I am a cheerleader for Hemogenyx because I believe the potential here is crazy and when you set it against the current mCap, insane. HOWEVER I have never said Vlad is perfect. I have had plenty of issues with him as CEO, some I have aired publicly in the past but most I have done in private directly to him as is appropriate. If he wont listen there are other board members and advisers as well. Attacking constantly the CEO and a company I believe in on a public bulletin board is neither constructive or likely to produce any results other than turning people away.
Anyway, Good luck tomorrow vlad!
#InVladWeTrust! :P
I think investors personal timelines heavily effect their views on HEMOs perceived success. Those accumulating stock at these prices and putting away for a few years will be the ones laughing.
Those wanting quick progress have been left frustrated sadly. But it is pharma after all. I dont imagine discovering cancer ending drugs is an easy process.
The current SP doesn't make it a bad investment even if you bought at 10p. That is, providing you are holding for 3-5 years. They'll be a bit anyed they have missed the cheap shares but not arguing on forums daily. Those who need their capital back in the short term are under pressure. That is not Vlad's fault.
I am WAY down from initial investments from way back when. However, I keep trying to accumulate more cheap ones as each month passes by. My son's JISA can wait as long as it takes for HEMO to succeed, he's only 4 haha
As Vlad said, its billions and years after all.
To be honest JHfH I couldn't give two hoots what you think, you are just a chearkeader for Vlad # invladwetrust who sees nothing wrong in Vlad.
In my opinion Vlad is out of his depth as a CEO , he has no business experience as he was just a university scientist ...all we are hoping for is that he is a good scientist and has discovered something of value.
All you have done JHFH. Is suck people into this share and made them lose money with your quotes of £1.80p a share and " thank me when you retire" .. well at 1.4p nobody is thanking you, certainly not Mr India !!
No need to reply as you will be wasting my time
@JustHereForHemo.
I cannot believe (actually, I can) that I forgot about that RNS
I did go over it a couple of times when it came out.
I better ask Mr. Sandler to develop a bait module, to capture the proteins or whatever, that causes people to get a bad memory:-)
Joke aside, the potential of it being effective against bacterial infections is seismic in my book.
Antibiotics can cause a bacteria to become resistant over time.
Some already are.
If this could solve that problem.
Vow
oh yeah I forgot to mention solvaldi was the name of the drug that gilead bought (RNA polymerase inhibitor) and it generated 19 billion dollars of revenue on a single indication.
What I particularly like about CBR is that it is potentially a platform to generate treaments targeted to specific viruses - This fits the model of big pharma although it is slightly disruptive because big pharma likes to inhibit a viral infection to manage the disease rather than cure (more profitable). Personally I was encouraged all those years ago when pharmasset was procured by Gilead for their HCV treatment as this was the first instance of big pharma being interested in a cure for hepatitis C. However, a broad spectrum antiviral was created by MIT's Dr Todd Ryder called double stranded RNA activated caspase oligomerizer (DRACO for short) this involved a protein that recognises very long double stranded RNA (which is unique to viruses as they hijack the cell to drive viral replication) binds and activates caspase (the enzyme that signals apoptosis) to kill any cell infected by a virus. This was tested in-vitro on multiple viruses and in-vivo (mice/flu) and worked yet no funding was recieved + no interest from big pharma- I can only imagine because it is broad spectrum and is a cure therefore didn't fit the pharma model of going after a single indications and managing the disease. Todd Ryder recently sold his patent to a start up company called Kimermed based in NewZealand and they are carrying on his work. The reason Hemo's offering in this space is different is that it isnt broad spectrum but a platform that would need to be tailored to each virus (unless viruses share binding proteins targets for cell entry) and therefore would (I imagine) appeal to big pharma.
HT, I get that your trying to take the pi... Urine out of me, but your right! It should be getting alot more press. And that is whats so frustrating, on paper Vlad has a cure for the common cold, and Aids, and measles, and god knows how many other conditions like MRSA and meningitis? It may not work against them all but if it can cure even a fraction then why are you not excited? Its straight from an RNS so either its real or Vlad has lied in an RNS, he has not lied...
