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EXCLUSIVE: Ascent Resources Operational Update & Review latest


Scancell Holdings Share Chat (SCLP)



Share Price: 14.00Bid: 13.50Ask: 14.50Change: 0.00 (0.00%)No Movement on Scancell Hldgs
Spread: 1.00Spread as %: 7.41%Open: 14.25High: 14.25Low: 14.00Yesterday’s Close: 14.00


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inanaco
Posts: 27,266
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ONW
Sun 23:34
Moditope is way more complex as its a MHC-11 interaction, and the T cells are variables they are after all the generals of the immune response ...

but this presentation is even more complex as the cancer it self has to be forced to present .... again by our friend Interferon Gamma

If autophagy is triggered during normal cellular homeostasis
or to promote cell survival, the triggering of a CD4C helper
response would be unhelpful. In contrast, under nutrient depletion,
hypoxia or intracellular infections these cells may have a
vital role to play. The key may be""" interferons that induce class II
expression."""" Although immune cells constitutively express MHC
class II, other cells, including epithelial cells, mesenchymal cells
and endothelial cells, lack expression unless induced by interferons.
Thus, autophagy induced in the presence of interferons
would allow presentation of peptides on newly synthesized
MHC-II molecules. Infections or cellular damage that induce
an interferon response would stimulate a T cell response. If
interferons also activate PADIs then these T cells would recognize
citrullinated peptides.
 
inanaco
Posts: 27,266
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so
Sun 23:28
CD4 T cells can differentiate into multiple effector subsets, including ThCTL that mediate MHC-II restricted cytotoxicity.
Oldnotwise
Posts: 5,341
Observation
Opinion:Hold
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RE: ONW
Sun 23:28
BS thanks for the response.... my point was quite simply that I read that each TCR is specific to one MHC1 and to my simple mind given the requirement to "match" and fine tune TCRs to the antigen presenting molecules there will be a great deal of work in optimising (which seems to me to be mind bendingly complicated and precise) the TCR for specificity relative to each cancer (which I'd sadly described as "mapping") struck me as a great deal of work.
However, a successful outcome to this process seems to offer a great deal of fiscal benefit. My main point was my embryonicly naive appreciation of the effort involved.
So maybe I should leave this as an observation....
ATB
inanaco
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Boom
Sun 23:21
so u see big difference in how you have worded "corresponding to" .... when the APC presents to ...

can you show reasoning ie how did you come to this conclusion

""A CD4 T cell with surface receptors corresponding to those peptides then binds to the APC."""

only that sounds like the T cell is already "tuned" to Scancells modified epitopes with out ever seeing th
inanaco
Posts: 27,266
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RE: Inanaco
Sun 23:16
boom ... "the binding is the encoding" ... the activation involves a host of messaging

These cells are also known as CD4+ T cells because they express the CD4 glycoprotein on their surfaces. Helper T cells become activated when they are presented with peptide antigens by MHC class II molecules, which are expressed on the surface of antigen-presenting cells (APCs). Once activated, they divide rapidly and secrete small proteins called cytokines that regulate or assist in the active immune response. These cells can differentiate into one of several subtypes, including TH1, TH2, TH3, TH17, TH9, or TFH, which secrete different cytokines to facilitate different types of immune responses. Signalling from the APC directs T cells into particular subtypes.[4]

in our cast the sub type is a cytotoxic cd4
Bermudashorts
Posts: 9,756
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ONW
Sun 22:45
Sorry, not quite with you re. mapping.

AFAIK, MHC1 are molecules on cell surface which present the antigen to the immune system.
Oldnotwise
Posts: 5,341
Question
Opinion:Hold
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RE: Inanaco
Sun 22:28
Apols
MHC1
Doh
Oldnotwise
Posts: 5,341
Question
Opinion:Hold
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RE: Inanaco
Sun 22:23
BS Purely idle curiosity but I thought I'd read somewhere that TCRs are specific to one MCH1. Is that correct?
If that's the case I'm beginning to vaguely understand the enormity of the "mapping" required. If not, I'll keep quiet lol!
ATB
Bermudashorts
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Ivy
Sun 22:17
Agree 100%.
Ivyspivey
Posts: 8,208
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View Thread (2)
Evening
Sun 22:14
Great scientific discussion tonight but would just want to make point to I imagine quite a few invested here.
Don’t worry if you feel a lot of this is above your head as imo you don’t need to know this level of detail to be fully aware of the compelling science here and have total confidence in the scíentific evidence supportive of Immunobody and Moditope.




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