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Be a contrarian investor says Ranjeet Singh


Sareum Share Chat (SAR)



Share Price: 0.875Bid: 0.85Ask: 0.90Change: 0.00 (0.00%)No Movement on Sareum
Spread: 0.05Spread as %: 5.88%Open: 0.875High: 0.875Low: 0.875Yesterday’s Close: 0.875


Share Discussion for Sareum


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iPedro
Posts: 212
Off Topic
Opinion:No Opinion
Price:1.20
RE: iPedro
19 Feb '17
Because they're nobs?
 
ahmir121
Posts: 1,396
Off Topic
Opinion:No Opinion
Price:1.20
RE: Autoimmune - TYK2 kinase!
19 Feb '17
Hope so .. perfect storm for sar ..good position cash payments coming in ...why not keep the momentum with a nice little update.
Fadec92
Posts: 2,999
Premium Chat Member
Off Topic
Opinion:No Opinion
Price:1.20
Autoimmune - TYK2 kinase!
19 Feb '17
Let's hope we get update on TYK2!

SRI and Sareum are working to complete the lead optimisation phase of discovery, prior to moving into formal preclinical development. In the course of this research we have discovered advanced lead molecules such as SAR-20347, which leads to a striking decrease in symptoms in preclinical disease standard models of psoriasis, rheumatoid arthritis and colitis.

Seeking to build on the insights gained from this research, we are synthesising new molecules with improved potency and other properties.

We intend to progress active compounds into other disease models including inflammatory bowel disease, lupus and multiple sclerosis.
ahmir121
Posts: 1,396
Off Topic
Opinion:No Opinion
Price:1.20
RE: Tomorrow results
19 Feb '17
Lol don ..

My simplistic taking on tomorrow is I am expecting a little more than just results ...Wether it's a little paragraph of positive wording regarding the future ..or a breakdown of what's happened so far and what is expected etc almost like a rundown.

I think some people/institutions maybe just awaiting the results and rns before committing...so if that's the case we could see alot of volume tomorrow.

Best of luck everyone
Donson69
Posts: 47
Off Topic
Opinion:No Opinion
Price:1.20
RE: Tomorrow results
19 Feb '17
always have an rns brandy treat lol,but I do work nights so it's allowed ;-) good luck to all,good rns tom or if only 6 month update,I think good times are coming!!

Gla...don
Fadec92
Posts: 2,999
Premium Chat Member
Off Topic
Opinion:No Opinion
Price:1.20
RE: Is this a positive sign?
19 Feb '17
So AstraZeneca discontinued AZN1480!

CONCLUSIONS: Whether the DLTs were due to inhibition of JAK-1/2 or to off-target effects is unknown. The unusual DLTs and the lack of clinical activity led to discontinuation of development.
Fadec92
Posts: 2,999
Premium Chat Member
Off Topic
Opinion:No Opinion
Price:1.20
RE: Is this a positive sign?
19 Feb '17
The top one in the data sheet is Astra!

AZD1480: a phase I study of a novel JAK2 inhibitor in solid tumors.

Randomized controlled trial

Plimack ER, et al. Oncologist. 2013.
Show full citation
Abstract

BACKGROUND: AZD1480 is a novel agent that inhibits Janus-associated kinases 1 and 2 (JAK1 and JAK2). The primary objective of this phase I study was to investigate the safety and tolerability of AZD1480 when administered as monotherapy to patients with solid tumors.

METHODS: Thirty-eight patients with advanced malignancies were treated at doses of 10-70 mg once daily (QD) and 20-45 mg b.i.d.

RESULTS: Pharmacokinetic (PK) analysis revealed rapid absorption and elimination with minimal accumulation after repeated QD or b.i.d. dosing. Exposure increased in a dose-dependent manner from 10-50 mg. Maximum plasma concentration (Cmax) was attained ∼1 hour after dose, and t1/2 was ∼5 hours. Pharmacodynamic analysis of circulating granulocytes demonstrated maximum phosphorylated STAT3 (pSTAT3) inhibition 1-2 hours after dose, coincident with Cmax, and greater pSTAT3 inhibition at higher doses. The average pSTAT3 inhibition in granulocytes at the highest dose tested, 70 mg QD, was 56% (standard deviation: ±21%) at steady-state drug levels. Dose-limiting toxicities (DLTs) consisted of pleiotropic neurologic adverse events (AEs), including dizziness, anxiety, ataxia, memory loss, hallucinations, and behavior changes. These AEs were generally reversible with dose reduction or treatment cessation.

CONCLUSIONS: Whether the DLTs were due to inhibition of JAK-1/2 or to off-target effects is unknown. The unusual DLTs and the lack of clinical activity led to discontinuation of development.
ahmir121
Posts: 1,396
Off Topic
Opinion:No Opinion
Price:1.20
RE: Tomorrow results
19 Feb '17
Lol.... that's early donson
SHAT2
Posts: 1,003
Observation
Opinion:Strong Buy
Price:1.20
RE: Is this a positive sign?
19 Feb '17
AZN I mean sorry its an age thing may be SAR can give me some thing for my little gray cells. GLA
Donson69
Posts: 47
Off Topic
Opinion:No Opinion
Price:1.20
RE: Tomorrow results
19 Feb '17
With a shot of brandy lol ;-)

Gla....don




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