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I've not been here for a while. It seems very quiet on this chat. I see Mr India is still here despite claiming he was waiting to sell at 4p - at least twice. Both times 4p hit and he's still here.
I sold at 1.9p. Now buying back to go in my ISA.
I would guess you’d need volunteers that were out of options but healthy enough to give Car-T a chance to work. I guess….
Wish I had more cash to top-up further but tapped-out and looking forward to CAR-T Phase 1 starting soon. I did anticipate after Easter around second week of April (just a guess on my part), but no idea how long the set-up for this would take. Obviously safety is always the priority and also appreciate they only have 1 shot at this, so happy for HEMO to take their time and hopefully generate some positive results from the very first patient dosing.
Good luck dhub. 👍
I know, I feel your pain mate. I think much of the problem is too many muppets have sold 20-25% UNDER the placing price of 2p. Who the hell does that unless you are desperate. Our day will come though............... Eventually
Thanks for the update Haywain. Very useful
How on earth is this 1.61p. unbelievable
Thanks very much, that's helpful.
Hi Diggit, In some cases, a single dose of CAR-T cells can lead to long-term remission especially in blood cancers like certain types of leukemia and lymphoma where this treatment has shown promising results. However, not all patients achieve complete remission with one infusion and may require follow up infusions. In terms of time frame to be able to measure an effect I presume there is some allometric scaling to be completed from the animal studies but I wouldn't imagine the timescale would be dramatically different - as a reminder measurements were taken from the engrafted mice at 18 days post treatment where they observed a dramatic reduction of FLT3 positive cells. In addition these patients associated with the trial will be placed on long term monitoring to understand the duration of effect as well as any side effects of treatment.
Haywain,
A query for you based on your relevant expertise. If the CART treatment works in a patient…do you expect this to be something that is noticeable in a day? A week? A month? I’m not scientific so picturing these little CARTs floating around the bloodstream, but can’t quite picture how quick or slow things might develop. Eg is it if no noticeable reduction in cancer cells after a week does that mean it doesn’t work or are the CARTs still building their army internally type stuff. Would you expect it is one and done or multiple repeat treatments? Yes I know this is phrased very untechnically I’m not trying to pretend I have a clue.
Digittt
Pretty sure hemogenyx did NOT make an application.....best take that one up with Vlad !
Fingers crossed 🤞 for a nice surprise tomorrow 😊
Surprise yes no RNS
I’m still of the opinion we will get a RNS before the Results RNS at the end of this month. Will it be about this, who knows? Fingers crossed 🤞 for a nice surprise tomorrow 😊
We are now in the Spring 2024 window for the announcement of New York Biofense Commercialization Fund Grants.
Did HEMO make a short submission; was it then invited to make a full submission - we don't know? But HEMO does seem to fit the application parameters - with its innovative CBR technology?
2022 Award Winners - announced 11 April 2022
2023 Award Winners - announced 4 May 2023
https://www.governor.ny.gov/news/governor-hochul-launches-applications-third-round-new-yorks-40-million-biodefense
Https://www.proactiveinvestors.co.uk/companies/news/1044876/hemogenyx-pharmaceuticals-important-fund-raise-and-car-t-potential-makes-it-one-to-watch-1044876.html
per the Proactive report and UPenn's continued interest/involvement - "all along it has been data driven"
And remember that Hemo had developed a safety switch for SAFE-HEMO-CAR-T but in the end they determined (presumably in the work with UPenn) that due to other scientific advances it was not necessary to have the esafety switch for HEMO CAR-T.
Poolbeg ( POLB), have a productive which greatly reduces cytokine storms, it's their lead product, and is already used for another purpose, so is safe for use in humans.
. thank you Hul.
maybe I shouldn’t be invested because I’ve got to keep reading over.
‘’these results highlight a need to tailor therapy to limit cytokine effects on AML blasts to improve outcomes with AML-directed CAR T cell therapy’s’’
Back to the science:
CD123 CAR-T was previously reported as UPenn's gold standard; here's what happened
https://ashpublications.org/blood/article/142/Supplement%201/217/503095/Cytokine-Release-Syndrome-Results-in-Reduced-AML
Note - one of the authors is Noelle Frey - who will now be the Principal Investigator for HEMO CAR-T Phase I at UPenn.
So - HEMO CAR-T now on pole position for the race to AML solution?
Blue finish by a maggots eyelash in very thin trading
1.615
Have a superb weekend all invested & lets see what next week brings
Hemo are clinical with cash in the bank & CBR & CDX cooking .
Afternoon all invested
Stagnant in thin volume awaiting updates .
3.3 million
To note -
Stock on loan / shorts
4.2 million -
Dropped 600 k yesterday- short closed
Cost to borrow- 15
Irrespective of daily market shenanigans,
Hemos science cogs keep turning & the stock will re rate when clinical news flows imo .
At current levels investors nibble fingers & use dry powder .
Recent Rns & article on Hemo very positive for the future.
Yeah I wondered that after posting, but thought it would have been done earlier in the week. You could be right though, makes sense
Those two look like a bed and isa . The second was at a higher price . Bid and offer were unchanged after and shortly after 300k appeared on the bid at 1.58
If the placing price is 2p, I ask the question would these guys sell at 1.2p or even below 1p?.........................Probably...........Extraordinary. Sometimes it takes time, but the SP always returns back to the placing price, EVENTUALLY.
12-Apr-24 08:13:37 1.553 1,000,000 Sell* 1.55 1.648 15.53k
12-Apr-24 08:13:26 1.55 1,000,000 Sell* 1.55 1.648 15.50k
Mr problem with MrI is that he can't make his mind up at all. I've never come across someone so erratic. If I was a new poster, on some days I'd think he's clearly pumping the stock here and is heavily invested. The next day, after a 0.1% drop, he seems like someone who has opened a short and is desperate to spread FUD. You can't change your beliefs and convictions in a stock/company on a daily basis. Yes there may be fluctuations from time to time based on certain events, but the guy seems to change like the wind.
OJ
What the fk are you talking about SS? What is India calling exactly? We can all see the stock has a low mcap compared to peers - we dont need him bleating about HEMO and Vlad everyday. Are you now suggesting he has some really deep insight - shall we follow the moan?
Is funding not secured to embark on Ph 1 trials? if you dont believe that why remain invested - just to fkn moan day in day out? and what is this truth that is being supressed