let me randomly select a piece of string, then precisely measure it :)
201 is a peptide and peptides are notoriously toxic. However the 201 peptide is naturally occurring in the human body and thus seem completely inert. Thus the only adverse reactions seen have redness in the areas of injection, as one might naturally expect. The company has repeatedly said that it is working in-line with pre-clinical findings, which happen to have been excellent.
What we don't is the degree of efficacy seen. Though as all other therapeutic options either surgically or chemically castrate the patient, cause bone disease and mental retardation. I think its safe to say there is benefit to the patient over alternatives.
401 is a reformulation of respiridone, which is a psychotic drug used in lovely places like broadmoor to pacify patients. There is over 25 years of clinical data on respiridone, which means its safety profile is very well known, The affects on a neuro typical individuals seem negligible, so you don't get chemically lobotomized or anything like that. which obviously comes to mind. You gain weight, which happens to be good for cancer patients.
The risk on the 401 trial is that they are treating very ill patients, which might make observation complicated. Though you could have said the same thing for 201.
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