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DonkeyOatey - message noted, reply sent a few days back. Any joy?
I hope we're not tilting at windmills ...
Come on AVO. Time to put up or shut up.
I'm not a royalist, but I've always admired a certain you-know-who for her quiet dignity. She - and Britain - deserve better.
Sort out your funding and get the cancer treatment technology out there. Or liquidate, sell the patents, and let others complete the task sooner rather than later. We, the shareholders, may lose out. But at least those with this dreadful disease may reap the benefit.
They, and we, have waited too long. It's time to wrap this up.
Thank you for your informative reply. I knew we were not involved as we had not been rns'd but was fishing for an explanation. Thank you for your knowledgeable insight
Basil,
Electron beam therapy and proton beam therapy are distinct modalities used in radiation treatment. Proton beam therapy is particularly known for utilizing the Bragg Peak effect, which allows for maximum energy delivery at a controlled depth, minimizing damage to surrounding tissues. Just Google.
FLASH (Fast Linear Accelerator System for Hadrons) therapy is an innovative approach that delivers an ultra-high dose of radiation in a single pulse. This technique can be applied using both electrons and protons, and is designed to maximize the therapeutic effect while minimizing damage to healthy tissue. The LIGHT system developed by AVO is an example of technology that can deliver FLASH therapy.
A LINAC refers to a Linear Accelerator, which is used to accelerate particles along a straight path, as opposed to circular accelerators like cyclotrons or synchrotrons. LINACs are versatile and can be used to accelerate various types of particles, including electrons and protons. AVO's innovation lies in adapting LINAC technology for proton therapy, which offers several benefits. These include the ability to rapidly adjust beam energies without loss of intensity, which is crucial for targeting tumors at varying depths with precision. Moreover, linear accelerators for protons can be more cost-effective compared to traditional circular accelerators.
So, the CHUV plan is technically not comparable with what AVO has in the pipeline. But if AVO would be able to deliver, I'm sure the CHUV would think about to use this much better technology.
Lost chance.
CERN, CHUV AND THERYQ JOIN FORCES FOR A
WORLD FIRST IN CANCER RADIOTHERAPY
CERN, the Lausanne University Hospital (CHUV) in Switzerland,
and THERYQ (ALCEN Group, France) signed an agreement
for the world-first development of a revolutionary FLASH
radiotherapy device that will use very high energy electron
(VHEE) radiation to treat cancers resistant to conventional
treatments.
The device will include a compact linear accelerator based on
CERN technology, and will use very high-energy electron beams
of 100 to 200 MeV, allowing cancers up to a depth of 20 cm to
be treated using the FLASH technique. It has the potential to
decrease the overall cost of treatment, and its compactness will
allow it to be used in a hospital setting. It will be based at CHUV
and is expected to be operational within two years, with the first
clinical trials planned for 2025.
The moratorium on restructuring for A.D.A.M has now expired. We will see if the BoD did their job.
Er, what, Iwant? The directors will be all together at ADAM for a meeting?
Tomorrow, children, something will happen!
Tomorrow we will be ???!
What a delight, what a life
There will be in our office!
Very interesting what you said about shareholder activism, would you like to send me a Google email using my username and adding the current four digit year before the squiggly A symbol? It would be very good for some of us to see if we can get together the necessary 5% to call a meeting.
Hi guys been away on holiday and missed the conversation regarding machine and treatment room.
I can confirm from the presentation at Daresbury which I attended, they had a fully operational machine that they were constantly testing for different measurements and readings.
The treatment room does have the robotic chair in situ but the room itself was far from patient ready, to be honest thinking back it seemed lacking in preparation for the the installation. A comparison would be when you have started decorating the lounge with everything stripped back and the wife walks in with a new expensive light fitting and she says can you put that up to see what it looks like, loves it and won't let you take it down or if I put it up it ain't coming back down.
Sorry second quote is from 29 February 2024.
The date of that "last major investment of 80 million" RNS is also worth noting - 23 October 2023, some four and a half months ago.
