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No
So the fundraise created enough cash to fund only 3 patients, but they need a funds to test 15 more patients before it can become a success?
Am I reading that correctly?
That interview is a guide only. But working back from December the first patient could embark on treatment at the beginning of September (and hopefully much sooner than that)
Not quite made up Gold...
https://www.proactiveinvestors.co.uk/companies/news/1044876/hemogenyx-pharmaceuticals-important-raise-and-car-t-potential-makes-it-one-to-watch-1044876.html?viewSource=TwitterUK
''Hemogenyx will use the newly raised funds to take HEMO-CAR-T into the clinic to treat AML later this year.
The open-label study will test for any potential side effects from treating people with blood-borne diseases and assess how the therapy interacts with the body.
A secondary goal or 'endpoint' will be whether any of the critically ill AML patients chosen for the trial respond to the CAR-T infusion.
Under the strict guidelines laid down by the US Food & Drug Administration, patients will be dosed individually one month apart, recognising people are being administered with a potentially toxic cells.
Hemogenyx hopes to have the results from “two, or even three patients” in time for the American Society of Hematology conference in early December.
Success at this stage would be a 30% response rate, says Dr Vladislav Sandler, chief executive and co-founder of Hemogenyx.
Investigational work will be carried out by a team from the University of Pennsylvania, led by Professor Nolle Frey, who has headed a number of important CAR-T clinical trials.
The entre was provided by Professor Carl June, the ‘father’ of CAR-T, and his colleague, Dr Saar Gill, who was involved in the preclinical research on HEMO-CAR-T.
On the university’s involvement, Sandler said: “This isn’t a situation where we’ve paid [UPenn] to carry out the work. They don’t work like that. All along it been data driven.”
While no guarantee of success, it provides validation for the science behind the efforts of Hemogenyx.
So expensive is the process of creating individual CAR-T treatments, that cash raised in February may be enough to dose three patients.
Hemogenyx will look to further non-dilutive funding to assess a cohort of around 18 AML sufferers, which will take it to the phase II stage of the clinical evaluation.
This is key, as it is the point that big pharma has weighed into the sector with the deals mentioned above''
Thanks Mr india.
I have read the RNS from March. I just could not understood where some people are saying about 3 person are receiving the treatment.
Just made up stories.
Just use Google....why not look at JV investments and pharma licencing deals why you are diving around
I have never been through the delist scenario so you're right, I have no idea and figured as it was a topic of conversation it'd be fair to ask for the cliff notes. I can do my own research, it'll just take me a little longer, thanks stu for giving something to dive into here
Afternoon all
To note -
Stock on loan / shorts
4.75 million
4.2 million opened 2 weeks ago @ 1.6 - costing money to keep open & making nowt - unlucky
a 500k short was opened yesterday
Perhaps attached to some of the negativity on here , who knows who cares ,
Current stock price 1.61 - + blue -
Vol - 6.3 million - thin
Let’s all invested hope a decent RNS drops & gets this clinical party started .
The recent article posted about Hemo was certainly loaded with potential for investors .
Let’s see what next few weeks bring
Goldwater ... no one on this site knows anything on timelines or whats really happening in hemo. Haywain is our resident super scientist. I would suggest you either look through the old RNSs and videos or contact hemo directly since this place is just full of rampers and derampers with their own agendas ... especially Stu who has suddenly reappeared. Maybe he knows as he seems to know when placing and other things are coming !!!
Still waiting for the RNS about the clinical trials. Anyone got any ideas when it might be.
Wasn't much of an apology Stu - no matter I didnt want an apology because I really am uninterested in what you have to say was just curious whether it would be provided - Fair do's, you have marginally gone up in my estimation. If you are implying that I have some sort of relationship with Hemo other than an investor you are wrong . I do however have 22 years of experience working on biologic products and the regulators (FDA included) mostly in rare oncology indications so call it what you like - educated guess
HT,
Yes that’s one possible explanation, there are others!!
AIMO
Ps Shicky’s still waiting.
It's because Haywain is a scientist, and you Stu, are a low life.
Haywire,
I’m happy you reminded me.
Yes , at present my prediction on the FDA’s concerns( not mine !) on the issue raised, has not resulted in any significant impact to those therapies and as such, presently my opinion has proven incorrect.
Always happy to stand corrected .
How is it , ahead of time your repeated posting of maybe 3 patients being dosed , ( very specific) and now the company confirming the same are so precise?
Congratulations on being spot on !!
AIMO
Stu, Er no, I certainly didn't know there was going to be a placing, and I didn't have any inside knowledge either. However, I strongly SUSPECTED there might be one, but only about 4/5 days before it actually came. I also started to offload quite a few shares because of that strong hunch. I have since bought back quite a few too, but not as many as I once initially held.
Interesting reading though. Nothing suprises me nowadays, hopefully not here
Are you still offering a full public apology Stu for your previous rounds of scare mongering and that FDA didn't share your opinion regarding the risk/benefit assessment of autologous CAR-T therapy in terminally ill patients?
"Haywain,
How could the FDA hold Hemo’s solution when presently they have no definitive conclusion on this particular risk with Car-T ?
Don’t be so obtuse and patronizing to the many others here less informed!
Let’s see what the FDA March meeting concludes.
I presume you will offer the same as i , a full and public apology should you be wrong and new FDA requirements become apparent?
AIMO"
Shicky is simply asking for help, not making out in any way he/she has that knowledge. If you aren't able to help then just say that
I don't think shicky has a clue about investing judging by his profile , so his comment is really clueless in respect of this share.
HT,
I’ve previously answered you !… No.
I think Dhub mentioned he was . Maybe he can help you with whatever related question you have.
Probably you could give Shicky some more details with respect to his/her question as a knowledgeable LTH.
AIMO
Stu, you never did answer my question as to whether you were one of those who received the soundings of the recent placing?
Answer the question!!!
Shicky,
Check out C4X and their recent RNS’s should you want to learn more on the de-listing and private company theme.
I’m not suggesting Hemo’ will , although many here intimating within recent posts, the possibility and logic to do so.
Maybe ask one of those posters for more details.
AIMO
MR I'm cannot see a problem here"even you said North of 20 pence by December "Come back I December
Agreed but i just feel we should all have less expectations of a major rerate anytime soon or it would have happened already. The placing was a long time ago and still no major buys. Trust is low and market is bad
We need real news on trials, funding, licencing or something as this vacuum is normality for hemo and people are bored of it and leave to invest elsehwhere.
A lot of underloved medical stocks are having big rises.
I feel HEMO is next given it's raised a decent amount of cash and the significance of its research.
The future of medicine.