Epistem Regulatory News (EHP)

Company               Epistem Plc

TIDM                     EHP.L (AIM)

Headline                Directors' Shareholdings

Released                        7^th October 2011

Epistem Holdings Plc ("Epistem" or the "Company")

Directors' Shareholdings

Epistem today provides an update regarding the Company's share investment plan, details of which were announced on 13 July 2009.

As a result of the subscription for Partnership Shares and the award of Matching Shares, the executive Directors each increased their beneficial interests in the Company by 291 ordinary shares of 1.5p each. These shares were acquired on 29 July 2011, 5 September 2011 and 21 September 2011 at prices of 385p, 378p and 375p respectively.

Following these transactions, the current beneficial interests of the executive Directors are set out below:

Matthew Walls                             8,668                                   (0.11%)

Dr Catherine Booth                  983,023                                  (12.39%)

Dr Jeffrey Moore                        15,348                                   (0.19%)          

John Rylands                            192,921                                   (2.43%)

For further details please contact:

Epistem Plc

Matthew Walls, CEO                                                               +44 161 606 7258

John Rylands, Finance Director                                                 +44 161 606 7244

Peel Hunt LLP

James Steel / Vijay Barathan                                                     +44 20 7418 8900