Haywain your correct to point out cost being the deciding factor here, its potentially extremely expensive but we dont know yet, maybe we will know more this week about the future of CBR.....
Will it be purely a autologus therapy OR are they developing CBR to be used as off-the-shelf drugs....
It matters, its a very important distinction, the target market is vastly different depending on the answer, be good to have official confirmation one way or the other.
In theory if it works on corona viruses then that is exactly what he has done Hemotruth as the common cold is caused by corona/rhino viruses. But is is not some small molecule that could be delivered as a capsule or tablet to millions at first sign of a cold. It will be expensive to make and I presume therefore limited to serious viral/bacterial disease where a patient has run out of treatment options or that no treatment options exist.
So vlad has cured the common cold then??. You should tell the Daily Mail/ Express then JHFH..it will be be front page news
Socialist, just for more clarification, reading though the documentation and interviews etc to try and understand how its possible to have such a wide and crazy claim and it does seem to stack up. Whats not obvious is can vlad REALLY IP protect this whole set up.
So from my EXTREMELY basic understanding you can attack and destroy a virus/bacteria/cell by identifying it and attacking it, so say identifying the Spike protein on Covid-19 may release cytokines which attack, or antibodies may swarm and neutralise a cell or helper cells may bind to the foreign invading cell and bind it to say a B-Cell etc. Basically all these methods rely on identifying the foreign cell then using some form of attack. The cells that are easily identified and killed die off and mutations to say spike proteins that avoid detection go on to become dominant. Or cells that have a membrane that protect against some new antibody will survive and pass on that immunity. But they all need to be identified by the hosts immune system to be killed is the key factor.
What they all have in common is that they attack target cells by expressing proteins that bind to receptors on the healthy cells. Our human DNA based cells dont mutate, and whilst the invading pathogen might mutate it does not matter as any mutation that prevents it from binding to the CBR means it also cannot bind to healthy cells which is necessary to replicate.
The CBR probably attaches a receptor bait to I am going to guess macrophage but could be a number of cells, that will allow the pathogen to bind. I had a look at the proteins that can bind on Covid-19 and they are not a million miles away from measles or MRSA etc.
And even better, these cells can kill multiple pathogens, they swallow up the pathogen using the receptors to bind, they trap it in a vesicle but then the receptors return to the surface to go again, they dont die or disappear, REDUCE, REUSE, RECYCLE.
As a concept when you look for flaws, there are none, perhaps the cost of treatment, but when you consider when you go to the GP and you hear 2 things:
Its probably a virus there is nothing we can do for you just bed rest and fluids
and
We cant prescribe antibiotics, we are running out and they are not working any more.
Its hard to imagine that CBR wont start to prick some ears soon.
https://www.lse.co.uk/rns/HEMO/cbr-update-fywrltwvmef20hc.html
"§ CBRs are modular synthetic receptors that can be reconfigured to attack almost any virus, bacteria or mammalian cells, including cancerous cells."
I missed it too!
And Bo77ock7 what do you mean no evidence here? Its an RNS, For CDX and CAR-T the validation has been done by external parties they are working with, much of the CDX work validated by Eli Lilly, for CAR-t currently Penn and the FDA. For CBR Hemogenyx have said in a regulated RNS that they have tested it in the lab and it works in the lab and they are moving on to proving it in vivo. Do you want Vlad to post you his physical slides and printouts? If you cannot take his word which is in an regulated RNS as evidence then you really should not be here.....
@JustHereForHemo
I have missed the claim to ALMOST ANY bacteria/cells
I am aware of the almost any virus claim (which is downright impressive)
Can you please provide a link to where Mr. Sandler has mentioned CBR could potentially work on bacteria as well.