Then on 9 Jan 2024 they posted:
"As part of the envisaged transaction (the "Financing Transaction"), inter alia, it is also expected that the Company would be required to restructure its financial liabilities with a view to providing a long-term financing solution for the Company to continue as a going concern. The Financing Transaction would also be subject to, amongst other things, approval by shareholders of the Company and consent from certain other stakeholders of the Company."
Then on 9 Jan 2024 they posted:
" Discussions with the Investor on the Proposed Financing Transaction have, since 1 February 2024, continued to make progress and the Investor has re-confirmed their continued commitment to the Proposed Financing Transaction. However there have been further delays encountered with the Proposed Financing Transaction and the initial tranche of funding has, as at the date of this announcement, not been received."
The real giveaway that this finance is nowhere near is: "The Financing Transaction would also be subject to, amongst other things, approval by shareholders of the Company and consent from certain other stakeholders of the Company."
This is basically a rehash of the recapitalisation and funding plan announced on 17 July 2023.
"The last major investment of 80 million"
Iwant, I suggest that you read the RNS a little more carefully.
The points to note are "non-binding" and "envisaged".
Hence they do not have an $80m loan, they merely hopeful of getting one.
"The Company has recently signed a non-binding term sheet with a third-party (the "Investor"). Under this envisaged transaction (the "Financing Transaction"), the Investor is expected to provide funding of up to c.$80 million which is intended to meet the Company's cashflow requirements through to the European certification of the LIGHT System."
There are certainly former employees of AVO and ADAM here who know exactly what is going on.
The last major investment of 80 million until the breakthrough is certainly not just for a few small cosmetic works. The last phase is always the most critical and always underestimated.
But that was no different with Medaustron, on the contrary.
I don't think there will be much news until the end of March, because that's when the question of ADAM's survival comes up. Perhaps the delay is even because of that.
In an RNS dated 18 Jan 2023 about future deliverables AVO said:
“Completion of building (for first patients in Daresbury) and approval for patient treatment in accordance with UHB guidance and requirements:
For patient use, the Daresbury site is required to comply with cancer treatment facilities, including planning and design. The Company and UHB have designed the building together in compliance with the relevant specifications. The Company requires the acceptance of the patient care space by UHB prior to use.”
The treatment room built so far is not yet adequate for UHB’s needs.
I'm a believer, then again I was a beleiver in Monitse and contactless payments and UKOG with the 'Gatwick Gusher' Not to mention NCYT and Avo.
I believe because I cannot see they will scupper the ship for a 'ha'porth of tar' The major shareholders know that sucess brings massive rewards, failure - NOTHING!
Well Basil,
There is no doubting your prowess with ChatGTP and your forensic break down of the narrative from the June 2022 video.
In looking at your many posts, you are clearly an authority above mine
So tell me, have you seen the 'light', are you a believer?
00:02:39.959
investigation plan and first patient
00:02:42.239
treatment in conjunction with University
00:02:44.160
Hospital Birmingham
00:02:46.200
we've installed a state-of-the-art
00:02:48.239
robotic patient positioner for aligning
00:02:50.760
patients in the upright position in the
00:02:52.620
treatment chair also a CT Imaging
00:02:55.500
subsystem an x-ray Imaging subsystem and
00:02:58.680
Computing software and Hardware to
00:03:00.840
ensure accurate placement Imaging and
00:03:03.420
image processing of patients
00:03:05.700
light runs on an advanced Suite of
00:03:08.280
medical software the clinical workflow
00:03:10.980
starts with patient admission intake
00:03:13.379
appointments and creating images for
00:03:15.420
treatment planning the treatment plan is
00:03:18.000
verified approved and delivered to the
00:03:20.040
patient typically over multiple sessions
00:03:22.640
using this software Physicians are
00:03:25.140
