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Bronx,
An excerpt from https://www.itv.com/news/2019-10-21/irish-scientists-announce-breakthrough-on-genetic-skin-disease/:
“We would not need to even take the patient cells for skin grafting. The gel would be applied, absorbed and go to work.
“We have seen some promising results in the lab. With further research, we could expand this to other EB types and even other genetic conditions.
“We are in the process of forming our own spin-out company to continue to develop this technology and take it to the next step, a clinical trial.”
Propinquity...how did you deduce that from the press release?
They're thinking of forming a spin-off company for further development and for trials - unless I've misread it.
It sounds to me like this therapy could be used for other skin conditions.. I'm wondering about Melanoma?
Diamondstar might know..
Here's hoping we get fast track approval..
That's my 10k earlier...I've too much tied up in BOI at the moment to buy more...(:
Irish scientists announce breakthrough on genetic skin disease
21/10/2019 - 06:36
By Press Association
Irish researchers have announced a breakthrough in the search for a cure for a painful skin disease.
Epidermolysis bullosa (EB) is a genetic condition in which sufferers lack a vital protein responsible for binding skin.
This results in painful blisters – both internal and external – from the slightest knock or bump.
The disease affects approximately 300 people in Ireland.
Researchers at University College Dublin (UCD) say they have now produced a solution that uses gene therapy to repair bad cells.
The best part of this therapy is that it would not involve painful skin grafting procedures or risks associated with viral treatments in delivering functioning genes to the skin
The breakthrough has the potential to provide a permanent cure for patients with Recessive Dystrophic EB, one of the most severe sub-types of the disease, for which no treatment currently exists.
The concept has been pioneered by Professor Wenxin Wang, who has been carrying out research into EB for the past 10 years, with assistance from the charity Debra Ireland.
Dr Jonathan O’Keeffe Ahern, one of the leading gene therapy researchers in Professor Wang’s team, said one of the greatest benefits of the solution is that it removes the need for painful surgery.
“The best part of this therapy is that it would not involve painful skin grafting procedures or risks associated with viral treatments in delivering functioning genes to the skin,” he said.
Gene therarpy researchers Dr Irene Lara-Saez and Dr Jonathan O’Keeffe Ahern (Shane O’Neill/PA)
“We call this the Fed Ex of gene editing – we deliver a biological solution using a simple carrier system.
“Rather like using a postcode, we can send in a genetic scissors to cut out the non-functioning part of a gene and then the repaired cells know to fill that space and permanently repair the gene.
“We would not need to even take the patient cells for skin grafting. The gel would be applied, absorbed and go to work.
“We have seen some promising results in the lab. With further research, we could expand this to other EB types and even other genetic conditions.
“We are in the process of forming our own spin-out company to continue to develop this technology and take it to the next step, a clinical trial.”
Debra Ireland head of research Dr Sinead Hickey (centre) with Dr Jonathan O’Keeffe Ahern and Dr Irene Lara-Saez, of the University College Dublin gene therapy research team (Shane O’Neill/PA)
Debra Ireland provides day-to-day help and support for EB patients and their families and also works to find better treatments and possible cures for EB.
This week (October 21-27) is National EB Awareness Week and the charity is asking the public to get involved by wearing a butterfly tattoo to raise awareness for this rare disease and funds for further .