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Plethora Solutions Holdings PLC Share Price (PLE)



Share Price Information for Plethora Solutions Holdings PLC (PLE)


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Directors Deals for Plethora Solutions Holdings PLC (PLE)
Trade DateActionNotifierPriceCurrencyAmountHolding
28-Oct-15Notification of Holding
Trade Notifier Information for Plethora Solutions Holdings
James (Jim) Mellon held the position of Chairman at Plethora Solutions Holdings at the time of this trade.
 James (Jim) Mellon
00243758261
01-Apr-15Notification of Holding
Trade Notifier Information for Plethora Solutions Holdings
James (Jim) Mellon held the position of Chairman at Plethora Solutions Holdings at the time of this trade.
 James (Jim) Mellon
00246613861
29-Jan-15Notification of Holding
Trade Notifier Information for Plethora Solutions Holdings
James (Jim) Mellon held the position of Chairman at Plethora Solutions Holdings at the time of this trade.
 James (Jim) Mellon
00145974014
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Keithbfk
Posts: 92
Opinion:No Opinion
Price:0.00
RE: Up
Today 14:40
Continued steady rise in share price would make for a very happy Xmas. GLA. It's been a bumpy ride.
bignose58
Posts: 2,026
Opinion:No Opinion
Price:0.00
RE: Up
Today 09:30
Bothwell,

Maybe this is the turning point. With a major Chinese license now in play which is far larger than the Recordati one with a huge population size, maybe investors are starting to take notice and realise the significance. Its going to be a continued spread of information which should be exponential. I am sure those that get in now will not regret it.
Bothwell
Posts: 269
Opinion:No Opinion
Price:0.00
Up
Today 08:57
Nice 7% today.
Alquemie
Posts: 1,013
Opinion:No Opinion
Price:0.00
RE: US study delay
Mon 15:13
Might be more than three years, as I've assumed an almost immediate turnaround from the COA division, no Type C meeting request and minimal delay in pivotal study site set-up. Possibly safer to add another 6-12 months.

I've assumed a single pivotal study, although as a new indication, the FDA might require two studies. Back of envelope stats calculation gives a minimum of 250-300 subject (couples) recruitment, but could be greater depending on the robustness of the PEBEQ instrument. I'd also expect a Type B meeting before NDA submission, which might add on another three months, and I've made no allowance for further clinical input (combination justification, any additional extended dosing tox,or for bridging studies if change in manufacture).

As to the BOD report card, since they are incapable of making a credible estimate of the PDUFA date, negligence and incompetence are reasonable accusations, as is "misleading", whether by design or not.

Looking back through my diligence notes, since end 2014, the anticipated US PDUFA date/launch has been variously stated as Q1 2017, Q2 2018, Q1 2019, Q4 2019, the last from the October 2017 company presentation. Approval timelines do change, but it takes talent to be so consistently wrong.

I've been transparent in my timeline estimate- why not ask the BOD to share their own assumptions?
The.Italian
Posts: 530
Premium Chat Member
Opinion:No Opinion
Price:0.00
RE: Recordati
Mon 10:46
bignose thanks for that very helpful.i will do as you suggest.i prefer tailor made enquiry anyway so you can keep a copy.probably do it tomorrow as on grandson minding duty later today
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