Avacta announces CAR-T cell therapy research collaboration with major US cancer centre
· CAR-T cell therapy is a major new area of cancer therapy that has attracted $billions of investment in the past few years
· Affimer technology will potentially provide significant advantages over antibody fragment technology currently used in CAR-T cell modification
· Proof-of-concept study with major US cancer centre has the potential to open up highly valuable licensing and partnering opportunities
Avacta Group plc (AIM: AVCT), the developer of Affimer® biotherapeutics and research reagents, today announces a research collaboration with Memorial Sloan Kettering Cancer Center (MSK) to evaluate the use of Avacta's Affimer technology in novel CAR-T cell-based immunotherapy.
CAR-T immunotherapy is a form of cancer treatment in which the patient's own immune system T cells are modified to give them greater potency with which to attack cancer cells (see Notes). Treatments using these engineered immune cells have generated promising responses in patients with advanced cancers and CAR-T immunotherapy has become an intense area of research, clinical development and investment.
The simple structure and biophysical properties of Affimers potentially provide significant advantages over antibody fragment technology currently used in CAR-T cell modification and the collaboration announced today is intended to demonstrate a new class of CAR-T cell therapy that incorporate Affimer molecules.
The collaboration will be led by Renier J. Brentjens, MD, PhD, Director of Cellular Oncology at Memorial Sloan Kettering Cancer Center in New York.
As part of the collaboration Avacta will develop Affimer molecules that bind different regions of CD19, a surface protein specific to B-cells involved in lymphomas. Dr Brentjens' team will construct CAR-T cells incorporating these Affimer molecules and test their anti-tumour function in vitro and in in vivo animal efficacy models.
Under the terms of the agreement the ownership of the results generated directly as part of this collaboration will be shared between Avacta and MSK.
Alastair Smith, Avacta Group Chief Executive commented: "CAR-T cell therapy is an emerging and very exciting area of immuno-oncology which holds enormous clinical potential. We are delighted to be working with a world-leading team in the field to demonstrate the benefits that Affimer technology could bring to CAR-T therapy. The generation of positive data in these validated models of disease has the potential to open up highly valuable licensing and partnering opportunities for Avacta in this therapy area which has attracted so much attention in the past couple of years."
Datafeed and UK data supplied by NBTrader and Digital Look.
While London South East do their best to maintain the high quality of the information displayed on this site,
we cannot be held responsible for any loss due to incorrect information found here. All information is provided free of charge, 'as-is', and you use it at your own risk.
The contents of all 'Chat' messages should not be construed as advice and represent the opinions of the authors, not those of London South East Limited, or its affiliates.
London South East does not authorise or approve this content, and reserves the right to remove items at its discretion.