Many thanks in advance
JHFh ... i totally 100% agree with you but we have been hearing the same arguement now for over 1 year but no one is listening my friend. This does need a major shift in momentum and perception and this would only be driven by more new investors and large buys. I know there will be people trying to keep the price down but I always still get surprised by now and when we are expecting IND news (have been waiting for a long time), the people are not buying
Sorry mate, I am positive but now nearly end May and would have expected something nearer 2p by now ... been a long long wait
MrIndia, it is unhealthy to spend too much time watching, right now your seeing a red share price and feeling anxious when the reality is there is like 380k worth of sells and 1.16m buys (dhub i think the 240k is a buy personally). How many times have you seen the MMS move the price around to get people to buy or sell without actually changing the price? Try and focus on the bigger picture, when its tiny amounts like this its completely irrelevant.
PK, I dont think we expect this week to deliver the billions, I agree with you about any large investment decisions being unlikely, IMO any large investment decision by pharma will not be buying on main market anyway. But as seen this morning, the SP moves on < 1m shares. Vlad is not just speaking to the companies tomorrow morning, he is speaking to a room of potential investors many from the UK. I understand outside of that presentation he is also speaking to other investors again from the UK.
The argument I have frequently with people is that many of those with a negative standpoint here base that on a poor share price and a demand for additional news while refusing to look at what we already have vs the existing Share Price. Something that I HOPE and also believe experienced investors will do when they finally hear about Hemogenyx. When you take away the cash position we have a valuation of sub £10mil for Hemogenyx. That is in spite of the fact they have:
Hu-PHEC :Shelved but IP is owned and massive potential, still valuable
ApbHC : Not mentioned as much but with HvG benifits still valuable
CDX: "ready for IND-enabling studies, the final step before applying for a licence to conduct clinical trials." - CDX should attract significant interest from financial or strategic partners
CAR-T: now at an advanced stage of completing our application for IND status. expect to be in a position scientifically to commence trials once the IND designation has been granted.
CBR: modular synthetic receptors that can be rapidly reconfigured to attack almost any virus, bacteria, or malignant cells.
I get the negativity of some because of the share price, but do people get why you frustrate me when you focus on the SP?
Hemogenyx are sitting on CDX: A potential replacement for Chemotherapy NOT JUST for AML but for ALOT of conditions, Chemo makes treatment impossible for many patients.
CBR: Cure for some cancers and Covid-19 right now... BUT... ALMOST ANY Virus/Bacteria/cells???? We are talking about a whole new range of antibiotics here in a world terrified of MRSA becoming super resistant to the last remaining antibiotics!
If even a fraction of what Vlad is offering here comes to fruition this company WILL be worth billions. So please, give over about someone selling 5k worth of shares, they are idiots :P
Still dont understand why people are selling at 1.4p !!! This is so common every day and its getting silly. We need an RNS !!!!
Not to put a dampner on things, but I wouldnt expect the conference to boast the SP. DVS can explain the science and improve the awareness of HEMO CAR-T and CBR platforms in particular, which is great, but to expect investment decisions of any scale based on this is unlikely.
Notification of IND approval, and commencement of clinical trials will be the initial boast and then a continual rise expecting positive results... andif Phase I/2a results are positive (depending on what they go for)... in the words of Elton John... Rocketman!
As a recap:
Phase I: Examine the safety and dosage - typically 10-20 patients. Usually lasts up to 6 months.
Phase 2: Efficacy & side effects. This is a larger sample size up to 50 people and can be up to a couple of years. That said, given the nature of what we would be treating, they would combine 1 & 2. Plus life expectancies are likely to be shorter given AML so I would expect this to be substantially shorter than the 2 years.
Phase 3: This is comparing the treatment vs standard. Hundreds, probably thousands of patients and is multi-year. If we get to this stage then the business will be in the 100s million valuation as Phase 2 would have been successful.
Phase 3 successful... we will be in the billions as VDS says.
Well, at least the buys currently outway the sells 920k to 420k. We just have to wait MrIndia. There might not be any news until end of the week. Who knows???!!!
Patience is always required