supported throughout every step of the
00:03:26.940
process ensuring that patients can be
00:03:29.340
safely and accurately treated using a
00:03:31.860
beam that's been fully optimized and
00:03:34.080
tailored to their needs
00:00:13.759
begins in the northwest of England at
00:00:16.500
the Desiree laboratory of the UK's
00:00:18.660
Science and Technology facilities
00:00:20.220
Council where we've set up our
00:00:22.140
manufacturing site for the assembly and
00:00:24.240
integration of our modular light system
00:00:28.019
a hall has been built to house the
00:00:30.359
accelerators which form the Beating
00:00:32.279
Heart of the light system
00:00:34.380
because avo's light system uses linear
00:00:36.840
acceleration there's a considerable
00:00:38.820
reduction in the shielding that's
00:00:40.379
required and no need for absorbers to
00:00:42.719
handle stray excess radiation found with
00:00:45.420
Legacy cyclotron systems
00:00:47.579
this is a major advantage of the system
00:00:49.559
making it far easier and more affordable
00:00:52.140
to install
00:00:54.059
everything starts at our proton source
00:00:56.460
using a system called Equus known for
00:00:59.340
its robustness stable operation and long
00:01:02.219
lifetime
00:01:03.660
from there the protons starts their
00:01:05.939
Journey along a gallery of accelerators
00:01:07.860
moving as a 200 Hertz pulsed beam
00:01:10.619
through the CERN developed RFQ and
00:01:13.439
various accelerating modules called
00:01:15.380
scdtls and ccls accelerating up to a
00:01:19.140
maximum of 230 Mev
00:01:21.979
avo's linear accelerator is now fully
00:01:25.020
constructed and operating at a maximum
00:01:27.360
power of 230 Mev The energy needed to
00:01:31.320
treat deep-seated tumors this makes the
00:01:34.439
light system the only proton linear
00:01:36.479
accelerator to have achieved this feat
00:01:39.900
the accelerator is driven by four iots
00:01:42.720
and 13 klystrons all supplying RF power
00:01:46.439
to the accelerators and is called kept
00:01:49.079
under vacuum and monitored by beam
00:01:51.180
Diagnostics
00:01:52.799
DC supplies in the system Drive magnets
00:01:55.500
which control the position of the beam
00:01:57.479
and a full control system keeps the
00:01:59.759
entire system working optimally the
00:02:02.520
accelerator is driven from a control
00:02:04.020
room where our specialist operators
00:02:06.119
accelerate and steer the proton beam
00:02:08.699
there are over 250 front-end Control
00:02:12.180
software instances newly developed to
00:02:14.940
accelerate steer and monitor the proton
00:02:17.580
beam it utilizes 20 Gigabytes per day of
00:02:20.940
data capture in beam optimization and
00:02:23.040
control and delivers a proton pulse at
00:02:25.440
your energy of choice every five
00:02:27.480
milliseconds
00:02:29.280
the patient treatment itself which is
00:02:31.620
the final goal takes place in the
00:02:33.840
treatment room at the end of the
00:02:35.160
accelerator
00:02:36.420
this has also been built at daresbury
00:02:38.280
where we'll
Video states that patient room is installed and state of art positioning chair installed with all relevant soft ware in place 2.38/3.46
Linear accelerator is fully constructedand operating at max power of 230 Mev 1.25/3.46
So close anfd yet so far!
The treatment room was not ready, Basil. Part of the additional funds was to pay for it to be brought up to UHB’s requirements.
Whether the machine has reached full speed (230MeV) is irrelevant.
Before it can be used to treat UK patients it needs to be approved by the MHRA.
Europe and the USA have their own approval bodies.
If any of these bodies had approved the LIGHT machine, it would have been RNS'd immediately. How far it is away from being approved is anybody's guess. The BOD have not even said that they have completed all their own testing, let alone submitted it for approval.
For a system that claims to be ready for patients, there is little, if anything, by way of evidence that the machine has undergone any testing, nor to support the 230MeV claim. Seems you build a world changing device then say nothing
The treatment room is at the end of the accelerators that have acheived 230MeV. Video gives the impression that treatment room has robotic chair installed ready for first patient treatment?
The room may be ready for first patient treatment, but unless I've missed something, the LIGHT machine is not.